Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Melissa D. Slugoski"'
Autor:
Edward Karpinski, Sylvia Y.M. Yao, Kyla M. Smith, James D. Young, Melissa D. Slugoski, Carol E. Cass, Stephen A. Baldwin, Amy M. L. Ng
Publikováno v:
Journal of Biological Chemistry. 284:17266-17280
Human concentrative nucleoside transporter 3 (hCNT3) utilizes electrochemical gradients of both Na(+) and H(+) to accumulate pyrimidine and purine nucleosides within cells. We have employed radioisotope flux and electrophysiological techniques in com
Autor:
Amy M. L. Ng, Queenie O.T. Lee, Edward Karpinski, Stephen A. Baldwin, Ras Mulinta, Ellen Morrison, Jing Zhang, Sylvia Y.M. Yao, Kyla M. Smith, Melissa D. Slugoski, James D. Young, Carol E. Cass
Publikováno v:
Journal of Biological Chemistry. 283:24922-24934
In humans, the SLC28 concentrative nucleoside transporter (CNT) protein family is represented by three Na+-coupled members; human CNT1 (hCNT1) and hCNT2 are pyrimidine and purine nucleoside-selective, respectively, whereas hCNT3 transports both purin
Autor:
Stephen A. Baldwin, Amy M. L. Ng, James D. Young, Edward Karpinski, Melissa D. Slugoski, Sylvia Y.M. Yao, Carol E. Cass, Ras Mulinta, Kyla M. Smith
Publikováno v:
Journal of Biological Chemistry. 282:30607-30617
Human concentrative nucleoside transporter 1 (hCNT1), the first discovered of three human members of the SLC28 (CNT) protein family, is a Na+/nucleoside cotransporter with 650 amino acids. The potential functional roles of 10 conserved aspartate and
Autor:
Edward Karpinski, James D. Young, Amy M. L. Ng, Sylvia Y.M. Yao, Stephen A. Baldwin, Carol E. Cass, Shaun K. Loewen, Kyla M. Smith, Melissa D. Slugoski
Publikováno v:
Biochemistry. 46:1684-1693
The Na + /nudeoside cotransporters hCNT1 (650 residues) and hCNT2 (658 residues) are 72% identical in amino acid sequence and contain 13 putative transmembrane helices (TMs). Both transport uridine and adenosine but are otherwise selective for pyrimi
Autor:
Joel H. Weiner, Raymond J. Turner, Carol E. Cass, Sylvia Y.M. Yao, Peter J F Henderson, John R. Mackey, Nadira N Mohabir, Melissa D. Slugoski, Shaun K. Loewen, Stephen A Baldwin, James Young, Maurice P Gallagher
Publikováno v:
Molecular Membrane Biology. 21:1-10
The recently identified human and rodent plasma membrane proteins CNT1, CNT2 and CNT3 belong to a gene family (CNT) that also includes the bacterial nucleoside transport protein NupC. Heterologous expression in Xenopus oocytes has established that CN
Autor:
Sylvia Y.M. Yao, Carol E. Cass, Melissa D. Slugoski, Ras Mulinta, Stephen A. Baldwin, Colin C. Lin, James D. Young, Amy M. L. Ng
Publikováno v:
The Journal of biological chemistry. 284(25)
The human SLC28 family of integral membrane CNT (concentrative nucleoside transporter) proteins has three members, hCNT1, hCNT2, and hCNT3. Na(+)-coupled hCNT1 and hCNT2 transport pyrimidine and purine nucleosides, respectively, whereas hCNT3 mediate
Autor:
Amy M. L. Ng, Jing Zhang, Edward Karpinski, Colin C. Lin, Kyla M. Smith, Carol E. Cass, James D. Young, Sylvia Y.M. Yao, Stephen A. Baldwin, Melissa D. Slugoski
Publikováno v:
The Journal of biological chemistry. 283(13)
The concentrative nucleoside transporter (CNT) protein family in humans is represented by three members, hCNT1, hCNT2, and hCNT3. Belonging to a CNT subfamily phylogenetically distinct from hCNT1/2, hCNT3 mediates transport of a broad range of purine
Autor:
Melissa D. Slugoski, Edward Karpinski, Carol E. Cass, Kyla M. Smith, Stephen A. Baldwin, James D. Young
Publikováno v:
Molecular membrane biology. 24(1)
The SLC28 family of concentrative nucleoside transporter (CNT) proteins in mammalian cells contains members of two distinct phylogenic subfamilies. In humans, hCNT1 and hCNT2 belong to one subfamily, and hCNT3 to the other. All three CNTs mediate inw
Autor:
Xuejun Sun, Tracey Tackaberry, Carol E. Cass, Stephen A. Baldwin, Jing Zhang, Melissa D. Slugoski, Lars P. C. Nielsen, Pat Carpenter, Kyla M. Smith, Morris J. Robins, Ireneusz Nowak, James D. Young
Publikováno v:
The Journal of biological chemistry. 281(38)
The uptake of Urd into the yeast Saccharomyces cerevisiae is mediated by Fui1p, a Urd-specific nucleoside transporter encoded by the FUI1 gene and a member of the yeast Fur permease family, which also includes the uracil, allantoin, and thiamine perm
Autor:
Edward Karpinski, Amy M. L. Ng, Stephen A. Baldwin, Carol E. Cass, Xing-Zhen Chen, James D. Young, Shaun K. Loewen, Kyla M. Smith, Melissa D. Slugoski, Sylvia Y.M. Yao
Publikováno v:
The Journal of biological chemistry. 280(27)
The concentrative nucleoside transporter (CNT) protein family in humans is represented by three members, hCNT1, hCNT2, and hCNT3. hCNT3, a Na+/nucleoside symporter, transports a broad range of physiological purine and pyrimidine nucleosides as well a