Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Melissa D. Conrad"'
Autor:
Patrick K. Tumwebaze, Melissa D. Conrad, Martin Okitwi, Stephen Orena, Oswald Byaruhanga, Thomas Katairo, Jennifer Legac, Shreeya Garg, David Giesbrecht, Sawyer R. Smith, Frida G. Ceja, Samuel L. Nsobya, Jeffrey A. Bailey, Roland A. Cooper, Philip J. Rosenthal
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
In this work, susceptibilities to two key antimalarials, dihydroartemisinin and lumefantrine, were associated with multiple genetic polymorphisms in Plasmodium falciparum, and were lower in northern Uganda, where resistance-mediating mutations have e
Externí odkaz:
https://doaj.org/article/187a57e02f454e7cb07950de76fde6a6
Autor:
Oriana Kreutzfeld, Patrick K. Tumwebaze, Martin Okitwi, Stephen Orena, Oswald Byaruhanga, Thomas Katairo, Melissa D. Conrad, Stephanie A. Rasmussen, Jennifer Legac, Ozkan Aydemir, David Giesbrecht, Barbara Forte, Peter Campbell, Alasdair Smith, Hiroki Kano, Samuel L. Nsobya, Benjamin Blasco, Maelle Duffey, Jeffrey A. Bailey, Roland A. Cooper, Philip J. Rosenthal
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Malaria, especially Plasmodium falciparum infection, remains an enormous problem, and its treatment and control are seriously challenged by drug resistance. New antimalarial drugs are needed. To characterize the Medicines for Malaria Venture
Externí odkaz:
https://doaj.org/article/373b8efbdb7d4e76aea7095c81c6a1bf
Autor:
Marvin Duvalsaint, Melissa D. Conrad, Stephen Tukwasibwe, Patrick K. Tumwebaze, Jennifer Legac, Roland A. Cooper, Philip J. Rosenthal
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-9 (2021)
Abstract Background Anti-malarial drug resistance may be limited by decreased fitness in resistant parasites. Important contributors to resistance are mutations in the Plasmodium falciparum putative drug transporter PfMDR1. Methods Impacts on in vitr
Externí odkaz:
https://doaj.org/article/4efc2707118f4d0781ebdac49229c810
Autor:
Sam L. Nsobya, Andrew Walakira, Elizabeth Namirembe, Moses Kiggundu, Joaniter I. Nankabirwa, Emmanuel Ruhamyankaka, Emmanuel Arinaitwe, Melissa D. Conrad, Moses R. Kamya, Grant Dorsey, Philip J. Rosenthal
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-6 (2021)
Abstract Background Rapid diagnostic tests (RDTs) play a key role in malaria case management. The most widely used RDT identifies Plasmodium falciparum based on immunochromatographic recognition of P. falciparum histidine-rich protein 2 (PfHRP2). Del
Externí odkaz:
https://doaj.org/article/f47ea82463444c419018d31e5abc4629
Autor:
Alex K. Musiime, David L. Smith, Maxwell Kilama, Otto Geoffrey, Patrick Kyagamba, John Rek, Melissa D. Conrad, Joaniter I. Nankabirwa, Emmanuel Arinaitwe, Anne M. Akol, Moses R. Kamya, Grant Dorsey, Sarah G. Staedke, Chris Drakeley, Steve W. Lindsay
Publikováno v:
Malaria Journal, Vol 19, Iss 1, Pp 1-15 (2020)
Abstract Background Over the last two decades, there has been remarkable progress in malaria control in sub-Saharan Africa, due mainly to the massive deployment of long-lasting insecticidal nets and indoor residual spraying. Despite these gains, it i
Externí odkaz:
https://doaj.org/article/41225e80a72a456b9234c18c09d8cc95
Autor:
Alex K. Musiime, Paul J. Krezanoski, David L. Smith, Maxwell Kilama, Melissa D. Conrad, Geoffrey Otto, Patrick Kyagamba, Jackson Asiimwe, John Rek, Joaniter I. Nankabirwa, Emmanuel Arinaitwe, Anne M. Akol, Moses R. Kamya, Sarah G. Staedke, Chris Drakeley, Teun Bousema, Steve W. Lindsay, Grant Dorsey, Lucy S. Tusting
Publikováno v:
PLOS Global Public Health, Vol 2, Iss 3 (2022)
House construction is rapidly modernizing across Africa but the potential benefits for human health are poorly understood. We hypothesised that improvements to housing would be associated with reductions in malaria, acute respiratory infection (ARI)
Externí odkaz:
https://doaj.org/article/c3b3235d42d54bc9a5ca52ae51e116ff
Autor:
Alex K. Musiime, David L. Smith, Maxwell Kilama, John Rek, Emmanuel Arinaitwe, Joaniter I. Nankabirwa, Moses R. Kamya, Melissa D. Conrad, Grant Dorsey, Anne M. Akol, Sarah G. Staedke, Steve W. Lindsay, James P. Egonyu
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-9 (2019)
Abstract Background Long-lasting insecticidal nets (LLINs) and indoor residual spraying of insecticide (IRS) are widely recommended for the prevention of malaria in endemic regions. Data from human landing catches provide information on the impact of
Externí odkaz:
https://doaj.org/article/a6cd415f6e174df6b2ed31d2ef0e7e28
Autor:
Michelle E Roh, Issaka Zongo, Alassane Haro, Liusheng Huang, Anyirékun Fabrice Somé, Rakiswendé Serge Yerbanga, Melissa D Conrad, Erika Wallender, Jennifer Legac, Francesca Aweeka, Jean-Bosco Ouédraogo, Philip J Rosenthal
Publikováno v:
The Journal of Infectious Diseases.
Background Despite scale-up of seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine and amodiaquine (SP-AQ) in children Methods We enrolled 310 children presenting at health facilities in Bobo-Dioulasso. Cases were SMC-eligible child
Autor:
John Rek, Sara Lynn Blanken, Joseph Okoth, Daniel Ayo, Ismail Onyige, Eric Musasizi, Jordache Ramjith, Chiara Andolina, Kjerstin Lanke, Emmanuel Arinaitwe, Peter Olwoch, Katharine A Collins, Moses R Kamya, Grant Dorsey, Chris Drakeley, Sarah G Staedke, Teun Bousema, Melissa D Conrad
Publikováno v:
The Journal of Infectious Diseases
The Journal of Infectious Diseases, 226, 4, pp. 708-713
The Journal of Infectious Diseases, 226, 708-713
The Journal of Infectious Diseases, 226, 4, pp. 708-713
The Journal of Infectious Diseases, 226, 708-713
Contains fulltext : 282499.pdf (Publisher’s version ) (Open Access) Achieving malaria elimination requires a better understanding of the transmissibility of human infections in different transmission settings. This study aimed to characterize the h
Autor:
Stephen Orena, Frida G. Ceja, Brett R. Bayles, Melissa D. Conrad, Thomas Katairo, Jennifer Legac, Jeffrey A. Bailey, Martin Okitwi, Philip J. Rosenthal, Sevil Chelebieva, Stephanie A Rasmussen, Victor Asua, Roland A. Cooper, Samuel L. Nsobya, Oswald Byaruhanga, Ozkan Aydemir, Marvin Duvalsaint, Patrick K Tumwebaze
Publikováno v:
The Lancet Microbe, Vol 2, Iss 9, Pp e441-e449 (2021)
The Lancet. Microbe
The Lancet. Microbe
Summary: Background: Treatment and control of malaria depends on artemisinin-based combination therapies (ACTs) and is challenged by drug resistance, but thus far resistance to artemisinins and partner drugs has primarily occurred in southeast Asia.