Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Melissa L. Hubbert"'
Publikováno v:
Molecular Endocrinology. 21:1359-1369
Activation of the farnesoid X receptor (FXRalpha) affects genes controlling many pathways, including those involved in bile acid and glucose homeostasis. Here we report that a critical gene involved in cholesterol homeostasis, Insig-2, was induced wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ad0aab6cb1c2e46701dc98ecc25b4b
https://doi.org/10.1210/me.2007-0089
https://doi.org/10.1210/me.2007-0089
Publikováno v:
Trends in Biochemical Sciences. 31:572-580
The farnesoid X receptor (FXR) is a ligand-activated transcription factor and a member of the nuclear receptor superfamily. In the past six years, remarkable inroads have been made into determining the functional importance of FXR. This receptor has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aedeff1ee1bdcc86629404219c47a33
https://doi.org/10.1016/j.tibs.2006.08.002
https://doi.org/10.1016/j.tibs.2006.08.002
Autor:
Melissa L. Hubbert, Whitney V. Christian, Nazzareno Ballatori, Paul A. Dawson, Ann L. Craddock, Noa Zerangue, Jamie Haywood
Publikováno v:
Journal of Biological Chemistry. 280:6960-6968
Bile acids are transported across the ileal enterocyte brush border membrane by the well characterized apical sodium-dependent bile acid transporter (Asbt) Slc10a2; however, the carrier(s) responsible for transporting bile acids across the ileocyte b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60c0ee7753d9fed61b05b3c5e63667e2
https://doi.org/10.1074/jbc.m412752200
https://doi.org/10.1074/jbc.m412752200
The organic solute transporter (OST)(alpha)-OST(beta) is an unusual heteromeric carrier expressed in a variety of tissues including the small intestine, colon, liver, biliary tract, kidney, and adrenal gland. In polarized epithelial cells, OSTalpha-O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7678781502044c934f184d7b7656d07c
https://europepmc.org/articles/PMC2911127/
https://europepmc.org/articles/PMC2911127/
Autor:
Peter A. Edwards, Noa Zerangue, Hans Lee, Timothy F. Osborne, Melissa L. Hubbert, Katherine Woodford
Publikováno v:
The Journal of biological chemistry. 282(30)
Fxralpha is known to regulate a variety of metabolic processes, including bile acid, cholesterol, and carbohydrate metabolism. In this study, we show direct evidence that Fxralpha is a key player in maintaining sulfate homeostasis. We identified and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5585c4e59c9254ec934bb914b35c1709
https://pubmed.ncbi.nlm.nih.gov/17545158
https://pubmed.ncbi.nlm.nih.gov/17545158
Publikováno v:
The Journal of biological chemistry. 275(48)
Niemann-Pick type C disease is characterized by the accumulation of cholesterol and other lipids within the lysosomal compartment, a process that is often accompanied by a reduction in acid sphingomyelinase activity. These studies demonstrate that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097f91699d8af8da286a7cf41a49af39
https://pubmed.ncbi.nlm.nih.gov/10978332
https://pubmed.ncbi.nlm.nih.gov/10978332