Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Melissa Czajkowski"'
Autor:
Eveline de Rijk, Manon Beekhuijzen, Ankie Lambregts, Melissa Czajkowski, Hetty van den Brink-Knol
Publikováno v:
Toxicologic Pathology. 50:466-477
For toxicology testing of (agro)chemicals, different study types are being performed with general and/or reproductive toxicity endpoints (see Organisation for Economic Co-operation and Development guidelines). In most of these rat studies, vaginal cy
Autor:
Ahamat Aboulmali, Bethany Balmer, Daniel Petkov, Alys Bradley, Daniel J. Patrick, Paul C. Howroyd, Petrina Rogerson, Gayle Hennig, Melissa Czajkowski, David A Rehagen, Joshua H. Decker
Publikováno v:
Toxicologic Pathology. 50:4-12
Aneurysms of the ascending aorta, unrelated to xenobiotic administration, are described in 5 rats and 2 mice in nonclinical safety studies conducted at Charles River Laboratories (CRL) sites over the past 10 years. The most prominent microscopic find
Autor:
Maurice G Cary, Alys Bradley, Matthew Smith, Warren Harvey, Melissa Czajkowski, Stuart W. Naylor
Publikováno v:
Toxicologic Pathology. 47:165-173
Biotherapeutics are pharmaceutical products derived from or synthesized by biological systems. Such molecules carry the potential for immunogenicity which may lead to adverse immune responses. The cynomolgus macaque ( Macaca fascicularis) is the spec
Autor:
Michael J. Graziano, Solomon Haile, John R. Foster, Bassem Attalla, Magnus Söderberg, Evan B. Janovitz, Shen-Jue Chen, Karen Granaldi, Yunling Song, Mark Tirmenstein, Martin Billger, Thomas Dorr, Raja Mangipudy, Kristina D. Chadwick, Ann-Marie Bergholm, Melissa Czajkowski
Publikováno v:
Toxicologic pathology. 46(2)
The purpose of this study was to establish a 2-stage model of urinary bladder carcinogenesis in male Sprague-Dawley rats to identify tumor promoters. In phase 1 of the study, rats ( n = 170) were administered 100 mg/kg of the tumor initiator, N-butyl
Publikováno v:
Veterinary dermatology. 19(3)
Previously reported cases of congenital cutaneous mast cell tumours in calves were characterized by multiple discrete nodules. The calf presented herein is, to the authors' knowledge, the first documented case of congenital diffuse cutaneous mastocyt
Autor:
Petkov D; 57146Charles River Laboratories, Edinburgh, United Kingdom., Patrick DJ; 537465Charles River Laboratories, Mattawan, MI, USA., Rogerson P; 57146Charles River Laboratories, Edinburgh, United Kingdom., Rehagen D; 537465Charles River Laboratories, Mattawan, MI, USA., Hennig G; 70294Charles River Laboratories, Senneville, Quebec, Canada., Bradley A; 57146Charles River Laboratories, Edinburgh, United Kingdom., Howroyd P; 57146Charles River Laboratories, Edinburgh, United Kingdom., Czajkowski M; Melissa Czajkowski, 26135Charles River Laboratories, 's-Hertogenbosch, the Netherlands. Petkov is now with Frontage Laboratories, Concord, OH, USA; Patrick is now with Eli Lilly and Company, Indianapolis, IN, USA., Decker J; 537465Charles River Laboratories, Mattawan, MI, USA., Aboulmali A; 70294Charles River Laboratories, Senneville, Quebec, Canada., Balmer B; 537465Charles River Laboratories, Mattawan, MI, USA.
Publikováno v:
Toxicologic pathology [Toxicol Pathol] 2022 Jan; Vol. 50 (1), pp. 4-12. Date of Electronic Publication: 2021 Dec 02.