Výsledky vyhledávání - "Melissa H. Vos"

(R)-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) Blocks Polymodal Activation of Transient Receptor Potential Vanilloid 1 Receptors in Vitro and Heat-Evoked Firing of Spinal Dorsal Horn Neurons in Vivo

Autor: Carol S. Surowy, Katharine L. Chu, Prisca Honore, Rachid El Kouhen, Connie R. Faltynek, Bruce R. Bianchi, Ping Han, James P. Sullivan, Steve McGaraughty, Wende Niforatos, Arthur Gomtsyan, Erol K. Bayburt, Chih-Hung Lee, Torben R. Neelands, Heath A. McDonald, Melissa H. Vos, Michael F. Jarvis

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 326:879-888

The transient receptor potential vanilloid (TRPV) 1 receptor, a nonselective cation channel expressed on peripheral sensory neurons and in the central nervous system, plays a key role in pain. TRPV1 receptor antagonism is a promising approach for pai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d345e34dd8700b32db5ac00c4d0fbd47
https://doi.org/10.1124/jpet.108.138511

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Quantification of TRPV1 protein levels in rat tissues to understand its physiological roles

Autor: Ping Han, Mark L. Chiu, Melissa H. Vos, Connie R. Faltynek, Robert B. Moreland, Alla V. Korepanova

Publikováno v: Journal of molecular neuroscience : MN. 50(1)

Transient receptor potential subfamily V, member 1 (TRPV1) is a nonselective cation channel expressed in both the peripheral and central nervous systems (CNS). TRPV1 protein levels in rat tissues were determined under normal and pain states using enz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a79bfb43ce808441df455f3c1e9c3a4
https://pubmed.ncbi.nlm.nih.gov/22798269

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Development of ELISA to measure TRPV1 protein in rat tissues

Autor: Robert B. Moreland, Alla Korepanova, Connie R. Faltynek, Marc R. Lake, Ana Pereda-Lopez, Bruce R. Bianchi, Ping Han, Melissa H. Vos, Mark L. Chiu

Publikováno v: Journal of neuroscience methods. 200(2)

The transient receptor potential vanilloid receptor type 1 (TRPV1) is a non-selective cation channel expressed in both the peripheral and the central nervous systems. To quantitatively determine TRPV1 protein levels in native rat tissues, novel monoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b56681e0c4d2aa334cd53e05135c966c
https://pubmed.ncbi.nlm.nih.gov/21762727

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Characterization of A-425619 at native TRPV1 receptors: a comparison between dorsal root ganglia and trigeminal ganglia

Autor: Heath A. McDonald, Pamela S. Puttfarcken, Ping Han, Michael E. Kort, Connie R. Faltynek, Melissa H. Vos, Torben R. Neelands, Robert B. Moreland

Publikováno v: European journal of pharmacology. 596(1-3)

1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea (A-425619), a novel, potent, and selective transient receptor potential type V1 (TRPV1) antagonist, attenuates pain associated with inflammation and tissue injury in rats. The purpose of this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e402381c5ed29a9f2116727508a845fb
https://pubmed.ncbi.nlm.nih.gov/18755179

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Capsaicin causes protein synthesis inhibition and microtubule disassembly through TRPV1 activities both on the plasma membrane and intracellular membranes

Autor: Robert B. Moreland, Connie R. Faltynek, Rachid El Kouhen, Ping Han, Heath A. McDonald, Michael F. Jarvis, Melissa H. Vos, Bruce R. Bianchi

Publikováno v: Biochemical pharmacology. 73(10)

TRPV1 is a non-selective cationic channel that is activated by capsaicin, acidic pH and thermal stimuli. Sustained TRPV1 channel activation causes severe cytotoxicity that leads to cell death. In this study, we investigated the mechanisms of capsaici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd43aca4a186434267241c8e0bde7a8
https://pubmed.ncbi.nlm.nih.gov/17274957

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TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells

Autor: Robert B. Moreland, Ping Han, Paul E. Kroeger, Connie R. Faltynek, Heath A. McDonald, Melissa H. Vos, Won Choi, Pamela S. Puttfarcken, Torben R. Neelands

Publikováno v: Journal of neurochemistry. 99(4)

Transient receptor potential channel type V (TRPV) 1 is a non-selective cation channel that can be activated by capsaicin, endogenous vanilloids, heat and protons. The human TRPV1 splice variant, TRPV1b, lacking exon 7, was cloned from human dorsal r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5875c6d2338fece64c0eb575784896
https://pubmed.ncbi.nlm.nih.gov/17018028

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A high throughput fluorescent assay for measuring the activity of fatty acid amide hydrolase

Autor: Paul L. Richardson, Usha Warrior, Jean M. Severin, Carol S. Surowy, Victoria E. Scott, Ana Pereda-Lopez, Connie R. Faltynek, Melissa H. Vos, Thomas H. Lubben, Larry R. Solomon, Karen Kage, Karl A. Walter, Linda Traphagen, Diane Bartley, Rachel Davis-Taber, John E. Harlan, Thomas F. Holzman

Publikováno v: Journal of neuroscience methods. 161(1)

Fatty acid amide hydrolase (FAAH) is the enzyme responsible for the rapid degradation of fatty acid amides such as the endocannabinoid anandamide. Inhibition of FAAH activity has been suggested as a therapeutic approach for the treatment of chronic p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240a130c2aa5cc1fcc48ea87f14e2503
https://pubmed.ncbi.nlm.nih.gov/17083980

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