Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Melissa J Caimano"'
Autor:
Juan C Salazar, Fabio Vargas-Cely, Jonny A García-Luna, Lady G Ramirez, Everton B Bettin, Nelson Romero-Rosas, María F Amórtegui, Sebastián Silva, Oscar Oviedo, Julie Vigil, Carson J La Vake, Ximena Galindo, Jose D Ramirez, Alvaro J Martínez-Valencia, Melissa J Caimano, Christopher M Hennelly, Farhang Aghakhanian, M Anthony Moody, Arlene C Seña, Jonathan B Parr, Kelly L Hawley, Eduardo López-Medina, Justin D Radolf
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0307600 (2024)
BackgroundVenereal syphilis, caused by the spirochete Treponema pallidum subsp. pallidum (TPA), is surging worldwide, underscoring the need for a vaccine with global efficacy. Vaccine development requires an understanding of syphilis epidemiology and
Externí odkaz:
https://doaj.org/article/580798f8696f4cdb9290c1c44609ff3e
Autor:
André A Grassmann, Crispin Zavala-Alvarado, Everton B Bettin, Mathieu Picardeau, Nadia Benaroudj, Melissa J Caimano
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1009078 (2021)
Leptospira interrogans, the causative agent of most cases of human leptospirosis, must respond to myriad environmental signals during its free-living and pathogenic lifestyles. Previously, we compared L. interrogans cultivated in vitro and in vivo us
Externí odkaz:
https://doaj.org/article/b2104d6551464ea59aae5428c386c570
Autor:
Ashley M Groshong, André A Grassmann, Amit Luthra, Melissa A McLain, Anthony A Provatas, Justin D Radolf, Melissa J Caimano
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009725 (2021)
In this study, we examined the relationship between c-di-GMP and its only known effector protein, PlzA, in Borrelia burgdorferi during the arthropod and mammalian phases of the enzootic cycle. Using a B. burgdorferi strain expressing a plzA point mut
Externí odkaz:
https://doaj.org/article/ecf504a6e74e4a17837c52e966c55a6a
Autor:
Amit Luthra, Jairo M Montezuma-Rusca, Carson J La Vake, Morgan LeDoyt, Kristina N Delgado, Timothy C Davenport, Mary Fiel-Gan, Melissa J Caimano, Justin D Radolf, Kelly L Hawley
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008871 (2020)
Deconvolution of syphilis pathogenesis and selection of candidate syphilis vaccinogens requires detailed knowledge of the molecular architecture of the Treponema pallidum outer membrane (OM). The T. pallidum OM contains a low density of integral OM p
Externí odkaz:
https://doaj.org/article/9f2d3a5dcca444ddb23d923afab6a67f
Autor:
Melissa J Caimano, Sathesh K Sivasankaran, Anna Allard, Daniel Hurley, Karsten Hokamp, André A Grassmann, Jay C D Hinton, Jarlath E Nally
Publikováno v:
PLoS Pathogens, Vol 10, Iss 3, p e1004004 (2014)
Leptospirosis, an emerging zoonotic disease with worldwide distribution, is caused by spirochetes belonging to the genus Leptospira. More than 500,000 cases of severe leptospirosis are reported annually, with >10% of these being fatal. Leptospires ca
Externí odkaz:
https://doaj.org/article/c805b17089d740358987c91f52be1db4
Autor:
Kelly A Miller, Md A Motaleb, Jun Liu, Bo Hu, Melissa J Caimano, Michael R Miller, Nyles W Charon
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98338 (2014)
The spirochete periplasmic flagellum has many unique attributes. One unusual characteristic is the flagellar hook. This structure serves as a universal joint coupling rotation of the membrane-bound motor to the flagellar filament. The hook is compris
Externí odkaz:
https://doaj.org/article/5b148086342e494a9207cbc1e9b925b7
Autor:
Aydan Salman-Dilgimen, Pierre-Olivier Hardy, Justin D Radolf, Melissa J Caimano, George Chaconas
Publikováno v:
PLoS Pathogens, Vol 9, Iss 12, p e1003841 (2013)
The Lyme disease spirochete Borrelia burgdorferi must differentially express genes and proteins in order to survive in and transit between its tick vector and vertebrate reservoir. The putative DEAH-box RNA helicase, HrpA, has been recently identifie
Externí odkaz:
https://doaj.org/article/7497a13b55354b368ddbd33557fb7c82
Publikováno v:
PLoS Pathogens, Vol 8, Iss 2, p e1002532 (2012)
While the roles of rpoS(Bb) and RpoS-dependent genes have been studied extensively within the mammal, the contribution of the RpoS regulon to the tick-phase of the Borrelia burgdorferi enzootic cycle has not been examined. Herein, we demonstrate that
Externí odkaz:
https://doaj.org/article/b7639dce6513451c8ec07e609d1b9288
Autor:
Christopher J Pappas, Radha Iyer, Mary M Petzke, Melissa J Caimano, Justin D Radolf, Ira Schwartz
Publikováno v:
PLoS Pathogens, Vol 7, Iss 7, p e1002102 (2011)
Borrelia burgdorferi, the spirochetal agent of Lyme disease, is a vector-borne pathogen that cycles between a mammalian host and tick vector. This complex life cycle requires that the spirochete modulate its gene expression program to facilitate grow
Externí odkaz:
https://doaj.org/article/5ff93dc62a1e4cf5a9deab2570bd599c
Autor:
Haijun Xu, Melissa J Caimano, Tao Lin, Ming He, Justin D Radolf, Steven J Norris, Frank Gherardini, Alan J Wolfe, X Frank Yang
Publikováno v:
PLoS Pathogens, Vol 6, Iss 9, p e1001104 (2010)
Borrelia burgdorferi, the Lyme disease spirochete, dramatically alters its transcriptome and proteome as it cycles between the arthropod vector and mammalian host. During this enzootic cycle, a novel regulatory network, the Rrp2-RpoN-RpoS pathway (al
Externí odkaz:
https://doaj.org/article/3772354be86d40119bd3b3d0d3a343fc