Confirmation of Recurrent Lung Cancer Following Resection Using Liquid Biopsy, a Proof-of-Concept Real-World Study

Autor: Julia R. Naso, Stephen Yip, Curtis Hughesman, Barb Melosky, Tanner Dowhy, Melissa K. McConechy, John C. English, Penelope M. A. Brasher, James Choi, Kyle Grant, John Yee, Stephen Lam, Anna McGuire

Publikováno v: Current Oncology, Vol 31, Iss 7, Pp 4052-4062 (2024)

Appropriate management requires timely and accurate confirmation of non-small cell lung cancer (NSCLC) recurrence in patients who have had curative-intent surgical resection. We assessed the association between circulating tumor DNA (ctDNA) identifie

Externí odkaz: https://doaj.org/article/b18337e3aa12439f9926c642c63041ac

Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas

Autor: Ralph Salloum, Melissa K. McConechy, Leonie G. Mikael, Christine Fuller, Rachid Drissi, Mariko DeWire, Hamid Nikbakht, Nicolas De Jay, Xiaodan Yang, Daniel Boue, Lionel M. L. Chow, Jonathan L. Finlay, Tenzin Gayden, Jason Karamchandani, Trent R. Hummel, Randal Olshefski, Diana S. Osorio, Charles Stevenson, Claudia L. Kleinman, Jacek Majewski, Maryam Fouladi, Nada Jabado

Publikováno v: Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-12 (2017)

Abstract Pediatric high-grade gliomas (pHGGs) are aggressive neoplasms representing approximately 20% of brain tumors in children. Current therapies offer limited disease control, and patients have a poor prognosis. Empiric use of targeted therapy, e

Externí odkaz: https://doaj.org/article/833c658027c5472dad6ddac83cfab32a

Variability in endometrial carcinoma pathology practice: opportunities for improvement with molecular classification

Autor: Emily F. Thompson, Jutta Huvila, Amy Jamieson, Samuel Leung, Amy Lum, Saul Offman, Alice Lytwyn, Mona Lisa Sur, Lynn Hoang, Julie Irving, Nicholas van der Westhuizen, Chantale Morin, Cyrille Bicamumpaka, Nazilla Azordegan, François Gougeon, Kaoutar Ennour-Idrissi, Janine Senz, Melissa K. McConechy, Rosalia Aguirre-Hernandez, Victoria Lui, Carolyn Kuo, Cassidy Bell, Taylor Salisbury, James Lawson, Ellen He, Shanzhao Wang, Derek Chiu, Sarah Kean, Vanessa Samouëlian, Shannon Salvador, Walter Gotlieb, Limor Helpman, Stephanie Scott, Christoph Wohlmuth, Danielle Vicus, Marie Plante, Aline Talhouk, David Huntsman, Carlos Parra-Herran, Mary Kinloch, Katherine Grondin, C. Blake Gilks, Jessica N. McAlpine, Jessica McAlpine, Anita Agrawal, Omar Al-Nourhji, Alon Altman, Marcus Bernardini, C. Bicamumpaka, Mark Carey, Blaise Clarke, Nazila Azordegan, Bojana Djordjevic, Laurie Elit, Alex Ferenczy, Sarah Finlayson, Anthony Fyles, Hugo Garneau, France Gauthier, Prafull Ghatage, Blake Gilks, Kathy Han, Hal Hirte, Fleur Huang, Katharina Kieser, Mary Kinlloch, Iwa Kong, Aalok Kumar, Janice Kwon, Sandra Lee, Eric Leung, Helen Mackay, Eve-Lyne Marchand, Justin Mcginnis, Dianne Miller, Gregg Nelson, Manuela Pelmus, Annick Pina, Anna Plotkin, Diane Provencher, Anna Tinker, Alicia Tone, Stephen Welch, Nicholas Westhuizen, Katarzyna Jerzak

Publikováno v: Modern Pathology. 35:1974-1982

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21ba941ca766a49ef2842e5b6df53618
https://doi.org/10.1038/s41379-022-01165-w

Supplemental Appendix from Endometrial Carcinomas with POLE Exonuclease Domain Mutations Have a Favorable Prognosis

Autor: Jessica N. McAlpine, C. Blake Gilks, David G. Huntsman, Cheng-Han Lee, Linda J. Reha-Krantz, Janine Senz, Winnie Yang, Derek Chiu, Samuel Leung, Aline Talhouk, Melissa K. McConechy

Supplemental methods Supplemental Table S1: Clinical characteristics of all POLE mutated and POLE wild-type endometrial carcinomas Supplemental Table S2: Clinical characteristics of POLE mutated and POLE wild-type endometrial carcinomas with associat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a802423d6254aa5781784ea88d0ad18
https://doi.org/10.1158/1078-0432.22458762

Abstract 5590: Liquid biopsy testing in metastatic or advanced breast cancer patients during the COVID-19 pandemic

Autor: Benjamin L. Furman, Ebru Baran, Sonal Brahmbhatt, Betty Chan, Ka Mun Nip, Adrian Kense, Brenda Murphy, Vincent Funari, David G. Huntsman, Ruth Miller, Melissa K. McConechy

Publikováno v: Cancer Research. 83:5590-5590

Objective: During the COVID-19 pandemic, cancer patients had restricted access to standard of care tissue biopsy. Liquid biopsy assays using next generation sequencing technology provides a less invasive method for determining circulating tumour muta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e39e19fa7de40cf5090dc8c2f97dc78
https://doi.org/10.1158/1538-7445.am2023-5590