Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Melissa J. Buskes"'
Autor:
Lori Ferrins, Melissa J. Buskes, Madison M. Kapteyn, Hannah N. Engels, Suzanne E. Enos, Chenyang Lu, Dana M. Klug, Baljinder Singh, Antonio Quotadamo, Kelly Bachovchin, Westley F. Tear, Andrew E. Spaulding, Katherine C. Forbes, Seema Bag, Mitch Rivers, Catherine LeBlanc, Erin Burchfield, Jeremy R. Armand, Rosario Diaz-Gonzalez, Gloria Ceballos-Perez, Raquel García-Hernández, Guiomar Pérez-Moreno, Cristina Bosch-Navarrete, Claudia Gómez-Liñán, Luis Miguel Ruiz-Pérez, Francisco Gamarro, Dolores González-Pacanowska, Miguel Navarro, Kojo Mensa-Wilmot, Michael P. Pollastri, Dennis E. Kyle, Christopher A. Rice
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/0f2b847142f74e518b6ce0db61ac7a90
Autor:
Lori Ferrins, Melissa J. Buskes, Madison M. Kapteyn, Hannah N. Engels, Suzanne E. Enos, Chenyang Lu, Dana M. Klug, Baljinder Singh, Antonio Quotadamo, Kelly Bachovchin, Westley F. Tear, Andrew E. Spaulding, Katherine C. Forbes, Seema Bag, Mitch Rivers, Catherine LeBlanc, Erin Burchfield, Jeremy R. Armand, Rosario Diaz-Gonzalez, Gloria Ceballos-Perez, Raquel García-Hernández, Guiomar Pérez-Moreno, Cristina Bosch-Navarrete, Claudia Gómez-Liñán, Luis Miguel Ruiz-Pérez, Francisco Gamarro, Dolores González-Pacanowska, Miguel Navarro, Kojo Mensa-Wilmot, Michael P. Pollastri, Dennis E. Kyle, Christopher A. Rice
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Acanthamoeba species, Naegleria fowleri, and Balamuthia mandrillaris are opportunistic pathogens that cause a range of brain, skin, eye, and disseminated diseases in humans and animals. These pathogenic free-living amoebae (pFLA) are commonly misdiag
Externí odkaz:
https://doaj.org/article/d32dd50bf4c74ebf995a90e8b2cf426f
Publikováno v:
ACS Medicinal Chemistry Letters. 14:376-385
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98fb1bd908bfb599d1e4ccc2ac1e3796
https://doi.org/10.1021/acsmedchemlett.3c00012
https://doi.org/10.1021/acsmedchemlett.3c00012
Autor:
Melissa J. Buskes, Maria-Jesus Blanco
Publikováno v:
Molecules, Vol 25, Iss 15, p 3493 (2020)
Cross-coupling reactions have played a critical role enabling the rapid expansion of structure–activity relationships (SAR) during the drug discovery phase to identify a clinical candidate and facilitate subsequent drug development processes. The r
Externí odkaz:
https://doaj.org/article/6e6c0c86ad36428793fa629c05c73eb0
Autor:
Julia Medeiros Souza, Everton M Silva, Jessey Erath, Diane Thomas, James H. McKerrow, Lori Ferrins, Baljinder Singh, Erica Penn, Robert F. Campbell, Jair L. Siqueira-Neto, Ana Rodriguez, Jean A. Bernatchez, Susan E. Leed, Norma Roncal, Hitesh B. Jalani, Jasmin Ackermann, Michael P. Pollastri, Dana M. Klug, Laura-Isobel McCall, Kelly A. Bachovchin, Claudia M. Calvet, Richard J. Sciotti, Seema Bag, Melissa J. Buskes
Publikováno v:
ACS Med Chem Lett
[Image: see text] Utilizing a target repurposing and parasite-hopping approach, we tested a previously reported library of compounds that were active against Trypanosoma brucei, plus 31 new compounds, against a variety of protozoan parasites includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd9aed31503ad64e9e28813b5711662c
https://doi.org/10.1021/acsmedchemlett.9b00453
https://doi.org/10.1021/acsmedchemlett.9b00453
Autor:
Lori Ferrins, Melissa J. Buskes, Conor R. Caffrey, Hitesh B. Jalani, Dana M. Klug, Kelly A. Bachovchin, Nelly El-Sakkary, Allison Leonard, Baljinder Singh, Robert F. Campbell, Michael P. Pollastri, Richard J. Sciotti, Seema Bag, Monica Clements
Publikováno v:
ACS Medicinal Chemistry Letters
We recently reported a series of compounds for a solubility-driven optimization campaign of antitrypanosomal compounds. Extending a parasite-hopping approach to the series, a subset of compounds from this library has been cross-screened for activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8ee50ddcb2576fc6178e843d54b7e1
http://europepmc.org/articles/PMC7073886
http://europepmc.org/articles/PMC7073886
Autor:
Maria-Jesus Blanco, Melissa J Buskes
Publikováno v:
Molecules, Vol 25, Iss 3493, p 3493 (2020)
Molecules
Molecules
Cross-coupling reactions have played a critical role enabling the rapid expansion of structure–activity relationships (SAR) during the drug discovery phase to identify a clinical candidate and facilitate subsequent drug development processes. The r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c85bb3a3873d64a26feed409f8ceab6b
https://www.mdpi.com/1420-3049/25/15/3493
https://www.mdpi.com/1420-3049/25/15/3493
Autor:
Miguel Navarro, Quillon J. Simpson, Travis J. DeLano, Maria Santos Martinez-Martinez, Raquel García-Hernández, Rosario Diaz-Gonzalez, Westley Tear, Guiomar Pérez-Moreno, William G. Devine, Lori Ferrins, Dolores González-Pacanowska, Luis M. Ruiz-Pérez, Melanie G. Fritsche, Katherine M. Schneider, Michael P. Pollastri, Francisco Gamarro, John K. Fisher, Cristina Bosch-Navarrete, Pilar Manzano-Chinchon, Vivian Hilborne, Dana M. Klug, Raeann M. Dalton, Gloria Ceballos-Pérez, Eftychia M. Mavrogiannaki, Melissa J. Buskes
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
RSC Med Chem
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
RSC Med Chem
Human African trypanosomiasis is a neglected tropical disease (NTD) that is fatal if left untreated. Although approximately 13 million people live in moderate- to high-risk areas for infection, current treatments are plagued by problems with safety,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c419df9071d8f28b3bdefbdbcc538de7
http://hdl.handle.net/10261/246477
http://hdl.handle.net/10261/246477
Autor:
Robabeh Kalhor, Paul R. Gilson, Kiaran Kirk, Alan F. Cowman, Adele M. Lehane, Anthony T. Papenfuss, Tania F. de Koning-Ward, Mark D. Hulett, Rasika Kumarasingha, Jennifer K. Thompson, Jessica K. Holien, Belinda M. Abbott, Madeline G Dans, Jocelyn Sietsma Penington, Xinxin Zhang, Hayley E Bullen, Melissa J. Buskes, Brendan S. Crabb, Tatiana P. Soares da Costa
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
We developed a novel series of antimalarial compounds based on a 4-cyano-3-methylisoquinoline. Our lead compound MB14 achieved modest inhibition of the growth in vitro of the human malaria parasite, Plasmodium falciparum. To identify its biological t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da2db203f56119a2708aeaad5739853
https://doi.org/10.1038/s41598-019-46500-5
https://doi.org/10.1038/s41598-019-46500-5
Autor:
Dana M. Klug, Richard J. Sciotti, Baljinder Singh, Seema Bag, Kojo Mensa-Wilmot, Jeremiah D. Momper, Hitesh B. Jalani, Ana Rodriguez, Melissa J. Buskes, Kelly A. Bachovchin, Katherine M. Schneider, Michael P. Pollastri, Scott Tanghe, Lori Ferrins, Amrita Sharma, Naimee Mehta
Publikováno v:
Journal of medicinal chemistry, vol 62, iss 2
Lapatinib, an approved epidermal growth factor receptor inhibitor, was explored as a starting point for the synthesis of new hits against Trypanosoma brucei, the causative agent of human African trypanosomiasis (HAT). Previous work culminated in 1 (N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9d04f11b4d25eb3432d3d37479f934
https://escholarship.org/uc/item/0qv0q4v1
https://escholarship.org/uc/item/0qv0q4v1