Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Melissa G. Grim"'
Presenilin-1 differentially facilitates endoproteolysis of the β-amyloid precursor protein and Notch
Autor:
Melissa G. Grim, Ralf Baumeister, Miriam Baader, Christian Haass, Harald Steiner, Anja Capell, Helmut Romig, Simone Keck
Publikováno v:
Nature Cell Biology. 2:205-211
Mutations in the presenilin-1 (PS1) gene are associated with Alzheimer's disease and cause increased secretion of the neurotoxic amyloid-beta peptide (Abeta). Critical intramembraneous aspartates at residues 257 and 385 are required for the function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e29c6a4bc93474f0c45bd73db1c841
https://doi.org/10.1038/35008626
https://doi.org/10.1038/35008626
Autor:
Harald Steiner, Manuela Neumann, Henry Houlden, Melissa G. Grim, Janice L. Holton, Brigitte Pesold, Hans A. Kretzschmar, Christian Haass, Ralf Baumeister, Tamas Revesz, Helmut Romig, John Hardy
Publikováno v:
The Journal of biological chemistry. 276(10)
Familial Alzheimer's disease (FAD) is frequently associated with mutations in the presenilin-1 (PS1) gene. Almost all PS1-associated FAD mutations reported so far are exchanges of single conserved amino acids and cause the increased production of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd833c578c83b28032e7ea8f9fde02f
https://pubmed.ncbi.nlm.nih.gov/11084029
https://pubmed.ncbi.nlm.nih.gov/11084029
Autor:
Hansruedi Loetscher, Helmut Jacobsen, Ralf Baumeister, Christine Kocyba, Dieter P. Reinhardt, Hanspeter Kurt, Melissa G. Grim, Daniel Bur, Manfred Brockhaus
Publikováno v:
The Journal of biological chemistry. 274(49)
Mutant presenilins (PS) contribute to the pathogenesis of familial Alzheimer's disease (FAD) by enhancing the production of Abeta42 from beta-amyloid precursor protein. Presenilins are endoproteolytically processed to N-terminal and C-terminal fragme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955a8ccc0d0544e4f4b7856e46a4246f
https://pubmed.ncbi.nlm.nih.gov/10575009
https://pubmed.ncbi.nlm.nih.gov/10575009
Autor:
Ralf Baumeister, Christian Haass, Uwe Philipp, Melissa G. Grim, Helmut Romig, Martin Citron, Brigitte Pesold, Harald Steiner
Publikováno v:
The Journal of biological chemistry. 274(12)
The two homologous presenilins are key factors for the generation of amyloid beta-peptide (Abeta), since Alzheimer's disease (AD)-associated mutations enhance the production of the pathologically relevant 42-amino acid Abeta (Abeta42), and a gene kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8939dc0a84ac6abf46c8e7138b101ca
https://pubmed.ncbi.nlm.nih.gov/10075646
https://pubmed.ncbi.nlm.nih.gov/10075646
Autor:
Christian Haass, Melissa G. Grim, Ralf Baumeister, Helmat Romig, Harold Steiner, Miriam Baader, John Hardy
Publikováno v:
Neurobiology of Aging. 21:67
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90907b9e08b81360e3a937a3f3541cae
https://doi.org/10.1016/s0197-4580(00)82525-7
https://doi.org/10.1016/s0197-4580(00)82525-7