Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Melissa J Grimm"'
Autor:
Lauren Williams, Paul K Wallace, Pawel Kalinski, Mateusz Opyrchal, Kathleen M Kokolus, Shipra Gandhi, Kristopher Attwood, Agnieszka Witkiewicz, Hans Minderman, Kah Teong Soh, Melissa J Grimm, Ronald T Slomba, Adrienne Groman, Mary Lynne Tarquini, Orla Maguire, Tracey L O’Connor, Amy P Early, Ellis G Levine
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 11 (2023)
Background Presence of cytotoxic T lymphocytes (CTL) in the tumor microenvironment (TME) predicts the effectiveness of cancer immunotherapies. The ability of toll-like receptor 3 (TLR3) ligands, interferons (IFNs) and COX2 inhibitors to synergistical
Externí odkaz:
https://doaj.org/article/2d1ecf8be6c34222ae25dc9f47cf3dc6
Autor:
Kiyoshi Itagaki, Elzbieta Kaczmarek, Yen Ting Lee, I Tien Tang, Burak Isal, Yashar Adibnia, Nicola Sandler, Melissa J Grimm, Brahm H Segal, Leo E Otterbein, Carl J Hauser
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120549 (2015)
Neutrophil extracellular traps (NETs) are critical for anti-bacterial activity of the innate immune system. We have previously shown that mitochondrial damage-associated molecular patterns (mtDAMPs), including mitochondrial DNA (mtDNA), are released
Externí odkaz:
https://doaj.org/article/3401ac467a084b0ea20497d412e5f42f
Autor:
Heidi E Godoy, A Nazmul H Khan, R Robert Vethanayagam, Melissa J Grimm, Kelly L Singel, Nonna Kolomeyevskaya, Kevin J Sexton, Anupama Parameswaran, Scott I Abrams, Kunle Odunsi, Brahm H Segal
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69631 (2013)
The phagocyte NADPH oxidase generates superoxide anion and downstream reactive oxidant intermediates in response to infectious threat, and is a critical mediator of antimicrobial host defense and inflammatory responses. Myeloid-derived suppressor cel
Externí odkaz:
https://doaj.org/article/fc54a686ef584b7392783cc45292ce79
Autor:
R Robert Vethanayagam, Nikolaos G Almyroudis, Melissa J Grimm, David C Lewandowski, Christine T N Pham, Timothy S Blackwell, Ruta Petraitiene, Vidmantas Petraitis, Thomas J Walsh, Constantin F Urban, Brahm H Segal
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28149 (2011)
NADPH oxidase is a crucial enzyme in mediating antimicrobial host defense and in regulating inflammation. Patients with chronic granulomatous disease, an inherited disorder of NADPH oxidase in which phagocytes are defective in generation of reactive
Externí odkaz:
https://doaj.org/article/a6128003d5c948158e09d6dfa035f664
Autor:
K.S. Grzankowski, Zsuzsanna Környei, Rebeka Fekete, P.C. Mayor, Constantin F. Urban, Kelly L. Singel, Tiffany R. Emmons, Kunle Odunsi, Uma Muthukrishnan, Cynthia A. Leifer, Anthony C. D'Auria, Adam Denes, Kirsten B. Moysich, Kevin H. Eng, Kayla Morrell, Melissa J. Grimm, Nikolett Lénárt, Kiyoshi Itagaki, Carl J. Hauser, Bonnie L. Hylander, Brahm H. Segal, Jonathan D. Gilthorpe, A. Nazmul H. Khan
Publikováno v:
British Journal of Cancer
BACKGROUND: Advanced cancer causes necrosis and releases damage-associated molecular patterns (DAMPs). Mitochondrial DAMPs activate neutrophils, including generation of neutrophil extracellular traps (NETs), which are injurious, thrombogenic, and imp
Autor:
Patrick M Boland, Sarbajit Mukherjee, Melissa J. Grimm, Kristopher Attwood, Pawel Kalinski, Medhavi Gupta
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background CRC remains the 2nd most common cause of cancer-related death in the US. Hepatic metastases develop in 20–50% of CRC patients.1 Median overall survival (OS) of patients with metastatic CRC is poor, even with the advent of biologics. A hi
Autor:
Victoria Fitzpatrick, Mateusz Opyrchal, Per H. Basse, Tracey O'Connor, Kristopher Attwood, Marc S. Ernstoff, Amy P. Early, Shipra Gandhi, Marie Quinn, Agnieszka K. Witkiewicz, Cayla Ford, Ellis G. Levine, Melissa J. Grimm, Pawel Kalinski
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Neoadjuvant chemotherapy (NAC) with taxanes is the standard of care in triple negative breast cancer (TNBC). Intratumoral prevalence of CD8+ cytotoxic T-lymphocytes (CTLs) is associated with an improvement in relapse-free survival (RFS) an
Autor:
Saigopalakrishna S. Yerneni, Robert P. Edwards, Jamie Voyten, Melissa J. Grimm, B.C. Orr, Francesmary Modugno, Ravikumar Muthuswamy, David L. Bartlett, Saumendra N. Sarkar, Pawel Kalinski, Marie-Nicole Theodoraki, Weijian Jiang, Per H. Basse
Presence of cytotoxic CD8+ T cells (CTL) in tumor microenvironments (TME) is critical for the effectiveness of immune therapies and patients' outcome, whereas regulatory T(reg) cells promote cancer progression. Immune adjuvants, including double-stra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2cf51a5709875139fc346a95e6898a4
https://europepmc.org/articles/PMC6636317/
https://europepmc.org/articles/PMC6636317/
A role for the thermal environment in defining co-stimulation requirements for CD4+T cell activation
Autor:
Elizabeth A. Repasky, Evan R. Zynda, Julie R. Ostberg, Maegan L. Capitano, Thomas A. Mace, Melissa J. Grimm, Arnd Pralle, Lingwen Zhong, Min Yuan, Kelvin P. Lee
Publikováno v:
Cell Cycle. 14:2340-2354
Maintenance of normal core body temperature is vigorously defended by long conserved, neurovascular homeostatic mechanisms that assist in heat dissipation during prolonged, heat generating exercise or exposure to warm environments. Moreover, during f
Autor:
Brahm H. Segal, Melissa J. Grimm
Publikováno v:
Immunogenetics of Fungal Diseases ISBN: 9783319508405
The phagocyte NADPH oxidase is rapidly activated as an emergency response to infection. Activation of the NADPH oxidase requires translocation of cytoplasmic constituents to a membrane-bound flavocytochrome, and results in the conversion of molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ecf9326ea66a2dd5b8a79c213c7a440
https://doi.org/10.1007/978-3-319-50842-9_4
https://doi.org/10.1007/978-3-319-50842-9_4