Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Melissa L. Dowling"'
Autor:
Wafik S. El-Deiry, Gary D. Kao, David T. Dicker, John P. Plastaras, Melissa L. Dowling, Xiaobing Tian, Akiva Mintz, Jay F. Dorsey
Supplementary Figures 1-2 from Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) and paclitaxel have cooperative in vivo effects against glioblastoma multiforme cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e387668c94c07ba9dac8b72de80c49
https://doi.org/10.1158/1535-7163.22485029
https://doi.org/10.1158/1535-7163.22485029
Autor:
Wafik S. El-Deiry, Gary D. Kao, David T. Dicker, John P. Plastaras, Melissa L. Dowling, Xiaobing Tian, Akiva Mintz, Jay F. Dorsey
Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) in conjunction with microtubule-targeting agents may be a promising novel anticancer treatment strategy. In vitro studies have suggested that relatively low concentrations of TRAIL enh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1466e40e9505600bf8833d372d9930ff
https://doi.org/10.1158/1535-7163.c.6531731
https://doi.org/10.1158/1535-7163.c.6531731
Autor:
Sharon E. Parker, Mijin Kim, Shulin Wang, Gary D. Kao, Melissa L. Dowling, Jessica Liao, K. Ranh Voong, Wafik S. El-Deiry
Publikováno v:
Cancer Research. 68:3440-3449
Tumor necrosis factor–related apoptosis–inducing ligand (TRAIL) has attracted interest as an anticancer treatment, when used in conjunction with standard chemotherapy. We investigated the mechanistic basis for combining low-dose TRAIL with microt
Autor:
Fang Liu, Amit Maity, Nabendu Pore, Melissa L. Dowling, Gary D. Kao, K. Ranh Voong, Mijin Kim
Publikováno v:
Molecular Biology of the Cell. 17:585-597
Histone deacetylases mediate critical cellular functions but relatively little is known about mechanisms controlling their expression, including expression of HDAC4, a class II HDAC implicated in the modulation of cellular differentiation and viabili
Publikováno v:
Journal of Biological Chemistry. 279:34537-34546
Histone deacetylase 4 (HDAC4) is a class II HDAC implicated in controlling gene expression important for diverse cellular functions, but little is known about how its expression and stability are regulated. We report here that this deacetylase is unu
Autor:
Eric A. Lee, Michael K. Keutmann, Melissa L. Dowling, Eleanor Harris, Gordon Chan, Gary D. Kao
Publikováno v:
Molecular Cancer Therapeutics. 3:661-669
Drugs that disrupt microtubule dynamics include some of the most important of cancer chemotherapies. While these drugs, which include paclitaxel (Taxol), are known to invoke the mitotic checkpoint, the factors that determine cancer cell killing remai
Modulation of the anti-cancer efficacy of microtubule-targeting agents by cellular growth conditions
Publikováno v:
Cancer biologytherapy. 9(10)
Mitotic spindle-disrupting agents target and disrupt microtubule dynamics. These agents include clinically important chemotherapies, including taxanes (paclitaxel (Taxol), docetaxel (Taxotere)) and vinca alkaloids (vincristine (Oncovin), vinblastine)
Autor:
Xiaobing Tian, Wafik S. El-Deiry, John P. Plastaras, Melissa L. Dowling, Jay F. Dorsey, Akiva Mintz, David T. Dicker, Gary D. Kao
Publikováno v:
Molecular cancer therapeutics. 8(12)
Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) in conjunction with microtubule-targeting agents may be a promising novel anticancer treatment strategy. In vitro studies have suggested that relatively low concentrations of TRAIL enh
Autor:
M. Cecilia Crisanti, Kara Coleman, Steven M. Albelda, Fabian Vandermeers, Luana Pereira, Barbara G. Campling, Zvi G. Fridlender, Africa F. Wallace, Melissa L. Dowling, Gary D. Kao, Veena Kapoor
Lung cancer is the leading cause of cancer deaths in the United States. Current therapies are inadequate. Histone deacetylase inhibitors (HDACi) are a recently developed class of anticancer agents that cause increased acetylation of core histones and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257467012e652161c9ccb6c5da178a35
https://europepmc.org/articles/PMC3605895/
https://europepmc.org/articles/PMC3605895/
Autor:
Gary D. Kao, Sharon E. Parker, Melissa L. Dowling, Katie M. Murphy, Mijin Kim, Wesley Baff, Fang Liu
The fidelity of chromosomal duplication is monitored by cell cycle checkpoints operational during mitosis. One such cell cycle delay is invoked by microtubule-targeting agents such as nocodazole or paclitaxel (Taxol) and is mediated by mitotic checkp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbdbe9f84aa550f94f6e031daf436b19
https://europepmc.org/articles/PMC1265846/
https://europepmc.org/articles/PMC1265846/