Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Melissa K. Lantz"'
Autor:
Ajit S. Shah, Thomas Rogers, James Murphy, Bruce E. Wise, D. Keith Anderson, Harish K. Santhanam, Mark A. Pietz, H. Peter Kleine, Derek B. Brown, V. H. Iskos, Jerry D. Clark, Melissa K. Lantz, Christine M. V. Moore, David V. Banaszak, Peter G. Ruminski, Czyzewski Ann M, Carlos A. Orihuela, Puneh S. Forouzi, Carl M. Knable, Gerald A. Weisenburger, Frank W. Muellner, Mark A. Lapack, Schilke Tobin C, Donald J. Gallagher, Albert D. Edeny, Ahmad Y. Sheikh
Publikováno v:
Organic Process Research & Development. 13:1088-1093
Studies directed toward the process research, development, and scale-up preparation of the potential αvβ3 integrin antagonist 1 are described. A convergent approach is detailed wherein tetrahydropyrimidine hydroxybenzoic acid 2 is linked to the β-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::733dff69b6ebf02a64d61a4be7a9b658
https://doi.org/10.1021/op900173f
https://doi.org/10.1021/op900173f
Autor:
James W. Malecha, Christina N. Steininger, Melanie L. Williams, Kristen E. Shannon, Thomas Rogers, Bryan H. Landis, Tiffany Duffin, Srinivasan Nagarajan, Pegg Jodi Ann, Hwang-Fun Lu, Rico Joseph G, Maureen A. Nickols, Jun Zhu, Sandra K. Freeman, V. Wayne Engleman, David W. Griggs, G. Alan Nickols, Jeffery L. Keene, Devadas Balekudru, Debra M. Meyer, Marisa M. Westlin, Larry Miller, Laura D. Marrufo, Nawasa F. Green, Melissa K. Lantz, Mark A. Russell, Peter G. Ruminski, Mary Beth Finn, H. Peter Kleine, Joe T. Collins
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:3783-3800
The integrin αvβ3, vitronectin receptor, is expressed in a number of cell types and has been shown to mediate adhesion of osteoclasts to bone matrix, vascular smooth muscle cell migration, and angiogenesis. We recently disclosed the discovery of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8d38d74f8d90c225cd3716f76ef91f6
https://doi.org/10.1016/j.bmc.2007.03.034
https://doi.org/10.1016/j.bmc.2007.03.034
Autor:
Edney Albert D, Carl M. Knable, Pierre-Jean Colson, D. Keith Anderson, Thomas Rogers, Donald J. Gallagher, Ajit S. Shah, H. Peter Kleine, Jerry D. Clark, James Murphy, Christine M. V. Moore, Neil Storer, Bruce E. Wise, Peter G. Ruminski, Gerald A. Weisenburger, Melissa K. Lantz
Publikováno v:
Organic Process Research & Development. 8:51-61
Described are four process research investigations directed toward discerning a scalable, enantioselective method for preparing (S)-β-amino acid ester 3, a key intermediate to the αvβ3 integrin antagonist 1. Reported are an asymmetric Michael reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54f87a82dd31eb7ccfa9af86ec1e1272
https://doi.org/10.1021/op034094j
https://doi.org/10.1021/op034094j
Autor:
Srinivasan R, Nagarajan, Balekudru, Devadas, James W, Malecha, Hwang-Fun, Lu, Peter G, Ruminski, Joseph G, Rico, Thomas E, Rogers, Laura D, Marrufo, Joe T, Collins, H Peter, Kleine, Melissa K, Lantz, Jun, Zhu, Nawasa F, Green, Mark A, Russell, Bryan H, Landis, Lawrence M, Miller, Debra M, Meyer, Tiffany D, Duffin, V Wayne, Engleman, Mary B, Finn, Sandra K, Freeman, David W, Griggs, Melanie L, Williams, Maureen A, Nickols, Jodi A, Pegg, Kristen E, Shannon, Christina, Steininger, Marisa M, Westlin, G Alan, Nickols, Jeffery L, Keene
Publikováno v:
Bioorganicmedicinal chemistry. 15(11)
The integrin alpha(v)beta(3), vitronectin receptor, is expressed in a number of cell types and has been shown to mediate adhesion of osteoclasts to bone matrix, vascular smooth muscle cell migration, and angiogenesis. We recently disclosed the discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0a0bd91c9e67f6a65c308d5b53b9f248
https://pubmed.ncbi.nlm.nih.gov/17399986
https://pubmed.ncbi.nlm.nih.gov/17399986