Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Melissa J, Freeman"'
Autor:
Melissa J. Freeman
Publikováno v:
Qualitative Research in Medicine & Healthcare, Vol 3, Iss 3 (2019)
In the early morning hours of one night, when I am a neurology resident on call at the hospital, I am paged to a stroke alert. This means I had to run to the emergency room to see, assess, and treat a critically ill patient. (...)
Externí odkaz:
https://doaj.org/article/256f9d7111594ae292eb1aa317103acd
Autor:
Lisa M. Roth, Donna L. Herber, Nedda Wilson, Keisha Symmonds, Melissa J. Freeman, Marcia N. Gordon, Jessica L. Maloney, Dave Morgan, Mary Mercer
Publikováno v:
Journal of Neuroimmune Pharmacology. 2:222-231
Inflammation has been argued to play a fundamental role in the pathogenesis of Alzheimer's disease. Mice transgenic for mutant human amyloid precursor protein (APP) develop progressive amyloid deposition, gliosis, and cognitive impairment. Paradoxica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e15ea81a6f7e76f4b4d00faa492da7
https://doi.org/10.1007/s11481-007-9069-z
https://doi.org/10.1007/s11481-007-9069-z
Autor:
Sangeetha Subbarao, Arnon Rosenthal, Nedda Wilson, Jennifer Alamed, Donna M. Wilcock, David Wilson, Gil Levkowitz, Melissa J. Freeman, Amyn M. Rojiani, Dave Morgan, Marcia N. Gordon
Publikováno v:
The Journal of Neuroscience. 24:6144-6151
The role of microglia in the removal of amyloid deposits after systemically administered anti-Abeta antibodies remains unclear. In the current study, we injected Tg2576 APP transgenic mice weekly with an anti-Abeta antibody for 1, 2, or 3 months such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a3a983681b37edfb116d850818c77ad
https://doi.org/10.1523/jneurosci.1090-04.2004
https://doi.org/10.1523/jneurosci.1090-04.2004
Autor:
L. Michaels, Sonam Singh, Fiona Crawford, Andres M. Salazar, Laila Abdullah, Robert H. Lipsky, M. Waisman, Melissa J. Freeman, Rodney D. Vanderploeg, Deborah L. Warden, Michael Mullan
Publikováno v:
Neurology. 58:1115-1118
APOE has been demonstrated to influence traumatic brain injury (TBI) outcome. The relationship between APOE genotype and memory following TBI was examined in 110 participants in the Defense and Veterans' Head Injury Program. Memory performance was wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94628bb7974d864c81955c4387472d9
https://doi.org/10.1212/wnl.58.7.1115
https://doi.org/10.1212/wnl.58.7.1115
Publikováno v:
Neurology. 83(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bfb39b62f36afd94291a792679dcbcc7
https://pubmed.ncbi.nlm.nih.gov/25135913
https://pubmed.ncbi.nlm.nih.gov/25135913
Autor:
Ranjan Duara, Mark Morris, Fiona Crawford, Daniel P. Richards, Michael Mullan, Laila Abdullah, John A. Schinka, Melissa J. Freeman, Steven Sevush
Publikováno v:
Experimental Neurology. 167:456-459
A polymorphism in the Myeloperoxidase gene (MPO) has previously been demonstrated to be associated with gender-specific risk in an Alzheimer's Disease (AD) autopsy sample. We have investigated this polymorphism in our own samples of 226 Caucasian cas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3686b4b100af92fdb380f0d08bc04f2e
https://doi.org/10.1006/exnr.2000.7560
https://doi.org/10.1006/exnr.2000.7560
Autor:
Ranjan Duara, Laila Abdullah, John A. Schinka, Melissa J. Freeman, K. Krivian, Michael Mullan, Fiona Crawford, Ravi Anand, Mark Morris, Daniel P. Richards, Michael Gold, R. Hartman
Publikováno v:
Neurology. 55:763-768
Objective: To investigate whether or not a coding polymorphism in the cystatin C gene (CST3) contributes risk for AD.Design: A case-control genetic association study of a Caucasian dataset of 309 clinic- and community-based cases and 134 community-ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a14c0f7d553911bf4ca4812bd122782
https://doi.org/10.1212/wnl.55.6.763
https://doi.org/10.1212/wnl.55.6.763
Autor:
Steven Sevush, Ranjan Duara, Melissa J. Freeman, Fiona Crawford, Daniel P. Richards, Michael Mullan, Laila Abdullah, John A. Schinka
Publikováno v:
Neuroscience Letters. 289:61-65
The aspartyl protease Cathepsin D has previously been suggested to play a role in the Alzheimer's disease (AD) process because of its ability to cleave the beta-amyloid precursor protein and the possibility that it may be one of the 'secretase' enzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180bf93d996a58731a6534342672d265
https://doi.org/10.1016/s0304-3940(00)01260-x
https://doi.org/10.1016/s0304-3940(00)01260-x
Autor:
Melissa J. Freeman, Michael Gold, Ranjan Duara, Fiona Crawford, Terrence Town, Danielle Fallin, Michael Mullan
Publikováno v:
Neuroscience Letters. 266:193-196
Mutations in the tau protein gene have recently been found to cause familial fronto-temporal dementia in a number of kindreds demonstrating linkage to chromosome 17. Given that tau pathology is a hallmark of Alzheimer's disease (AD), this raises the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7dbe3970a7dbc4756bcfe285013004c
https://doi.org/10.1016/s0304-3940(99)00303-1
https://doi.org/10.1016/s0304-3940(99)00303-1
Autor:
Lisa M. Roth, Donna L. Herber, Dave Morgan, Marcia N. Gordon, Melissa J. Freeman, Jessica L. Maloney
Publikováno v:
Glia. 53(4)
Inflammation has been argued to play a primary role in the pathogenesis of Alzheimer's disease by contributing to the development of neuropathology and clinical symptoms. However, the mechanisms underlying these effects remain obscure. Lipopolysaccha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44f3a81f0767067f6c152356c11de2b
https://pubmed.ncbi.nlm.nih.gov/16288481
https://pubmed.ncbi.nlm.nih.gov/16288481