Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Melissa L. Geddie"'
Autor:
Melissa L. Geddie, Dmitri B. Kirpotin, Neeraj Kohli, Tad Kornaga, Bjoern Boll, Maja Razlog, Daryl C. Drummond, Alexey A. Lugovskoy
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Antibody-directed nanotherapeutics (ADNs) represent a promising delivery platform for selective delivery of an encapsulated drug payload to the site of disease that improves the therapeutic index. Although both single-chain Fv (scFv) and Fab antibody
Externí odkaz:
https://doaj.org/article/9d2891dc79f643129c3b3b205c1860ca
Autor:
Neeraj, Kohli, Melissa L, Geddie
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1575
The discovery of antibodies that bind to targets with high affinity is now a routine exercise. However, it is still challenging to screen for candidates that, in addition to having excellent biological properties, also have optimal biophysical charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f426809af84f07687a9cdfaf1fcc60d
https://pubmed.ncbi.nlm.nih.gov/28255881
https://pubmed.ncbi.nlm.nih.gov/28255881
Autor:
Melissa L. Geddie, Ichiro Matsumura
Publikováno v:
Journal of molecular biology. 369(4)
Our objective is to produce a protein biosensor (or molecular switch) that is specifically activated in solution by a monoclonal antibody. Many effector-dependent enzymes have evolved in nature, but the introduction of a novel regulatory mechanism in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3461d0288afd333d7a1484a01e37bc10
https://pubmed.ncbi.nlm.nih.gov/17467736
https://pubmed.ncbi.nlm.nih.gov/17467736
Publikováno v:
The Journal of biological chemistry. 280(42)
The dominant paradigm of protein engineering is structure-based site-directed mutagenesis. This rational approach is generally more effective for the engineering of local properties, such as substrate specificity, than global ones such as allostery.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454c6315f9a39e383e11f8a5d84d06aa
https://pubmed.ncbi.nlm.nih.gov/16118206
https://pubmed.ncbi.nlm.nih.gov/16118206
Publikováno v:
Methods in enzymology. 388
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a86aa8186c571619fb72ab34ea72b2ea
https://pubmed.ncbi.nlm.nih.gov/15289067
https://pubmed.ncbi.nlm.nih.gov/15289067
Publisher Summary This chapter examines protocols for a versatile but relatively inexpensive high throughput microplate enzyme assay. Escherichia coli cells constitutively expressing a library of proteins are seeded into liquid media contained in 384
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d07d15e5ec0ddde21f13854daf38cc29
https://doi.org/10.1016/s0076-6879(04)88012-1
https://doi.org/10.1016/s0076-6879(04)88012-1
