Recellularization of a novel off-the-shelf valve following xenogenic implantation into the right ventricular outflow tract.

Autor: Ryan S Hennessy, Jason L Go, Rebecca R Hennessy, Brandon J Tefft, Soumen Jana, Nicholas J Stoyles, Mohammed A Al-Hijji, Jeremy J Thaden, Sorin V Pislaru, Robert D Simari, John M Stulak, Melissa D Young, Amir Lerman

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0181614 (2017)

Current research on valvular heart repair has focused on tissue-engineered heart valves (TEHV) because of its potential to grow similarly to native heart valves. Decellularized xenografts are a promising solution; however, host recellularization rema

Externí odkaz: https://doaj.org/article/dd3376d2db24494bae592aa8c5b11f49

Rate-Dependent and Relaxation Properties of Porcine Aortic Heart Valve Biomaterials

Autor: Christopher Noble, Amir Lerman, Michael Kamykowski, Melissa D. Young

Publikováno v: IEEE open journal of engineering in medicine and biology
IEEE Open Journal of Engineering in Medicine and Biology, Vol 1, Pp 197-202 (2020)

Objective: This work evaluates the rate-dependent and relaxation properties of native porcine heart valves, glutaraldehyde fixed porcine pericardium, and decellularized sterilized porcine pericardium. Methods: Biaxial tension testing was performed at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298dd070d8c5aedfe1e2f619479074b3
http://europepmc.org/articles/PMC7971416

Biomaterial characterization of off-the-shelf decellularized porcine pericardial tissue for use in prosthetic valvular applications

Autor: Jason L. Go, Amir Lerman, Brandon J. Tefft, Soumen Jana, Ryan S. Hennessy, Melissa D. Young, Joshua A. Choe, David Morse

Publikováno v: Journal of Tissue Engineering and Regenerative Medicine

Fixed pericardial tissue is commonly used for commercially available xenograft valve implants, and has proven durability, but lacks the capability to remodel and grow. Decellularized porcine pericardial tissue has the promise to outperform fixed tiss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c96e71358edd9eadacbf9d01d4e0bab
https://doi.org/10.1002/term.2686

Mechanical and finite element evaluation of a bioprinted scaffold following recellularization in a rat subcutaneous model

Autor: Eva L. Maxson, Christopher Noble, Melissa D. Young, Amir Lerman

Publikováno v: J Mech Behav Biomed Mater

Tissue engineered heart valves (TEHV) provide several advantages over currently available aortic heart valve replacements. Bioprinting provides a patient-specific means of developing a TEHV scaffold from imaging data, and the capability to embed the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cfd929670b36c768c5e94f52b70b5f9
https://pubmed.ncbi.nlm.nih.gov/31879268

In Vivo Response of Acellular Porcine Pericardial for Tissue Engineered Transcatheter Aortic Valves

Autor: Amir Lerman, Jason L. Go, Christopher Noble, Melissa D. Young, David Morse, Reza Khorramirouz

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)

Current heart valve prostheses have limitations that include durability, inability to grow in pediatric patients, and lifelong anticoagulation. Transcatheter aortic valve replacements are minimally invasive procedures, and therefore have emerged as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc630b53893318ea89edf746b8e97ce3
http://europepmc.org/articles/PMC6355869