Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Melissa H. Costell"'
Autor:
Shailesh Bihari, Melissa H. Costell, Tara Bouchier, David J. Behm, Mark Burgert, Guosen Ye, Andrew D. Bersten, Stephanie Puukila, Elena Cavallaro, Dennis L. Sprecher, Dani-Louise Dixon
Publikováno v:
SSRN Electronic Journal.
Autor:
Joseph E. Pero, Dennis A. Holt, Carl Brooks, Matthews Jay M, Melissa H. Costell, Raynold Shenje, John J. McAtee, David J. Behm, Ralph A. Rivero, Larry J. Jolivette, Sanchez Robert, Brent W. Mccleland, Lamont Roscoe Terrell, Jaclyn R. Patterson, Edward J. Brnardic, Theresa J. Roethke, Brian G. Lawhorn, Linda S. Barton
Publikováno v:
Journal of Medicinal Chemistry. 62:9270-9280
GSK3527497, a preclinical candidate for the inhibition of TRPV4, was identified starting from the previously reported pyrrolidine sulfonamide TRPV4 inhibitors 1 and 2. Optimization of projected human dose was accomplished by specifically focusing on
Autor:
Kevin S. Thorneloe, Theresa J. Roethke, Krista B. Goodman, Jaclyn R. Patterson, Dennis L. Sprecher, Navin Goyal, Melissa H. Costell, David J. Behm, Christian H. James, Patrick Stoy, Xiaoping Xu
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 376(3)
Transient receptor potential vanilloid 4 (TRPV4) channels expressed on pulmonary endothelial cells are activated by elevated pulmonary vascular pressure, resulting in endothelial shape change, pulmonary barrier disruption, and edema. As such, TRPV4 b
Autor:
Melissa H Costell, Nicolas eAncellin, Roberta E Bernard, Shufang eZhao, John J Upson, Lisa A Morgan, Kristeen eHauk, Alan R Olzinski, Victoria L T Ballard, Kenny eHerry, Pascal eGrondin, Nerina eDodic, Olivier eMirguet, Anne eBouillot, Francoise eGellibert, Robert W Coatney, John J Lepore, Beat M. Jucker, Larry J Jolivette, Robert N Willette, Christine G Schnackenberg, David J Behm
Publikováno v:
Frontiers in Pharmacology, Vol 3 (2012)
Soluble guanylate cyclase (sGC), the primary mediator of nitric oxide (NO) bioactivity, exists as reduced (NO-sensitive) and oxidized (NO-insensitive) forms. We tested the hypothesis that the cardiovascular protective effects of NO-insensitive sGC ac
Externí odkaz:
https://doaj.org/article/7de0d838ef7f45aba69ae237f3a44947
Autor:
Boyi Liu, Michael D. Gunn, M.E. Burgert, Michael A Gentile, Ana Isabel Caceres, D.J. Behm, Sven-Eric Jordt, Ira M. Cheifetz, Melissa H. Costell, Satyanarayana Achanta
Publikováno v:
A16. CHEMICAL THREATS AND INJURY: MECHANISMS AND TREATMENT.
Autor:
Brian G. Lawhorn, Brian Budzik, Karl F. Erhard, Huijie Li, Carla A. Donatelli, Kalindi Vaidya, Melissa H. Costell, Joseph E. Pero, John J. McAtee, Carl Brooks, Lorraine M. Posobiec, Larry J. Jolivette, Dennis A. Holt, Theresa J. Roethke, Stephen H. Eisennagel, Michael C. Fischer, Matthews Jay M, Arthur Shu, Brent W. Mccleland, Lamont Roscoe Terrell, Sender Matthew Robert, Katrina Rivera, David J. Behm, Israil Pendrak, Ralph A. Rivero, Xiaoping Xu, Edward J. Brnardic, Peng Li
Publikováno v:
Journal of medicinal chemistry. 61(24)
Pulmonary edema is a common ailment of heart failure patients and has remained an unmet medical need due to dose-limiting side effects associated with current treatments. Preclinical studies in rodents have suggested that inhibition of transient rece
Autor:
Arthur Shu, Carla A. Donatelli, Sanchez Robert, Melissa H. Costell, Carl Brooks, Yanan He, Jeff J. McAtee, David J. Behm, Guosen Ye, Dennis A. Holt, Theresa J. Roethke, Brian G. Lawhorn, Grazyna Graczyk-Millbrandt, Lamont Roscoe Terrell, Edward J. Brnardic, Patrick Stoy, Linda S. Barton, Karl F. Erhard
Publikováno v:
Journal of medicinal chemistry. 61(21)
A novel series of pyrrolidine sulfonamide transient receptor potential vanilloid-4 (TRPV4) antagonists was developed by modification of a previously reported TRPV4 inhibitor (1). Several core-structure modifications were identified that improved TRPV
Autor:
Yun Ding, Lisa M. Shewchuk, Martin Brandt, Ami L. Shaw, David I. Israel, Stephen A. Douglas, Gregory D. Brown, Dennis A. Holt, Christine G. Schnackenberg, Rusty E. Fries, Jeffrey W. Gross, Larry J. Jolivette, Tracy Mandichak, Jason W. Dodson, Melissa H. Costell, Mark R. Harpel, Steve H. Eisennagel, Jeff J. McAtee, Theresa J. Roethke, Reema K. Thalji, Svetlana L. Belyanskaya, Hu Li, Wensheng Xie, Joseph P. Marino, Quinn Lu, Benjamin Schwartz, David J. Behm, Daniel J. Krosky
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3584-3588
1-(1,3,5-Triazin-yl)piperidine-4-carboxamide inhibitors of soluble epoxide hydrolase were identified from high through-put screening using encoded library technology. The triazine heterocycle proved to be a critical functional group, essential for hi
Autor:
Alan R. Olzinski, Stephen A. Douglas, Marianne E. Eybye, Melissa H. Costell, Stephen A. Smith, Susan M. Gruver, Colin H. Macphee, Douglas G. Johns, Zhaohui Ao
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 315:1020-1027
Increased susceptibility to atherosclerosis increases the risk of mortality in type 2 diabetic patients. Leukocyte adhesion to the endothelium is a critical step in atherogenesis. In addition to its insulin-sensitizing effects, rosiglitazone (RSG) po
Autor:
James Tunstead, Robert N. Willette, Linda N. Casillas, Mui Cheung, Guosen Ye, Ming-Yuan Jian, Hasan Alsaid, John J. Lepore, Earl Gordon, John R. Toomey, Daniel S Matasic, Kristeen Maniscalco-Hauk, Chris James, J. Larkin, Kevin S. Thorneloe, Eidam Hilary Schenck, Stephen C. Lenhard, Krista B. Goodman, Lorena A. Kallal, Brian Donovan, Alan R. Olzinski, Pu Qin, Mary I. Townsley, Christine G. Schnackenberg, Lou Elefante, Weike Bao, John A. Krawiec, Theresa J. Roethke, Irina M. Lozinskaya, Kalindi Vaidya, Elizabeth A. Davenport, Melissa H. Costell, Robert W. Marquis, Beat M. Jucker, Mark E. Burgert, Anna Waszkiewicz
Publikováno v:
Science Translational Medicine. 4
Pulmonary edema resulting from high pulmonary venous pressure (PVP) is a major cause of morbidity and mortality in heart failure (HF) patients, but current treatment options demonstrate substantial limitations. Recent evidence from rodent lungs sugge