Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Melissa Geddie"'
Autor:
Lia Luus, Vasileios Askoxylakis, John Wilton, Alexey Lugovskoy, Kenneth J. Olivier, Stephanie Grabow, Jaeyeon Kim, Christine Pien, Geoffrey Kuesters, Suresh K. Tipparaju, Melissa Geddie, Nancy Dumont, Mark E. Hayes, Alexander Koshkaryev, Sarah A Schihl, C. Patrick Reynolds, Rachel Blaydes, Andrew J. Sawyer, James D. Marks, Tad Kornaga, James Suchy, Charles O. Noble, Dmitri B. Kirpotin, Shinji Oyama, Neeraj Kohli, Zhaohua Richard Huang, Walid S. Kamoun, Daryl C. Drummond, Yu Zhou
Publikováno v:
Nature Biomedical Engineering. 3:264-280
Antibody-mediated tumour targeting and nanoparticle-mediated encapsulation can reduce the toxicity of antitumour drugs and improve their efficacy. Here, we describe the performance of a nanotherapeutic encapsulating a hydrolytically sensitive docetax
Autor:
Ashish Kalra, Jeffrey D. Kearns, Adnan O. Abu-Yousif, Gavin MacBeath, Alexey Lugovskoy, Maria Håkansson, Derek T. Logan, Birgit Schoeberl, Martin Welin, Melissa Geddie, Ulrik B. Nielsen, Neeraj Kohli, Tim Maiwald, Jessica B. Casaletto, Aaron Fulgham, Brian Harms, Shrikanta Chattopadhyay, Stephen Su, Maja Razlog, Antoine Boudot, Kristina Masson, Andreas Raue
Publikováno v:
Proceedings of the National Academy of Sciences. 116:7533-7542
Activation of the Met receptor tyrosine kinase, either by its ligand, hepatocyte growth factor (HGF), or via ligand-independent mechanisms, such as MET amplification or receptor overexpression, has been implicated in driving tumor proliferation, meta
Autor:
Ulrik B. Nielsen, Lihui Xu, Kathy Zhang, Daryl C. Drummond, Tad Kornaga, Alexey Lugovskoy, Neeraj Kohli, Yang Jiao, Melissa Geddie, Dmitri B. Kirpotin, Rachel Rennard
Publikováno v:
mAbs. 7:42-52
Antibody-targeted nanoparticles have the potential to significantly increase the therapeutic index of cytotoxic anti-cancer therapies by directing them to tumor cells. Using antibodies or their fragments requires careful engineering because multiple
Autor:
Melissa Geddie, Neeraj Kohli
Publikováno v:
Methods in Molecular Biology ISBN: 9781493968558
The discovery of antibodies that bind to targets with high affinity is now a routine exercise. However, it is still challenging to screen for candidates that, in addition to having excellent biological properties, also have optimal biophysical charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb9c02056a0f108cc2bda552e00981fd
https://doi.org/10.1007/978-1-4939-6857-2_11
https://doi.org/10.1007/978-1-4939-6857-2_11
Autor:
Alexey Lugovskoy, Rachel Rennard, Dmitri B. Kirpotin, Melissa Geddie, Tad Kornaga, Birgit Schoerberl, James D. Marks, Maja Razlog, Lihui Xu, Neeraj Kohli, Yang Jiao, Daryl C. Drummond
Publikováno v:
mAbs, vol 9, iss 1
Antibody-targeted nanoparticles have great promise as anti-cancer drugs; however, substantial developmental challenges of antibody modules prevent many candidates from reaching the clinic. Here, we describe a robust strategy for developing an EphA2-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa91df438843b3da3c3a9876275130f
https://escholarship.org/uc/item/1z81p181
https://escholarship.org/uc/item/1z81p181
Autor:
Esti Yeger-Lotem, David R. Karger, Pavan K. Auluck, Oliver D. King, Ernest Fraenkel, Melissa Geddie, Linhui Julie Su, Aaron D. Gitler, Susan Lindquist, Julie S. Valastyan, Laura Riva, Anil G. Cashikar
Publikováno v:
Nature Genetics. 41:316-323
Cells respond to stimuli by changes in various processes, including signaling pathways and gene expression. Efforts to identify components of these responses increasingly depend on mRNA profiling and genetic library screens, yet the functional roles
Monoclonal antibodies and antibody-like molecules represent a fast-growing class of bio-therapeutics that has rapidly transformed patient care in a variety of disease indications. The discovery of antibodies that bind to particular targets with high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ccec6aa47092bbe769782550c095bf
https://europepmc.org/articles/PMC4622974/
https://europepmc.org/articles/PMC4622974/
Autor:
Melissa Geddie, Alexey Lugovskoy
Publikováno v:
Biobetters ISBN: 9781493925421
Antibody therapeutics is a thriving field with currently over thirty treatments that are approved primarily for oncology and inflammatory disorders. Antibodies have many advantages as drugs, including high specificity to their targets, long half-live
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c31e532102fdb5bd1e3f0a75b13bb7f
https://doi.org/10.1007/978-1-4939-2543-8_12
https://doi.org/10.1007/978-1-4939-2543-8_12
Autor:
Neeraj Kohli, Dake Tamara, Haluk Yuzugullu, Violette Paragas, Lihui Xu, Greg Finn, Yasmin Hashambhoy-Ramsay, Maja Razlog, Birgit Schoeberl, Charlotte Mcdonagh, Melissa Geddie, Sara Ghassemifar, Marco Muda
Publikováno v:
Cancer Research. 77:22-22
Aberrant signaling of the FGFR pathway has long been known to promote tumorigenesis and angiogenesis across multiple cancer indications. However, the development of an effective and well-tolerated FGFR targeted inhibitor has been hindered by the need
Autor:
Dmitri B. Kirpotin, Lia Luus, Walid S. Kamoun, Tad Kornaga, Daryl C. Drummond, James D. Marks, Alexey Lugovskoy, Minh T. Pham, Lihui Xu, Shinji Oyama, Carl Morrisson, Theresa Feng, Melissa Geddie, Monica L. Murphy
Publikováno v:
Cancer Research. 76:750-750
Ephrin receptor A2 (EphA2) is part of the Ephrin family of cell-cell junction proteins highly overexpressed in several solid tumors, and is associated with poor prognosis. We developed a novel EphA2-targeted docetaxel nanoliposome, leveraging organ s