Towards stratified treatment of JIA: machine learning identifies subtypes in response to methotrexate from four UK cohortsResearch in context

Autor: Stephanie J.W. Shoop-Worrall, Saskia Lawson-Tovey, Lucy R. Wedderburn, Kimme L. Hyrich, Nophar Geifman, Aline Kimonyo, Alyssia McNeece, Andrew Dick, Andrew Morris, Annie Yarwood, Athimalaipet Ramanan, Bethany R. Jebson, Chris Wallace, Daniela Dastros-Pitei, Damian Tarasek, Elizabeth Ralph, Emil Carlsson, Emily Robinson, Emma Sumner, Fatema Merali, Fatjon Dekaj, Helen Neale, Hussein Al-Mossawi, Jacqui Roberts, Jenna F. Gritzfeld, Joanna Fairlie, John Bowes, John Ioannou, Melissa Kartawinata, Melissa Tordoff, Michael Barnes, Michael W. Beresford, Michael Stadler, Paul Martin, Rami Kallala, Sandra Ng, Samantha Smith, Sarah Clarke, Soumya Raychaudhuri, Stephen Eyre, Sumanta Mukherjee, Teresa Duerr, Thierry Sornasse, Vasiliki Alexiou, Victoria J. Burton, Wei-Yu Lin, Wendy Thomson, Zoe Wanstall

Publikováno v: EBioMedicine, Vol 100, Iss , Pp 104946- (2024)

Summary: Background: Methotrexate (MTX) is the gold-standard first-line disease-modifying anti-rheumatic drug for juvenile idiopathic arthritis (JIA), despite only being either effective or tolerated in half of children and young people (CYP). To fac

Externí odkaz: https://doaj.org/article/c923074c829f4905a534120f1e8c1050

Patient-reported wellbeing and clinical disease measures over time captured by multivariate trajectories of disease activity in individuals with juvenile idiopathic arthritis in the UK: a multicentre prospective longitudinal study

Autor: Joyce Davidson, Coziana Ciurtin, Wei-Yu Lin, Kimme L. Hyrich, Jenna F. Gritzfeld, Athimalaipet V Ramanan, Wendy Thomson, Elizabeth Ralph, Sally-Anne Dews, Aline Kimonyo, Fatjon Dekaj, Paul Martin, Emil Carlsson, Zoe Wanstall, Lucy R. Wedderburn, Saskia Lawson-Tovey, Annie Yarwood, Beth Jebson, Toby Kent, Stephanie J W Shoop-Worrall, Sandra Ng, Chris Wallace, Emily Robinson, Joanna Fairlie, Michael R. Barnes, Alice Chieng, Samantha L. Smith, Andrew D. Dick, Teresa Duerr, Damian Tarasek, Andrew D. Morris, Jessica Neisen, Melissa Kartawinata, Fatema Merali, Emma Sumner, Eileen Baildam, Helen Neale, Michael W. Beresford, Helen E. Foster, Soumya Raychaudhuri, Flora McErlane, Gavin Cleary, Gil Reynolds Diogo, Yiannis Ioannou, Nophar Geifman

Publikováno v: Shoop-Worrall, S, Hyrich, K, CLUSTER Consortium, Wedderburn, L R, Thomson, W & Geifman, N 2020, ' Patient-reported wellbeing and clinical disease measures over time captured by multivariate trajectories of disease activity in individuals with juvenile idiopathic arthritis in the UK: a multicentre prospective longitudinal study ', The Lancet Rheumatology, vol. 3, no. 2, pp. E111-E121 . https://doi.org/10.1016/S2665-9913(20)30269-1
The Lancet Rheumatology

Summary Background Juvenile idiopathic arthritis (JIA) is a heterogeneous disease, the signs and symptoms of which can be summarised with use of composite disease activity measures, including the clinical Juvenile Arthritis Disease Activity Score (cJ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28b2329d637410519e22c4b9cca6d8f
http://www.scopus.com/inward/record.url?scp=85097886139&partnerID=8YFLogxK

Single and multiple high-risk and low-risk Human Papillomavirus association with cervical lesions of 11,224 women in Jakarta

Autor: Farid Sastranagara, Lydia S. Murdiyarso, I Made Nasar, Iffat Jenie, Grace Widjajahakim, Ruth E Sembiring, Heriawaty Hidajat, Santoso Cornain, Melissa Kartawinata, Ahmad Utomo

Publikováno v: Cancer causescontrol : CCC. 27(11)

We sought to evaluate prevalence, age-adjusted distribution, and impact of single and multiple high- and low-risk human papillomavirus (HPV) subtypes and their associations with cervical lesions.Data were extracted from 11,224 women who underwent rou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f676e1090f75a40886e2cf0348f37843
https://pubmed.ncbi.nlm.nih.gov/27752850