Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Melissa Jane Fullwood"'
Autor:
Sinan Xiong, Jianbiao Zhou, Tze King Tan, Tae-Hoon Chung, Tuan Zea Tan, Sabrina Hui-Min Toh, Nicole Xin Ning Tang, Yunlu Jia, Yi Xiang See, Melissa Jane Fullwood, Takaomi Sanda, Wee-Joo Chng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Multiple myeloma is a hematological malignancy arising from immunoglobulin-secreting plasma cells. It remains poorly understood how chromatin rewiring of regulatory elements contributes to tumorigenesis and therapy resistance in myeloma. Her
Externí odkaz:
https://doaj.org/article/a72d588788c3426aa48efeac9ff0d625
Autor:
Harue Mizokami, Atsushi Okabe, Ruchi Choudhary, Masato Mima, Kenta Saeda, Masaki Fukuyo, Bahityar Rahmutulla, Motoaki Seki, Boon-Cher Goh, Satoru Kondo, Hirotomo Dochi, Makiko Moriyama-Kita, Kiyoshi Misawa, Toyoyuki Hanazawa, Patrick Tan, Tomokazu Yoshizaki, Melissa Jane Fullwood, Atsushi Kaneda
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105057- (2024)
Summary: Background: Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated malignant epithelial tumor endemic to Southern China and Southeast Asia. While previous studies have revealed a low frequency of gene mutations in NPC, its
Externí odkaz:
https://doaj.org/article/0d406c389ac048dea04ff8c3811564af
Autor:
Qiling Zhou, Miao Yu, Roberto Tirado-Magallanes, Bin Li, Lingshi Kong, Mingrui Guo, Zi Hui Tan, Sanghoon Lee, Li Chai, Akihiko Numata, Touati Benoukraf, Melissa Jane Fullwood, Motomi Osato, Bing Ren, Daniel G. Tenen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
CTCF mediates DNA–DNA interactions by forming dimers that directly bind to both sides of the DNA. Here the authors reveal that a CTCF known associated zinc finger, ZNF143, mediates gene transcription through CTCF–DNA binding to maintain murine he
Externí odkaz:
https://doaj.org/article/a828711a0de141af954d80bfa7285356
Autor:
Yichao Cai, Ying Zhang, Yan Ping Loh, Jia Qi Tng, Mei Chee Lim, Zhendong Cao, Anandhkumar Raju, Erez Lieberman Aiden, Shang Li, Lakshmanan Manikandan, Vinay Tergaonkar, Greg Tucker-Kellogg, Melissa Jane Fullwood
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Mechanisms underlying gene repression and silencers remain poorly understood. Here the authors investigate the role of H3K27me3-rich regions in the genome, as defined from clusters of H3K27me3 peaks, in regulating gene expression via looping.
Externí odkaz:
https://doaj.org/article/d3b2681ce73046bd90d6e3a3c6cb6762
Autor:
Sambhavi Animesh, Ruchi Choudhary, Bertrand Jern Han Wong, Charlotte Tze Jia Koh, Xin Yi Ng, Joshua Kai Xun Tay, Wan-Qin Chong, Han Jian, Leilei Chen, Boon Cher Goh, Melissa Jane Fullwood
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Nasopharyngeal cancer (NPC), a cancer derived from epithelial cells in the nasopharynx, is a cancer common in China, Southeast Asia, and Africa. The three-dimensional (3D) genome organization of nasopharyngeal cancer is poorly understood. A major cha
Externí odkaz:
https://doaj.org/article/4961c22232fc4e99a13d55b9b9aa4f7e
Publikováno v:
Cells, Vol 11, Iss 9, p 1560 (2022)
Three-dimensional genome organization represents an additional layer in the epigenetic regulation of gene expression. Active transcription controlled by enhancers or super-enhancers has been extensively studied. Enhancers or super-enhancers can recru
Externí odkaz:
https://doaj.org/article/5bfa888265534e5cbececb3c2c3f5e04
Autor:
Shweta Pradip Jadhav, Nishi Kumari, Larry Ng, Pei Fang Tan, Nicole Shu Ling Yeo-Teh, Yufen Goh, Wee Nih Fam, Jia Qi Tng, Johann Shane Tian, Bryan T. H. Koh, Chan Ming Chun, Wilson Wang, Wee Joo Chng, Melissa Jane Fullwood, Ernesto Guccione, Neerja Karnani, Daniel G. Tenen, Sudhakar Jha
Publikováno v:
Haematologica, Vol 105, Iss 7 (2020)
Externí odkaz:
https://doaj.org/article/c6d689f208794cfdb06ff5e2260d5be8
HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis
Autor:
TingDong Yan, Wen Fong Ooi, Aditi Qamra, Alice Cheung, DongLiang Ma, Gopinath Meenakshi Sundaram, Chang Xu, Manjie Xing, LaiFong Poon, Jing Wang, Yan Ping Loh, Jess Hui Jie Ho, Joscelyn Jun Quan Ng, Muhammad Khairul Ramlee, Luay Aswad, Steve G. Rozen, Sujoy Ghosh, Frederic A. Bard, Prabha Sampath, Vinay Tergaonkar, James O. J. Davies, Jim R. Hughes, Eyleen Goh, Xuezhi Bi, Melissa Jane Fullwood, Patrick Tan, Shang Li
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The expression of telomerase catalytic subunit hTERT is frequently upregulated in many cancers. Here, the authors show HoxC5 and miR-615-3p can negatively regulate hTERT to impede tumorigenesis by targeting the newly evolved cis-regulatory genomic el
Externí odkaz:
https://doaj.org/article/277e679dd3d749c1b6f4ca18ea150063
Autor:
Vinay Tergaonkar, Melissa Jane Fullwood, Bilal Unal, Priscilla Li Shan Boon, Ekta Khattar, Semih Can Akıncılar
Supplementary figures and legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74448246f12441457cb3d7365b3ecadc
https://doi.org/10.1158/2159-8290.22531092.v1
https://doi.org/10.1158/2159-8290.22531092.v1
Autor:
Vinay Tergaonkar, Melissa Jane Fullwood, Bilal Unal, Priscilla Li Shan Boon, Ekta Khattar, Semih Can Akıncılar
Supplementary Table 1. Differential gene expression data list of BLM6 and BLM14 cells (-146C>T vs. -146C) for the genes that were predicted to be off-targets of the guide RNA that has been used for the CRISPR/Cas9 genome engineering. Supplementary Ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60842b66e8211115171a0725e30bea7a
https://doi.org/10.1158/2159-8290.22531089
https://doi.org/10.1158/2159-8290.22531089