Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Melissa J, Mulla"'
Publikováno v:
Reproduction. 159:73-80
Pre-gestational diabetes is a risk factor for preeclampsia, a condition associated with inflammatory markers, a dysregulated angiogenic profile, and impaired placentation. Using an in vitro model, we previously reported that hyperglycemic levels of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e2a7a782948a50591aa50bc88f965b
https://doi.org/10.1530/rep-19-0422
https://doi.org/10.1530/rep-19-0422
Autor:
Monica C. Pasternak, Lawrence W. Chamley, Vikki M. Abrahams, Melissa J. Mulla, Jane E. Salmon
Publikováno v:
Journal of Autoimmunity. 98:103-112
Women with antiphospholipid antibodies (aPL) are at high risk for pregnancy complications, such as preeclampsia. We previously demonstrated that aPL recognizing β2GPI promote an extravillous trophoblast pro-inflammatory, anti-migratory and anti-angi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0fb0222fdb5ad3d1e521838a21a2dd2
https://doi.org/10.1016/j.jaut.2018.12.003
https://doi.org/10.1016/j.jaut.2018.12.003
Autor:
Melissa J Mulla, Jane E Salmon, Larry W Chamley, Jan J Brosens, Crina M Boeras, Paula B Kavathas, Vikki M Abrahams
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65237 (2013)
Women with antiphospholipid syndrome (APS) are at risk of recurrent pregnancy loss and obstetrical disorders, such as preeclampsia and intrauterine growth restriction (IUGR). Antiphospholipid antibodies (aPL) directly target the placenta by binding b
Externí odkaz:
https://doaj.org/article/ca857426d47248a8a8af8868c6bb9425
Autor:
Melissa J. Mulla, Kathleen R. Heim, Seth Guller, Christina S. Han, Julie A. Potter, Vikki M. Abrahams
Publikováno v:
American journal of reproductive immunology (New York, N.Y. : 1989). 80(5)
Problem Hyperglycemia increases the risk of preeclampsia. Hyperglycemia induces a placental trophoblast inflammatory (IL-1β, IL-6, IL-8), antiangiogenic (sFlt-1, sEndoglin), and anti-migratory profile. The IL-1β response is mediated via inflammasom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dcc6dcc3c36284539ddffa3098d549b
https://pubmed.ncbi.nlm.nih.gov/30175447
https://pubmed.ncbi.nlm.nih.gov/30175447
Autor:
William W. Kwok, Andrew L. Goodman, Martin A. Kriegel, Silvio M. Vieira, Carina Dehner, Cassyanne L. Aguiar, Andrew T. Yu, Doruk Erkan, Vikki M. Abrahams, Odelya E. Pagovich, Christina Kriegel, Alexander S. Roth, Woo J. Kim, Ruth Nussinov, Melissa J. Mulla, William Ruff, Olamide Adeniyi
Publikováno v:
Cell hostmicrobe. 26(1)
Summary Given the immense antigenic load present in the microbiome, we hypothesized that microbiota mimotopes can be a persistent trigger in human autoimmunity via cross-reactivity. Using antiphospholipid syndrome (APS) as a model, we demonstrate cro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83d63b252586065feaf68df1f7384c8
https://pubmed.ncbi.nlm.nih.gov/31273334
https://pubmed.ncbi.nlm.nih.gov/31273334
Autor:
Luz P. Blanco, Mimi Y. Kim, Danieli Andrade, Mary K. Crow, Jane E. Salmon, Vikki M. Abrahams, Melissa J. Mulla, S. Ananth Karumanchi, Patricia Redecha, Angela M. Alvarez, Kyriakos A. Kirou, Mariana J. Kaplan, Gloria C. Koo
Publikováno v:
Arthritis & Rheumatology. 67:977-987
Systemic lupus erythematosus (SLE), the prototypic systemic autoimmune disease, predominantly afflicts women and presents during reproductive years. Pregnancy in patients with SLE is associated with increased risk for maternal and fetal morbidity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f830c9a34aa1efb1c57f98ecd9862d7e
https://doi.org/10.1002/art.39029
https://doi.org/10.1002/art.39029
Autor:
Lydia Luley, Anne Schumacher, Dirk Franke, Serban-Dan Costa, Berthold Hoppe, Melissa J. Mulla, Svetlana N. Tchaikovski, Ana Claudia Zenclussen, Sara Fill Malfertheiner, Vikki M. Abrahams, Michael Löttge
Publikováno v:
American Journal of Reproductive Immunology. 73:417-427
Problem Thrombophilia is associated with pregnancy complications. Treatment with low molecular weight heparin (LMWH) improves pregnancy outcome, but the underlying mechanisms are not clear. Methods of study We analyzed Treg frequency in blood from th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7016b61cc78296be8fd505581b9cb030
https://doi.org/10.1111/aji.12348
https://doi.org/10.1111/aji.12348
Autor:
Stefan Gysler, Lawrence W. Chamley, Jan J. Brosens, Vikki M. Abrahams, Michael J. Paidas, Anna K. Sfakianaki, Nancy L. Stanwood, Melissa J. Mulla, Meredith Stuhlman, Aileen M. Gariepy
Publikováno v:
American Journal of Reproductive Immunology. 73:242-250
Problem Women with antiphospholipid syndrome (APS) are at increased risk of recurrent pregnancy loss (RPL) and preeclampsia. Antiphospholipid antibodies (aPL) directly alter trophoblast function. Treatment with low molecular weight heparin (LMWH) red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d197df1e4852e08e045d39d257427657
https://doi.org/10.1111/aji.12301
https://doi.org/10.1111/aji.12301
Autor:
Errol R. Norwitz, Melissa J. Mulla, Serkalem Tadesse, Seth Guller, Kledia Myrtolli, Aileen M. Gariepy, Nancy L. Stanwood, Vikki M. Abrahams
Publikováno v:
American Journal of Reproductive Immunology. 69:449-453
Problem There is a strong correlation between intrauterine bacterial infection and preterm labor. While inflammation is a common mechanism, certain pathogens may trigger placental apoptosis. TLR2 activation by gram-positive bacterial peptidoglycan (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e043a58c18a826008deaa7fd32f188b1
https://doi.org/10.1111/aji.12065
https://doi.org/10.1111/aji.12065
Autor:
Marta M. Guerra, Jan J. Brosens, Jane E. Salmon, Melissa J. Mulla, Vikki M. Abrahams, Lawrence W. Chamley, Stefan Gysler
Study question What is the role of microRNAs (miRs) in antiphospholipid antibody (aPL)-induced trophoblast inflammation? Summary answer aPL-induced up-regulation of trophoblast miR-146a-3p is mediated by Toll-like receptor 4 (TLR4), and miR-146a-3p i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ecae32df8aa36baa51d66bbc837d72a
https://europepmc.org/articles/PMC4941806/
https://europepmc.org/articles/PMC4941806/
