Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Melissa J. Peart"'
Publikováno v:
Molecular and Cellular Biology. 29:3953-3963
p63, a member of the p53 tumor suppressor family, is essential for the development of epidermis as well as other stratified epithelia. Collective evidence indicates that DeltaNp63 proteins, the N-terminally deleted versions of p63, are essential for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1263cda365981cf21ff13454728afc
https://doi.org/10.1128/mcb.00449-09
https://doi.org/10.1128/mcb.00449-09
Autor:
Leonie A. Cluse, K. Whitecross, Andrea Newbold, Amber E. Alsop, Kellie-Marie Banks, Ricky W. Johnstone, Claudia P. Coomans, Adrian Wiegmans, Melissa J. Peart, Ralph K. Lindemann
Publikováno v:
Blood. 113:1982-1991
The apoptotic and therapeutic activities of the histone deacetylase inhibitor (HDACi) vorinostat are blocked by overexpresssion of Bcl-2 or Bcl-XL. Herein, we used the small molecule inhibitor ABT-737 to restore sensitivity of Eμ-myc lymphomas overe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5e6bcee8c2a4503b2d3575574f589f
https://doi.org/10.1182/blood-2008-05-156851
https://doi.org/10.1182/blood-2008-05-156851
Publikováno v:
Nature Reviews Drug Discovery. 5:769-784
Histone deacetylases (HDACs) are enzymes involved in the remodelling of chromatin, and have a key role in the epigenetic regulation of gene expression. In addition, the activity of non-histone proteins can be regulated through HDAC-mediated hypo-acet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa071e70c9847a3cc8d4c9c34c0e6781
https://doi.org/10.1038/nrd2133
https://doi.org/10.1038/nrd2133
Autor:
Paul A. Marks, Andrew J. Holloway, Ryan van Laar, Victoria M. Richon, Gordon K. Smyth, Ricky W. Johnstone, David D.L. Bowtell, Melissa J. Peart
Publikováno v:
Proceedings of the National Academy of Sciences. 102:3697-3702
Histone deacetylase inhibitors (HDACis) inhibit tumor cell growth and survival, possibly through their ability to regulate the expression of specific proliferative and/or apoptotic genes. However, the HDACi-regulated genes necessary and/or sufficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e36b56ac67af301dae74688d48ea797f
https://doi.org/10.1073/pnas.0500369102
https://doi.org/10.1073/pnas.0500369102
Autor:
Melissa J. Peart, Carol Prives, Elizabeth M Kass, Marshall Urist, Peter K. Jackson, Masha V. Poyurovsky, Matthew K. Summers, Emmy W. Verschuren
Publikováno v:
Cell cycle (Georgetown, Tex.). 9(20)
The mechanisms that control E2F-1 activity are complex. We previously showed that Chk1 and Chk2 are required for E2F1 stabilization and p73 target gene induction following DNA damage. To gain further insight into the processes regulating E2F1 protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::399b608a7083de030ef84723bbb29f69
https://pubmed.ncbi.nlm.nih.gov/20980832
https://pubmed.ncbi.nlm.nih.gov/20980832
Autor:
Melissa J. Peart, James L. Manley, Carol Prives, Rachel Beckerman, Melissa Mattia, Joaquín M. Espinosa, Aaron J Donner
We reported previously that when cells are arrested in S phase, a subset of p53 target genes fails to be strongly induced despite the presence of high levels of p53. When DNA replication is inhibited, reduced p21 mRNA accumulation is correlated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ee339159ea01a553b207fc1553b8ca
https://europepmc.org/articles/PMC2701578/
https://europepmc.org/articles/PMC2701578/
Publikováno v:
Molecular and cellular biology. 29(3)
Although the cyclin G1 gene is known to be regulated at the transcriptional level by p53, less is understood about the turnover of its protein product. We found that ectopically and endogenously expressed cyclin G1 protein is highly unstable and is d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c189b9e9f672772971f6d20afd0af4fe
https://pubmed.ncbi.nlm.nih.gov/18981217
https://pubmed.ncbi.nlm.nih.gov/18981217
Autor:
Suzanne Hasthorpe, Kellie M. Tainton, John M. Hutson, Kelly N. Roeszler, Martin J. Tymms, Patricia E. Lusby, Katrina M. Bell, Melissa J. Peart
Publikováno v:
Molecular reproduction and development. 74(5)
Cell cycle progression is prevented by signal transduction pathways known as checkpoints which are activated in response to replication interference and DNA damage. We cloned a G2/M cell cycle phase-related checkpoint gene from a neonatal mouse testi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::443e12e91e3325adf6c72982478b646a
https://pubmed.ncbi.nlm.nih.gov/17290426
https://pubmed.ncbi.nlm.nih.gov/17290426
Autor:
Melissa J, Peart, Kellie M, Tainton, Astrid A, Ruefli, Anthony E, Dear, Karin A, Sedelies, Lorraine A, O'Reilly, Nigel J, Waterhouse, Joseph A, Trapani, Ricky W, Johnstone
Publikováno v:
Cancer research. 63(15)
Histone deacetylase inhibitors (HDACIs) are a new class of chemotherapeutic drugs able to induce tumor cell apoptosis and/or cell cycle arrest; however, the molecular mechanisms underpinning their anticancer effects are poorly understood. Herein, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c9da58c239440a0016249f497e6fff2
https://pubmed.ncbi.nlm.nih.gov/12907619
https://pubmed.ncbi.nlm.nih.gov/12907619