Population-Level Portal-Based Anxiety and Depression Screening Perspectives in HIV Care Clinicians: Qualitative Study Using the Consolidated Framework for Implementation Research

Autor: Daniela Zimmer, Erin M Staab, Jessica P Ridgway, Jessica Schmitt, Melissa Franco, Scott J Hunter, Darnell Motley, Neda Laiteerapong

Publikováno v: JMIR Formative Research, Vol 8, p e48935 (2024)

BackgroundDepression and anxiety are common among people with HIV and are associated with inadequate viral suppression, disease progression, and increased mortality. However, depression and anxiety are underdiagnosed and undertreated in people with H

Externí odkaz: https://doaj.org/article/e6ca32d6dfcc42ed9767412a911783c6

Going beyond the individual: how state-level characteristics relate to HPV vaccine rates in the United States

Autor: Melissa Franco, Stephanie Mazzucca, Margaret Padek, Ross C. Brownson

Publikováno v: BMC Public Health, Vol 19, Iss 1, Pp 1-9 (2019)

Abstract Background The human papillomavirus (HPV) vaccine is an underutilized cancer control practice in the United States. Although individual contextual factors are known to impact HPV vaccine coverage rates, the impact of macro-level elements are

Externí odkaz: https://doaj.org/article/7fc736d620694b589095dd794a2a8698

Dynamics of the most common pathogenic mtDNA variant m.3243A > G demonstrate frequency-dependency in blood and positive selection in the germline

Autor: Konstantin Khrapko, Zoe Fleischmann, Maxim Braverman, Markuzon N, Jonathan L. Tilly, Douglass M. Turnbull, Sarah J Pickett, David Stein, Dori C. Woods, Konstantin Popadin, Mark Khrapko, D. Aidlen, Melissa Franco

Publikováno v: Human Molecular Genetics. 31:4075-4086

The A-to-G point mutation at position 3243 in the human mitochondrial genome (m.3243A > G) is the most common pathogenic mtDNA variant responsible for disease in humans. It is widely accepted that m.3243A > G levels decrease in blood with age, and an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a839a2f5c569df08360250b0e656a392
https://doi.org/10.1093/hmg/ddac149

The ‘Stem’ and the ‘Workers’ of the mtDNA population of the cell. Evidence from mutational analysis

Autor: Auden Cote-L’Heureu, Melissa Franco, Yogesh N. K. Maithania, Konstantin Popadin, Dori Woods, Jonathan Tilly, Konstantin Khrapko

Every cell in our body contains a vibrant population of mitochondria, or, more precisely, of mitochondrial DNA molecules (mtDNAs). Just like members of any population mtDNAs multiply (by replication) and ‘die’ (i.e., are removed, either by degrad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1495144bf983fd14e0b60ade1e1f0bf7
https://doi.org/10.1101/2023.04.14.536897

A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand

Autor: Alina G Mikhailova, Alina A Mikhailova, Kristina Ushakova, Evgeny O Tretiakov, Dmitrii Iliushchenko, Victor Shamansky, Valeria Lobanova, Ivan Kozenkov, Bogdan Efimenko, Andrey A Yurchenko, Elena Kozenkova, Evgeny M Zdobnov, Vsevolod Makeev, Valerian Yurov, Masashi Tanaka, Irina Gostimskaya, Zoe Fleischmann, Sofia Annis, Melissa Franco, Kevin Wasko, Stepan Denisov, Wolfram S Kunz, Dmitry Knorre, Ilya Mazunin, Sergey Nikolaev, Jacques Fellay, Alexandre Reymond, Konstantin Khrapko, Konstantin Gunbin, Konstantin Popadin

Publikováno v: Denisov, S 2022, ' A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand ', Nucleic acids research, vol. 50, pp. 10264–10277 . https://doi.org/10.1093/nar/gkac779

The mutational spectrum of the mitochondrial DNA (mtDNA) does not resemble any of the known mutational signatures of the nuclear genome and variation in mtDNA mutational spectra between different organisms is still incomprehensible. Since mitochondri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aaf04f68180d9afc181527a26230b3c
https://doi.org/10.1093/nar/gkac779