Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Melissa J. Mahoney"'
Publikováno v:
Acta Biomaterialia. 22:103-110
This study aimed to develop a three dimensional culture platform for aggregates of human embryonic stem cell (hESC)-derived pancreatic progenitors that enables long-term culture, maintains aggregate size and morphology, does not adversely affect diff
Publikováno v:
Tissue Engineering Part B: Reviews. 20:455-467
Type 1 diabetes mellitus is an autoimmune disease resulting from the destruction of insulin-producing pancreatic β-cells. Cell-based therapies, involving the transplantation of functional β-cells into diabetic patients, have been explored as a pote
Autor:
Steven F. Maier, Melissa J. Mahoney, Anne Marie van Dam, Peter M. Grace, John P. Christianson, Linda R. Watkins, Kathryn R. Penzkover, Raymond A. Chavez, Johanna G. Flyer-Adams, Keith A. Strand, John Forsayeth, Lisa C. Loram
Publikováno v:
Grace, P M, Loram, L C, Christianson, J P, Strand, K A, Flyer-Adams, J G, Penzkover, K R, Forsayeth, J R, van Dam, A M, Mahoney, M J, Maier, S F, Chavez, R A & Watkins, L R 2017, ' Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy ', Brain, Behavior, and Immunity, vol. 59, pp. 49-54 . https://doi.org/10.1016/j.bbi.2016.05.012
Brain, Behavior, and Immunity, 59, 49-54. Academic Press Inc.
Brain, Behavior, and Immunity, 59, 49-54. Academic Press Inc.
Relapsing-remitting multiple sclerosis is commonly associated with motor impairments, neuropathic pain, fatigue, mood disorders, and decreased life expectancy. However, preclinical pharmacological studies predominantly rely on clinical scoring of mot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbe7217fa85fb3f070e01af6fbcb206
https://escholarship.org/uc/item/9zz0h3pk
https://escholarship.org/uc/item/9zz0h3pk
Publikováno v:
Journal of Biomedical Materials Research Part A. :595-607
Tailored delivery of neurotrophic factors (NFs) is a critical challenge that continues to inhibit strategies for guidance of axonal growth in vivo. Of particular importance is the ability to recreate innervation of distant brain regions by transplant
Autor:
Ryan G. Soderquist, Melissa J. Mahoney
Publikováno v:
Expert Opinion on Drug Delivery. 7:285-293
Therapeutic proteins and DNA constructs offer promise for the treatment of central nervous system disorders, yet significant biological barriers limit the ability of these molecules to reach the central nervous system from the bloodstream. Direct adm
Autor:
Magdalene J. Seiler, Robert B. Aramant, Mathias W. Seeliger, Kristina Narfström, Melissa J. Mahoney, Ragnheidur Bragadottir
Publikováno v:
Veterinary Ophthalmology. 12:158-169
Purpose To investigate whether sheets of fetal retinal allografts can integrate into the dystrophic Abyssinian cat retina with progressive rod cone degeneration. Methods Fetal retinal sheets (cat gestational day 42), incubated with BDNF microspheres,
Autor:
John R. Sladek, D.E. Redmond, Kimberly B. Bjugstad, Kyle J. Lampe, Drew S. Kern, Melissa J. Mahoney
Publikováno v:
Cell Transplantation, Vol 17 (2008)
Degradable polymers have been used successfully in a wide variety of peripheral applications from tissue regeneration to drug delivery. These polymers induce little inflammatory response and appear to be well accepted by the host environment. Their u
Autor:
Biju B. Thomas, Robert B. Aramant, Magdalene J. Seiler, Melissa J. Mahoney, Zhenhai Chen, Srinivas R. Sadda, S. Arai, Sridhar Chadalavada
Publikováno v:
Experimental eye research, vol 86, iss 1
Seiler, MJ; Thomas, BB; Chen, Z; Arai, S; Chadalavada, S; Mahoney, MJ; et al.(2008). BDNF-treated retinal progenitor sheets transplanted to degenerate rats: Improved restoration of visual function. Experimental Eye Research, 86(1), 92-104. doi: 10.1016/j.exer.2007.09.012. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5928b701
Seiler, MJ; Thomas, BB; Chen, Z; Arai, S; Chadalavada, S; Mahoney, MJ; et al.(2008). BDNF-treated retinal progenitor sheets transplanted to degenerate rats: Improved restoration of visual function. Experimental Eye Research, 86(1), 92-104. doi: 10.1016/j.exer.2007.09.012. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5928b701
The aim of this study was to evaluate the functional efficacy of retinal progenitor cell (RPC) containing sheets with BDNF microspheres following subretinal transplantation in a rat model of retinal degeneration. Sheets of E19 RPCs derived from human
Publikováno v:
Expert Opinion on Biological Therapy. 6:847-866
The human body contains a variety of stem cells capable of both repeated self-renewal and production of specialised, differentiated progeny. Critical to the implementation of these cells in tissue engineering strategies is a thorough understanding of
Publikováno v:
Bioconjugate Chemistry. 10:932-937
Conjugation of poly(ethylene glycol) derivatives with therapeutic proteins is a promising approach for enhancing protein stability and, therefore, effectiveness. An N-hydroxysuccinimidyl ester of fluorescein-PEG 2000 was used for chemical modificatio