Protocol for detection of glial complement expression in relation to amyloid plaques in mouse brain with combined FISH and IHC

Autor: Sadhna Rao, Joanna Yung, Melissa Gonzalez Edick, Jesse E. Hanson

Publikováno v: STAR Protocols, Vol 5, Iss 4, Pp 103388- (2024)

Summary: Complement proteins contribute to neurodegeneration in Alzheimer’s disease (AD) and are secreted by glia surrounding beta-amyloid (Aβ) plaques. We present an optimized protocol for Aβ plaque detection with tyramide-digoxigenin signal amp

Externí odkaz: https://doaj.org/article/c7f93bd908ec4ded9cd688f37fdd63a8

Data from CBP/p300 Drives the Differentiation of Regulatory T Cells through Transcriptional and Non-Transcriptional Mechanisms

Autor: Zineb Mounir, Mark R. Lackner, Jennifer M. Giltnane, Vicki Plaks, Shih-Min A. Huang, Steven Magnuson, F. Anthony Romero, Andrew Glibicky, Thomas Holcomb, Somayeh S. Tarighat, Matthew P. Stokes, Wendell Jones, Katherine E. Hutchinson, Bonnie Liu, Jeffrey Eastham-Anderson, Melissa Gonzalez Edick, Sangeeta Jayakar, Marie-Claire Wagle, Ron McCord, Shrividhya Srinivasan, Christopher Lowe, Esther Wu, Joseph Castillo

Regulatory T cells (Treg) are immunosuppressive and negatively impact response to cancer immunotherapies. CREB-binding protein (CBP) and p300 are closely related acetyltransferases and transcriptional coactivators. Here, we evaluate the mechanisms by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00dfda38464bfe249a1e9c6500c6cdae
https://doi.org/10.1158/0008-5472.c.6510854.v1

Supplementary Figure Legend from Relaxin-Expressing, Fiber Chimeric Oncolytic Adenovirus Prolongs Survival of Tumor-Bearing Mice

Autor: Karin Jooss, Chae-Ok Yun, Michael Robinson, Melinda VanRoey, Marina Abramova, Neeraja Idamakanti, Melissa Gonzalez Edick, Shanthi Ganesh

Supplementary Figure Legend from Relaxin-Expressing, Fiber Chimeric Oncolytic Adenovirus Prolongs Survival of Tumor-Bearing Mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b9efb83ff20a10fd88015e2f859d68
https://doi.org/10.1158/0008-5472.22370522

A randomized, placebo‐controlled trial evaluating effects of lebrikizumab on airway eosinophilic inflammation and remodelling in uncontrolled asthma (CLAVIER)

Autor: Kathryn Mesh, Kun Peng, John G. Matthews, Prescott G. Woodruff, Wendy S. Putnam, Melissa Gonzalez Edick, Elliot Israel, Peter Bradding, Margaret Solon, Francis Abreu, Arnaud Bourdin, Kit Wong, Monet Howard, Monica Kraft, Cecile T.J. Holweg, Joseph R. Arron, Cary D. Austin, J. Mark FitzGerald, Gail M. Gauvreau, David F. Choy, Fang Cai, Ronald E. Ferrando, Lief Bjermer, Miriam Baca, Julie Olsson, Clavier Investigators, Kaharu Sumino

Publikováno v: Clinical and Experimental Allergy
Clinical and Experimental Allergy, Wiley, In press, ⟨10.1111/cea.13731⟩
Clinical and Experimental Allergy, In press, ⟨10.1111/cea.13731⟩

Background The anti-interleukin 13 (IL-13) monoclonal antibody lebrikizumab improves lung function in patients with moderate-to-severe uncontrolled asthma, but its effects on airway inflammation and remodelling are unknown. CLAVIER was designed to as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e09f921ff0a596f26f42c8645f7cfe
http://europepmc.org/articles/PMC7756263

Antibody responses to galectin-8, TARP and TRAP1 in prostate cancer patients treated with a GM-CSF-secreting cellular immunotherapy

Autor: Melissa Gonzalez-Edick, Minh C. Nguyen, Kathryn E. Koprivnikar, Guang Huan Tu, Karin Jooss, Thomas Harding

Publikováno v: Cancer Immunology, Immunotherapy. 59:1313-1323

A critical factor in clinical development of cancer immunotherapies is the identification of tumor-associated antigens that may be related to immunotherapy potency. In this study, protein microarrays containing >8,000 human proteins were screened wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c39107d0bea1060d6ca40c728c0fdb0
https://doi.org/10.1007/s00262-010-0858-5