Data from Predicting IGF-1R Therapy Response in Bone Sarcomas: Immuno-SPECT Imaging with Radiolabeled R1507

Autor: Winette T.A. van der Graaf, Otto C. Boerman, Wim J.G. Oyen, Peter J. Houghton, Hanneke W.M. van Laarhoven, Melissa H.S. Roeffen, Sandra Heskamp, Janneke D.M. Molkenboer-Kuenen, Addy C.M. van de Luijtgaarden, Yvonne M.H. Versleijen-Jonkers, Emmy D.G. Fleuren

Purpose: To investigate whether indium-111–labeled R1507 (111In-R1507) immuno-SPECT (single—photon emission computed tomography), a novel noninvasive, in vivo screening method to visualize membranous insulin-like growth factor 1 receptor (IGF-1R)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e726d33c6025a0dd031b2332df37e72
https://doi.org/10.1158/1078-0432.c.6520857

Temsirolimus combined with cisplatin or bevacizumab is active in osteosarcoma models

Autor: Uta Flucke, Wim J.G. Oyen, Winette T. A. van der Graaf, Melissa H.S. Roeffen, Emmy D.G. Fleuren, Peter J. Houghton, Gerben M. Franssen, Yvonne M.H. Versleijen-Jonkers, Otto C. Boerman

Publikováno v: International Journal of Cancer. 135:2770-2782

Mammalian target of rapamycin (mTOR) is a new promising oncological target. However, most clinical studies reported only modest antitumor activity during mTOR-targeted monotherapies, including studies in osteosarcomas, emphasizing a need for improvem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5df1bc896269507b30ea287fe8bd16e9
https://doi.org/10.1002/ijc.28933

alphaB-crystallin expression is correlated with phospho-ERK1/2 expression in human breast cancer

Autor: Paul N. Span, Yvonne M.H. Versleijen-Jonkers, Hanneke W. M. van Laarhoven, Ger J. M. Pruijn, Melissa H.S. Roeffen, Fred C.G.J. Sweep, Chantal van de Schootbrugge, Johannes H.A.M. Kaanders, Johan Bussink, Wilbert C. Boelens, Freekje van Asten, Iris D. Nagtegaal

Publikováno v: International Journal of Biological Markers, 28, e365-70
International Journal of Biological Markers, 28, 4, pp. e365-70
International journal of biological markers, 28(4), e365-e370. Wichtig Publishing

Contains fulltext : 125273pub.pdf (Publisher’s version ) (Closed access) alphaB-crystallin is regarded as a biomarker for triple-negative and/or basal-like breast cancer. In normal breast cells, overexpression of alphaB-crystallin leads to neoplast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6352250fe1dc56e9aa7e4fcbb5897194
https://hdl.handle.net/2066/125273

Anaplastic Lymphoma Kinase Aberrations in Rhabdomyosarcoma: Clinical and Prognostic Implications

Autor: Winette T. A. van der Graaf, Eveline S. J. M. de Bont, Albert J. H. Suurmeijer, Melissa H.S. Roeffen, Yvonne M.H. Versleijen-Jonkers, Annelies M. C. Mavinkurve-Groothuis, J. Carlijn van Gaal, Uta Flucke, Stefan Sleijfer

Publikováno v: Journal of Clinical Oncology, 30(3), 308-315. American Society of Clinical Oncology
Journal of Clinical Oncology, 30, 3, pp. 308-15
Journal of Clinical Oncology, 30, 308-15
Journal of Clinical Oncology, 30(3), 308-315. AMER SOC CLINICAL ONCOLOGY

Purpose The aim of this study is to investigate anaplastic lymphoma kinase (ALK) protein expression and underlying genetic aberrations in rhabdomyosarcoma (RMS), with special attention to clinical and prognostic implications. Patients and Methods A t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73514b0afdc4d46e5407b636c82d4d50
https://pure.eur.nl/en/publications/c7c23a52-46b1-4165-80cc-767bf69478a0

The strength of small: Improved targeting of Insulin-like Growth Factor-1 Receptor (IGF-1R) with F(ab')2-R1507 fragments in Ewing sarcomas

Autor: Melissa H.S. Roeffen, Hanneke W. M. van Laarhoven, Winette T. A. van der Graaf, Sandra Heskamp, Yvonne M.H. Versleijen-Jonkers, Otto C. Boerman, Wim J.G. Oyen, Emmy D.G. Fleuren, Wilbert H. Bouwman, Janneke D.M. Molkenboer-Kuenen

Publikováno v: European Journal of Cancer, 49, 13, pp. 2851-8
European Journal of Cancer, 49, 2851-8
European journal of cancer (Oxford, England, 49(13), 2851-2858. Elsevier Limited

Item does not contain fulltext PURPOSE: To investigate whether F(ab')2-fragments of the monoclonal Insulin-like Growth Factor-1 Receptor (IGF-1R) antibody R1507 (F(ab')2-R1507) can successfully target IGF-1R in Ewing sarcomas (ES). MATERIALS AND METH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16cd3f3077b6aa8db00998a36b53443
https://doi.org/10.1016/j.ejca.2013.04.009