Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Melissa J Grimm"'
Autor:
Lauren Williams, Paul K Wallace, Pawel Kalinski, Mateusz Opyrchal, Kathleen M Kokolus, Shipra Gandhi, Kristopher Attwood, Agnieszka Witkiewicz, Hans Minderman, Kah Teong Soh, Melissa J Grimm, Ronald T Slomba, Adrienne Groman, Mary Lynne Tarquini, Orla Maguire, Tracey L O’Connor, Amy P Early, Ellis G Levine
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 11 (2023)
Background Presence of cytotoxic T lymphocytes (CTL) in the tumor microenvironment (TME) predicts the effectiveness of cancer immunotherapies. The ability of toll-like receptor 3 (TLR3) ligands, interferons (IFNs) and COX2 inhibitors to synergistical
Externí odkaz:
https://doaj.org/article/2d1ecf8be6c34222ae25dc9f47cf3dc6
Autor:
Kiyoshi Itagaki, Elzbieta Kaczmarek, Yen Ting Lee, I Tien Tang, Burak Isal, Yashar Adibnia, Nicola Sandler, Melissa J Grimm, Brahm H Segal, Leo E Otterbein, Carl J Hauser
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120549 (2015)
Neutrophil extracellular traps (NETs) are critical for anti-bacterial activity of the innate immune system. We have previously shown that mitochondrial damage-associated molecular patterns (mtDAMPs), including mitochondrial DNA (mtDNA), are released
Externí odkaz:
https://doaj.org/article/3401ac467a084b0ea20497d412e5f42f
Autor:
Despoina Kaloriti, Mette Jacobsen, Zhikang Yin, Miranda Patterson, Anna Tillmann, Deborah A. Smith, Emily Cook, Tao You, Melissa J. Grimm, Iryna Bohovych, Celso Grebogi, Brahm H. Segal, Neil A. R. Gow, Ken Haynes, Janet Quinn, Alistair J. P. Brown
Publikováno v:
mBio, Vol 5, Iss 4 (2014)
ABSTRACT Immune cells exploit reactive oxygen species (ROS) and cationic fluxes to kill microbial pathogens, such as the fungus Candida albicans. Yet, C. albicans is resistant to these stresses in vitro. Therefore, what accounts for the potent antifu
Externí odkaz:
https://doaj.org/article/4dfb09531b17429f9de94c33d6f04296
Autor:
K.S. Grzankowski, Zsuzsanna Környei, Rebeka Fekete, P.C. Mayor, Constantin F. Urban, Kelly L. Singel, Tiffany R. Emmons, Kunle Odunsi, Uma Muthukrishnan, Cynthia A. Leifer, Anthony C. D'Auria, Adam Denes, Kirsten B. Moysich, Kevin H. Eng, Kayla Morrell, Melissa J. Grimm, Nikolett Lénárt, Kiyoshi Itagaki, Carl J. Hauser, Bonnie L. Hylander, Brahm H. Segal, Jonathan D. Gilthorpe, A. Nazmul H. Khan
Publikováno v:
British Journal of Cancer
BACKGROUND: Advanced cancer causes necrosis and releases damage-associated molecular patterns (DAMPs). Mitochondrial DAMPs activate neutrophils, including generation of neutrophil extracellular traps (NETs), which are injurious, thrombogenic, and imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38122abe7c54e8bf0b23e24fea38523a
http://europepmc.org/articles/PMC6342981
http://europepmc.org/articles/PMC6342981
Autor:
Heidi E Godoy, A Nazmul H Khan, R Robert Vethanayagam, Melissa J Grimm, Kelly L Singel, Nonna Kolomeyevskaya, Kevin J Sexton, Anupama Parameswaran, Scott I Abrams, Kunle Odunsi, Brahm H Segal
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69631 (2013)
The phagocyte NADPH oxidase generates superoxide anion and downstream reactive oxidant intermediates in response to infectious threat, and is a critical mediator of antimicrobial host defense and inflammatory responses. Myeloid-derived suppressor cel
Externí odkaz:
https://doaj.org/article/fc54a686ef584b7392783cc45292ce79
Autor:
Patrick M Boland, Sarbajit Mukherjee, Melissa J. Grimm, Kristopher Attwood, Pawel Kalinski, Medhavi Gupta
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background CRC remains the 2nd most common cause of cancer-related death in the US. Hepatic metastases develop in 20–50% of CRC patients.1 Median overall survival (OS) of patients with metastatic CRC is poor, even with the advent of biologics. A hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db657a6d2a4cc9c3387d08b003f2a516
https://doaj.org/article/f323a00a97fb41ecaea12d4a5d522fb0
https://doaj.org/article/f323a00a97fb41ecaea12d4a5d522fb0
Autor:
Victoria Fitzpatrick, Mateusz Opyrchal, Per H. Basse, Tracey O'Connor, Kristopher Attwood, Marc S. Ernstoff, Amy P. Early, Shipra Gandhi, Marie Quinn, Agnieszka K. Witkiewicz, Cayla Ford, Ellis G. Levine, Melissa J. Grimm, Pawel Kalinski
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Neoadjuvant chemotherapy (NAC) with taxanes is the standard of care in triple negative breast cancer (TNBC). Intratumoral prevalence of CD8+ cytotoxic T-lymphocytes (CTLs) is associated with an improvement in relapse-free survival (RFS) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eac885bd79c9058aaf77332a546516b
https://doaj.org/article/547376769b9d43e9bd764f8c5446c5e0
https://doaj.org/article/547376769b9d43e9bd764f8c5446c5e0
Autor:
R Robert Vethanayagam, Nikolaos G Almyroudis, Melissa J Grimm, David C Lewandowski, Christine T N Pham, Timothy S Blackwell, Ruta Petraitiene, Vidmantas Petraitis, Thomas J Walsh, Constantin F Urban, Brahm H Segal
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28149 (2011)
NADPH oxidase is a crucial enzyme in mediating antimicrobial host defense and in regulating inflammation. Patients with chronic granulomatous disease, an inherited disorder of NADPH oxidase in which phagocytes are defective in generation of reactive
Externí odkaz:
https://doaj.org/article/a6128003d5c948158e09d6dfa035f664
Autor:
Saigopalakrishna S. Yerneni, Robert P. Edwards, Jamie Voyten, Melissa J. Grimm, B.C. Orr, Francesmary Modugno, Ravikumar Muthuswamy, David L. Bartlett, Saumendra N. Sarkar, Pawel Kalinski, Marie-Nicole Theodoraki, Weijian Jiang, Per H. Basse
Presence of cytotoxic CD8+ T cells (CTL) in tumor microenvironments (TME) is critical for the effectiveness of immune therapies and patients' outcome, whereas regulatory T(reg) cells promote cancer progression. Immune adjuvants, including double-stra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2cf51a5709875139fc346a95e6898a4
https://europepmc.org/articles/PMC6636317/
https://europepmc.org/articles/PMC6636317/
A role for the thermal environment in defining co-stimulation requirements for CD4+T cell activation
Autor:
Elizabeth A. Repasky, Evan R. Zynda, Julie R. Ostberg, Maegan L. Capitano, Thomas A. Mace, Melissa J. Grimm, Arnd Pralle, Lingwen Zhong, Min Yuan, Kelvin P. Lee
Publikováno v:
Cell Cycle. 14:2340-2354
Maintenance of normal core body temperature is vigorously defended by long conserved, neurovascular homeostatic mechanisms that assist in heat dissipation during prolonged, heat generating exercise or exposure to warm environments. Moreover, during f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1530837240661451ef46084768ede6
https://doi.org/10.1080/15384101.2015.1049782
https://doi.org/10.1080/15384101.2015.1049782