Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Melissa L Chow"'
The mechanical environment modulates intracellular calcium oscillation activities of myofibroblasts.
Autor:
Charles Godbout, Lysianne Follonier Castella, Eric A Smith, Nilesh Talele, Melissa L Chow, Adriano Garonna, Boris Hinz
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64560 (2013)
Myofibroblast contraction is fundamental in the excessive tissue remodeling that is characteristic of fibrotic tissue contractures. Tissue remodeling during development of fibrosis leads to gradually increasing stiffness of the extracellular matrix.
Externí odkaz:
https://doaj.org/article/03c2ba9e5aa0423a9116f3fac6558e52
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36821 (2012)
Determining the molecular mechanisms that lead to the development of heart failure will help us gain better insight into the most costly health problem in the Western world. To understand the roles that the actin protein plays in the development of h
Externí odkaz:
https://doaj.org/article/8f342a7da295465da3f0ee814b7db858
Autor:
Monika Lodyga, Abby L. Olsen, Marielle Walraven, Rebecca G. Wells, Stellar Boo, Michelle Im, Grace Chau, Eric S. White, Boris Hinz, Anne Koehler, Franco Klingberg, Melissa L. Chow
Publikováno v:
Journal of Cell Science.
Dysregulated secretion and extracellular activation of TGF-β1 stimulates myofibroblasts to accumulate disordered and stiff extracellular matrix (ECM) leading to fibrosis. Fibronectin immobilizes latent TGF-β-binding protein-1 (LTBP-1) and thus stor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e264837decab54889d8415a7e865b6d
https://doi.org/10.1242/jcs.201293
https://doi.org/10.1242/jcs.201293
Autor:
Anne Koehler, Elena Zimina, Melissa L. Chow, Boris Hinz, Vincent Sarrazy, Hideyuki Kato, Christopher A. Caldarone, Chen Li
Publikováno v:
Cardiovascular Research. 102:407-417
Aims Pathological tissue remodelling by myofibroblast contraction is a hallmark of cardiac fibrosis. Myofibroblasts differentiate from cardiac fibroblasts under the action of transforming growth factor-β1 (TGF-β1), which is secreted into the extrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4aaca8f0c63c09ac05a2db1b5044e8
https://doi.org/10.1093/cvr/cvu053
https://doi.org/10.1093/cvr/cvu053
Publikováno v:
Chow, ML; Shaffer, JF; Harris, SP; & Dawson, JF. (2014). Altered interactions between cardiac myosin binding protein-c and α-cardiac actin variants associated with cardiomyopathies. Archives of Biochemistry and Biophysics, 550-551, 28-32. doi: 10.1016/j.abb.2014.04.003. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/25657002
The two genes most commonly associated with mutations linked to hypertrophic or dilated cardiomyopathies are β-myosin and cardiac myosin binding protein-C (cMyBP-C). Both of these proteins interact with cardiac actin (ACTC). Currently there are 16 A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e13b01ac1a6d4abe5b74dc7fabc330
http://www.escholarship.org/uc/item/25657002
http://www.escholarship.org/uc/item/25657002
Autor:
Boris Hinz, Mercedes Costell, Elisabeth Génot, Franco Klingberg, Thomas M. Quinn, Stellar Boo, Benjamin A. Alman, Anne Koehler, Melissa L. Chow, Lara Buscemi
Publikováno v:
Klingberg, Franco Chow, Melissa L. Koehler, Anne Boo, Stellar Buscemi, Lara Quinn, Thomas M. Costell Rosselló, Mercedes Alman, Benjamin A. Genot, Elisabeth Hinz, Boris 2014 Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation Journal of Cell Biology 207 2 283 297
The Journal of Cell Biology
Journal of Cell Biology, vol. 207, no. 2, pp. 283-297
RODERIC. Repositorio Institucional de la Universitat de Valéncia
instname
The Journal of Cell Biology
Journal of Cell Biology, vol. 207, no. 2, pp. 283-297
RODERIC. Repositorio Institucional de la Universitat de Valéncia
instname
A mild strain induced by matrix remodeling mechanically primes latent TGF-β1 for its subsequent activation and release in response to contractile forces.
Integrin-mediated force application induces a conformational change in latent TGF-β1 that
Integrin-mediated force application induces a conformational change in latent TGF-β1 that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbe96936a8fa8552a8ef499e9c8b363
http://hdl.handle.net/10550/54633
http://hdl.handle.net/10550/54633
Autor:
Adriano Garonna, Charles Godbout, Eric A. Smith, Lysianne Follonier Castella, Nilesh Talele, Melissa L. Chow, Boris Hinz
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64560 (2013)
PLoS ONE
PLoS ONE
Myofibroblast contraction is fundamental in the excessive tissue remodeling that is characteristic of fibrotic tissue contractures. Tissue remodeling during development of fibrosis leads to gradually increasing stiffness of the extracellular matrix.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ec2c0b5a5f4dd5e49c75fa1030ebdf
https://infoscience.epfl.ch/record/189101
https://infoscience.epfl.ch/record/189101