Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Melissa Feitosa"'
Autor:
Woori Kim, Mohit Tripathi, Chunhyung Kim, Satyapavan Vardhineni, Young Cha, Shamseer Kulangara Kandi, Melissa Feitosa, Rohit Kholiya, Eric Sah, Anuj Thakur, Yehan Kim, Sanghyeok Ko, Kaiya Bhatia, Sunny Manohar, Young-Bin Kong, Gagandeep Sindhu, Yoon-Seong Kim, Bruce Cohen, Diwan S. Rawat, Kwang-Soo Kim
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The nuclear receptor, Nurr1, is critical for both the development and maintenance of midbrain dopamine neurons, representing a promising molecular target for Parkinson’s disease (PD). We previously identified three Nurr1 agonists (amodiaqu
Externí odkaz:
https://doaj.org/article/b81b0d3dcdc14cc4b8e8e7f126ca1dbb
Autor:
Bin Song, Jacob W. Feldmann, Shibo Cao, Melissa Feitosa, Youngbin Kong, Woori Kim, Altana Schweitzer, Pierre Leblanc, Jeffrey S. Schweitzer, Kwang-Soo Kim
Publikováno v:
Neurobiology of Disease, Vol 170, Iss , Pp 105777- (2022)
Parkinson's disease (PD) is characterized by the selective death of substantia nigra pars compacta (SNpc) dopaminergic neurons and includes both motor and non-motor symptoms. While numerous models exist for the study of typical PD motor deficits, few
Externí odkaz:
https://doaj.org/article/c9f38490aafa408b85272d64db13705c
Autor:
Jeha Jeon, Bruce M. Cohen, Maria Jose Luna, Vadim Y. Bolshakov, Jeffrey Schweitzer, Hyemyung Seo, Kwang Soo Kim, Jin Hyuk Jung, Jisun Kim, Jeffrey H. Kordower, Claudia Lopes, Melissa Feitosa, Pierre Leblanc, Kyungjoon Park, Dabin Hwang, Young Joo Cha, Martin H. Teicher, Sek Won Kong, In-Hee Lee, Sanghyeok Ko, Bob S. Carter, Bin Song, Nayeon Lee
Publikováno v:
J Clin Invest
Parkinson's disease (PD) is a neurodegenerative disorder associated with loss of striatal dopamine, secondary to degeneration of midbrain dopamine (mDA) neurons in the substantia nigra, rendering cell transplantation a promising therapeutic strategy.
Autor:
Chun-Hyung Kim, Hye Min Park, Xue-Wei Liu, Choong Hwan Lee, Bin Song, Sungwhan F. Oh, CongBao Kang, Sreekanth Rajan, Geraldine W.Y. Goh, Gregory A. Petsko, Aida Serra, Jeha Jeon, Hong Ye, Yongwoo Jang, Serap Beldar, Kah-Leong Lim, Woori Kim, Jun Yeob Yoo, Melissa Feitosa, Ho Sup Yoon, Dabin Hwang, Hui Ting Toh, Yeahan Kim, Kwang-Soo Kim, Julien Lescar
Publikováno v:
Nat Chem Biol
The orphan nuclear receptor Nurr1 is critical for the development, maintenance and protection of midbrain dopaminergic (mDA) neurons. Here we show that prostaglandin E1 (PGE1) and its dehydrated metabolite, PGA1, directly interact with the ligand-bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd588e0ced5ac7d9716ad1af8cedaca4
https://hdl.handle.net/10356/155280
https://hdl.handle.net/10356/155280
Publikováno v:
Oper Neurosurg (Hagerstown)
Background Surgical implantation of cellular grafts into the brain is of increasing importance, as stem cell-based therapies for Parkinson and other diseases continue to develop. The effect of grafting technique on development and survival of the gra