Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Melissa L. Geddie"'
Autor:
Melissa L. Geddie, Dmitri B. Kirpotin, Neeraj Kohli, Tad Kornaga, Bjoern Boll, Maja Razlog, Daryl C. Drummond, Alexey A. Lugovskoy
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Antibody-directed nanotherapeutics (ADNs) represent a promising delivery platform for selective delivery of an encapsulated drug payload to the site of disease that improves the therapeutic index. Although both single-chain Fv (scFv) and Fab antibody
Externí odkaz:
https://doaj.org/article/9d2891dc79f643129c3b3b205c1860ca
Autor:
Neeraj, Kohli, Melissa L, Geddie
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1575
The discovery of antibodies that bind to targets with high affinity is now a routine exercise. However, it is still challenging to screen for candidates that, in addition to having excellent biological properties, also have optimal biophysical charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f426809af84f07687a9cdfaf1fcc60d
https://pubmed.ncbi.nlm.nih.gov/28255881
https://pubmed.ncbi.nlm.nih.gov/28255881
Autor:
Melissa L. Geddie, Ichiro Matsumura
Publikováno v:
Journal of molecular biology. 369(4)
Our objective is to produce a protein biosensor (or molecular switch) that is specifically activated in solution by a monoclonal antibody. Many effector-dependent enzymes have evolved in nature, but the introduction of a novel regulatory mechanism in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3461d0288afd333d7a1484a01e37bc10
https://pubmed.ncbi.nlm.nih.gov/17467736
https://pubmed.ncbi.nlm.nih.gov/17467736
Publikováno v:
The Journal of biological chemistry. 280(42)
The dominant paradigm of protein engineering is structure-based site-directed mutagenesis. This rational approach is generally more effective for the engineering of local properties, such as substrate specificity, than global ones such as allostery.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454c6315f9a39e383e11f8a5d84d06aa
https://pubmed.ncbi.nlm.nih.gov/16118206
https://pubmed.ncbi.nlm.nih.gov/16118206
Publikováno v:
Methods in enzymology. 388
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a86aa8186c571619fb72ab34ea72b2ea
https://pubmed.ncbi.nlm.nih.gov/15289067
https://pubmed.ncbi.nlm.nih.gov/15289067
Publisher Summary This chapter examines protocols for a versatile but relatively inexpensive high throughput microplate enzyme assay. Escherichia coli cells constitutively expressing a library of proteins are seeded into liquid media contained in 384
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d07d15e5ec0ddde21f13854daf38cc29
https://doi.org/10.1016/s0076-6879(04)88012-1
https://doi.org/10.1016/s0076-6879(04)88012-1
Publikováno v:
Biobetters; 2015, p203-220, 18p
Autor:
Geddie, Melissa L., Kirpotin, Dmitri B., Kohli, Neeraj, Kornaga, Tad, Boll, Bjoern, Razlog, Maja, Drummond, Daryl C., Lugovskoy, Alexey A.
Publikováno v:
mAbs; Jan-Dec2022, Vol. 14 Issue 1, p1-10, 10p
Autor:
Kamoun, Walid S., Kirpotin, Dmitri B., Huang, Zhaohua Richard, Tipparaju, Suresh K., Noble, Charles O., Hayes, Mark E., Luus, Lia, Koshkaryev, Alexander, Kim, Jaeyeon, Olivier, Ken, Kornaga, Tad, Oyama, Shinji, Askoxylakis, Vasileios, Pien, Christine, Kuesters, Geoffrey, Dumont, Nancy, Lugovskoy, Alexey A., Schihl, Sarah A., Wilton, John H., Geddie, Melissa L.
Publikováno v:
Nature Biomedical Engineering; Apr2019, Vol. 3 Issue 4, p264-280, 17p