Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Melissa E. Gove"'
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 690:102-107
Adiponectin (APN) is an adipose tissue-derived cytokine that regulates insulin sensitivity and inflammation. It is also involved in modulation of cell proliferation by binding to various growth factors. Based on its known effects in modulating cell p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43bd065562179c430f7f5c22e4142e74
https://doi.org/10.1016/j.mrfmmm.2009.06.014
https://doi.org/10.1016/j.mrfmmm.2009.06.014
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 296:G382-G387
The goal of this study was to investigate the role of the adipokine adiponectin (APN) in development of spontaneous colitis in IL-10 knockout (KO) mice. To this aim, we generated double IL-10 APN KO mice and compared their disease development to that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::608dbc483407d607d835d8ee70b3556b
https://doi.org/10.1152/ajpgi.90593.2008
https://doi.org/10.1152/ajpgi.90593.2008
Autor:
Maria Pini, Raja Fayad, Melissa E. Gove, Robert J. Cabay, Venkatesh Ponemone, Giamila Fantuzzi, Joseph A. Sennello, Charles A. Dinarello, Britta Siegmund
Publikováno v:
Proceedings of the National Academy of Sciences. 105:8085-8090
Obesity is associated with increased severity of acute pancreatitis (AP). The cytokines IL-18 and IL-12 are elevated in patients with AP, and IL-18 levels are high in obesity. We aimed to develop a pathologically relevant model to study obesity-assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec2a2c7f7727712c6ee674b0fb8f8c4
https://doi.org/10.1073/pnas.0804091105
https://doi.org/10.1073/pnas.0804091105
Autor:
Joseph A. Sennello, Melissa E. Gove, Jantine W. P. M. van Baal, Maria Pini, Lawrence Chan, Giamila Fantuzzi
Publikováno v:
Endocrinology. 149:4080-4085
Adipokines, cytokines mainly produced by adipocytes, are active participants in the regulation of inflammation. Administration of zymosan (ZY) was used to investigate the regulation and role of adipokines during peritonitis in mice. Injection of ZY l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e86dd9fc9233285b604a5dd004440a8
https://doi.org/10.1210/en.2008-0327
https://doi.org/10.1210/en.2008-0327
Publikováno v:
Cytokine. 36:261-266
Leptin-deficient ob/ob mice exhibit several metabolic and immune abnormalities, including thymus atrophy and markedly reduced inflammatory responses. We evaluated whether transplantation of wild type (WT) white adipose tissue (WAT) into ob/ob mice co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d2f5c97e21b9c8f42301f63134ac29
https://doi.org/10.1016/j.cyto.2007.02.001
https://doi.org/10.1016/j.cyto.2007.02.001
Publikováno v:
Obesity (Silver Spring, Md.). 18(12)
Leptin regulates appetite and metabolism but also immunity and inflammation. Although functional leptin receptors (LepR) are expressed on hematopoietic cells, the role of these receptors in regulating immune function in vivo remains controversial. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb68997f9ecaf030e1938ff27d0aeba
https://pubmed.ncbi.nlm.nih.gov/20395950
https://pubmed.ncbi.nlm.nih.gov/20395950
Autor:
Melissa E. Gove, Giamila Fantuzzi
Publikováno v:
Preventive Nutrition ISBN: 9781603275415
The traditional view of white adipose tissue (WAT) existing solely as an energy reservoir is no longer true. Although predominantly consisting of adipocytes, WAT is also composed of preadipocytes, endothelial cells, fibroblasts, and macrophages locat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d9b592fcd4c275f0f781cd4fdc6f337
https://doi.org/10.1007/978-1-60327-542-2_17
https://doi.org/10.1007/978-1-60327-542-2_17
We investigated the effect of adiponectin (APN) deficiency in the CD4(+)CD45RB(high) transfer model of colitis. Recombination activating gene (Rag)-1 knockout (KO) and Rag-1 APN KO mice receiving CD4(+)CD45RB(high) cells developed colitis of comparab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff0f097ef384b45804880a7f858cb28
https://europepmc.org/articles/PMC2754298/
https://europepmc.org/articles/PMC2754298/
Autor:
Maria Pini, Melissa E. Gove, Robert J. Cabay, Raja Fayad, Joseph A. Sennello, Martin G. Myers, Davina H. Rhodes, Giamila Fantuzzi, Jantine W. P. M. van Baal
Publikováno v:
Journal of leukocyte biology. 85(3)
Leptin-deficient ob/ob mice are resistant to dextran sulfate sodium (DSS)-induced colitis and Concanavalin A (Con A)-induced hepatitis. However, the signal transduction pathways involved have not been identified. The present study investigated the ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1e5f30f9dd81054517f2719c84c87a
https://pubmed.ncbi.nlm.nih.gov/19052144
https://pubmed.ncbi.nlm.nih.gov/19052144
Publikováno v:
Gastroenterology. 136:A-245
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53e43180b6354fb959fbca1de4885c99
https://doi.org/10.1016/s0016-5085(09)61107-0
https://doi.org/10.1016/s0016-5085(09)61107-0