Výsledky vyhledávání - "Melissa J. Nicholson"

Small Molecules That Enhance the Catalytic Efficiency of HLA-DM

Autor: Gregory D. Cuny, Ross L. Stein, Nilufer P. Seth, Melissa J. Nicholson, Xuechao Xing, Kai W. Wucherpfennig, Babak Moradi

Publikováno v: The Journal of Immunology. 176:4208-4220

HLA-DM (DM) plays a critical role in Ag presentation to CD4 T cells by catalyzing the exchange of peptides bound to MHC class II molecules. Large lateral surfaces involved in the DM:HLA-DR (DR) interaction have been defined, but the mechanism of cata

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ca8aa6c313958dceb5c97a3aff91ff
https://doi.org/10.4049/jimmunol.176.7.4208

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Unconventional topology of self peptide–major histocompatibility complex binding by a human autoimmune T cell receptor

Autor: Jason Pyrdol, Michael Hahn, Melissa J. Nicholson, Kai W. Wucherpfennig

Publikováno v: Nature Immunology. 6:490-496

Autoimmune diseases are caused by self-reactive lymphocytes that have escaped deletion. Here we have determined the structure of the trimolecular complex for a T cell receptor (TCR) from a patient with multiple sclerosis that causes autoimmunity in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e42fe1f0df78b0050952a8cbb4f69135
https://doi.org/10.1038/ni1187

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Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association

Autor: Maxine Yang, Arup K. Chakraborty, Kai W. Wucherpfennig, Kathrin Wilbuer, Gijsbert M. Grotenbreg, Melissa J. Nicholson, Leah M. Octavio, Kevin D. Fowler, Hidde L. Ploegh

Publikováno v: The Journal of biological chemistry. 282(29)

DM catalyzes the exchange of peptides bound to Class II major histocompatibility complex (MHC) molecules. Because the dissociation and association components of the overall reaction are difficult to separate, a detailed mechanism of DM catalysis has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc48a0b5c041cb7e8fdb633dd1d620d
https://pubmed.ncbi.nlm.nih.gov/17525157

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Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1

Autor: Beenu Moza, John K. McCormick, Penny Zhu, Christine A. Herfst, David M. Kranz, Anne Kathrin Wilbuer, Rebecca A. Buonpane, Kai W. Wucherpfennig, Eric J. Sundberg, Nilufer P. Seth, Melissa J. Nicholson, Ashok K. Varma

Publikováno v: The EMBO journal. 26(4)

Superantigens (SAGs) bind simultaneously to major histocompatibility complex (MHC) and T-cell receptor (TCR) molecules, resulting in the massive release of inflammatory cytokines that can lead to toxic shock syndrome (TSS) and death. A major causativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456eb9fb4d94089a3c4c871355bb89a0
https://pubmed.ncbi.nlm.nih.gov/17268555

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Unusual Features of Self-Peptide/MHC Binding by Autoimmune T Cell Receptors

Autor: Kai W. Wucherpfennig, Michael Hahn, Melissa J. Nicholson

Structural studies on T cell receptors (TCRs) specific for foreign antigens demonstrated a remarkably similar topology characterized by a central, diagonal TCR binding mode that maximizes interactions with the MHC bound peptide. However, three recent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c323836a8af2e7650a85f96125f3532
https://europepmc.org/articles/PMC3417822/

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