Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Melissa F Adasme"'
Autor:
Melissa F Adasme, Daniele Parisi, Kristien Van Belle, Sebastian Salentin, V Joachim Haupt, Gary S Jennings, Jörg-Christian Heinrich, Jean Herman, Ben Sprangers, Thierry Louat, Yves Moreau, Michael Schroeder
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233089 (2020)
Many drugs are promiscuous and bind to multiple targets. On the one hand, these targets may be linked to unwanted side effects, but on the other, they may achieve a combined desired effect (polypharmacology) or represent multiple diseases (drug repos
Externí odkaz:
https://doaj.org/article/682c47392a2d44ffb4edd44602bd8f10
Publikováno v:
Journal of Cheminformatics, Vol 14, Iss 1, Pp 1-14 (2022)
Abstract Background Structure-based drug repositioning has emerged as a promising alternative to conventional drug development. Regardless of the many success stories reported over the past years and the novel breakthroughs on the AI-based system Alp
Externí odkaz:
https://doaj.org/article/69d5be6e38364c658fff5d5ada41745a
Publikováno v:
Journal of Chemical Information and Modeling. 61:2248-2262
Pan-assay interference compounds (PAINS) are promiscuous compound classes that produce false positive hits in high-throughput screenings. Yet, the mechanisms of PAINS activity are poorly understood. Although PAINS are often associated with protein re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9c45ba8a8db267a67fdaee71d12fb4
https://doi.org/10.1021/acs.jcim.0c01227
https://doi.org/10.1021/acs.jcim.0c01227
Autor:
Deric M. Park, Evelin Schroeck, George P. Chrousos, Carlo Vittorio Cannistraci, Steven W. Poser, Polyxeni Nikolakopoulou, Alan McIntyre, Petra Lennig, Oliver Otto, Andreas Androutsellis-Theotokis, Carina Arps-Forker, Barbara Klink, Jochen Guck, Mathias Lesche, Andreas Dahl, Yan Ge, Ronen R. Leker, Konrad Gruetzmann, Maik Herbig, Stefan R. Bornstein, Marc Bickle, Melissa F. Adasme, Michael Schroeder, Cordula Andree, Szymon Stodolak
Publikováno v:
The FASEB Journal. 33:9235-9249
Cancer cells can switch between signaling pathways to regulate growth under different conditions. In the tumor microenvironment, this likely helps them evade therapies that target specific pathways. We must identify all possible states and utilize th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0bde03cf76eb099131fe2613915c099
https://doi.org/10.1096/fj.201802603rr
https://doi.org/10.1096/fj.201802603rr
Autor:
Daniele Parisi, Jörg-Christian Heinrich, V. Joachim Haupt, Melissa F. Adasme, Michael Schroeder, Kristien Van Belle, Thierry Louat, Gary Jennings, Yves Moreau, Jean Herman, Ben Sprangers, Sebastian Salentin
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 5, p e0233089 (2020)
PLoS ONE, Vol 15, Iss 5, p e0233089 (2020)
Many drugs are promiscuous and bind to multiple targets. On the one hand, these targets may be linked to unwanted side effects, but on the other, they may achieve a combined desired effect (polypharmacology) or represent multiple diseases (drug repos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65599f42f8b22eca2d778b555662a38
http://europepmc.org/articles/PMC7252619
http://europepmc.org/articles/PMC7252619
Autor:
Anastasia N. Sveshnikova, Yves Moreau, Michael Schroeder, Melissa F. Adasme, Sarah Naomi Bolz, Daniele Parisi
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 1043-1055 (2020)
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 1043-1055 (2020)
Drug repositioning aims to find new indications for existing drugs in order to reduce drug development cost and time. Currently,there are numerous stories of successful drug repositioning that have been reported and many repurposed drugs are already
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae6ad0825ce1da650b29981157f84f6d
https://pubmed.ncbi.nlm.nih.gov/32419905
https://pubmed.ncbi.nlm.nih.gov/32419905
Autor:
Sebastian Salentin, Melissa F. Adasme, Jörg C. Heinrich, V. Joachim Haupt, Simone Daminelli, Yixin Zhang, Michael Schroeder
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Drug repositioning identifies new indications for known drugs. Here we report repositioning of the malaria drug amodiaquine as a potential anti-cancer agent. While most repositioning efforts emerge through serendipity, we have devised a computational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b40c4aa7486303382e03b3fca262437d
http://europepmc.org/articles/PMC5595859
http://europepmc.org/articles/PMC5595859
Autor:
Daniele Parisi, Melissa F. Adasme, Anastasia Sveshnikova, Sarah Naomi Bolz, Yves Moreau, Michael Schroeder
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1043-1055 (2020)
Drug repositioning aims to find new indications for existing drugs in order to reduce drug development cost and time. Currently,there are numerous stories of successful drug repositioning that have been reported and many repurposed drugs are already
Externí odkaz:
https://doaj.org/article/1e8051b4767145ae845e811fe90dc165