Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Melissa C. Zhang"'
Autor:
Kevin R. Shreder, Tyzoon K. Nomanbhoy, Ayako Nakamura, Anna Katrin Szardenings, Shigeki Seto, Jonathan S. Rosenblum, Brandon Leen, Oana Cociorva, Kai Nakamura, Bei Li, Marek Liyanage, John W. Kozarich, Qiang Li, Yasushi Kohno, Kazuhiro Yumoto, Kyoko Okada, Masahiro Nomura, Melissa C. Zhang, Arwin Aban
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5948-5951
The synthesis, GSK-3β inhibitory activity, and anti-microbial activity of bicyclic and tricyclic derivatives of the 5,7-diamino-6-fluoro-4-quinolone-3-carboxylic acid scaffold were studied. Kinase selectivity profiling indicated that members of this
Autor:
Melissa C. Zhang, Min Wu, Melissa Wong, Kevin Shreder, Sergio Corral, Yi Hu, Lisa Morera, Lifu Ma, Emme C.K. Lin, John W. Kozarich, Doris Pik-Yiu Chun
Publikováno v:
Letters in Drug Design & Discovery. 5:340-345
Autor:
Thomas M. Grogan, Christopher Prusinkiewicz, Dianlin Guo, Anna Janowska-Wieczorek, Stefan J. Urbanski, Melissa C. Zhang, Leah A. Marquez, Dylan R. Edwards, Anna E. Kossakowska
Publikováno v:
Blood. 94:2080-2089
We showed previously that human malignant non-Hodgkin’s lymphomas (NHL) degrade extracellular matrix (ECM) components through the action of metalloproteinases and that elevated expression of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor o
Autor:
Leah A. Marquez, Lynn K. Boshkov, Dylan R. Edwards, Anna Janowska-Wieczorek, A. R. Turner, Melissa C. Zhang, Haroon Hashmi, Akinobu Matsuzaki, Anna E. Kossakowska, Lori Larratt
Publikováno v:
British Journal of Haematology. 105:402-411
We compared the expression of matrix metalloproteinases (MMP-2 and MMP-9) and tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in bone marrow acute myelogenous leukaemia (AML) blasts and leukaemic cell lines (HEL, HL-60, K-562 and KG-1) wi
Autor:
Kai Nakamura, Qiang Li, Tyzoon K. Nomanbhoy, Ann Yu-Jung Shih, Helge Weissig, Oana Cociorva, Lan Pham, John W. Kozarich, Yi Hu, Melissa C. Zhang, Marek Liyanage, Julia Cajica, Kevin R. Shreder, Arwin Aban, Bei Li
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(18)
As the result of a rhJNK1 HTS, the imidazo[1,2-a]quinoxaline 1 was identified as a 1.6 μM rhJNK1 inhibitor. Optimization of this compound lead to AX13587 (rhJNK1 IC50 = 160 nM) which was co-crystallized with JNK1 to identify key molecular interactio
Autor:
Tyzoon K. Nomanbhoy, Melissa C. Zhang, Kai Nakamura, Oana Cociorva, Kazuhiro Yumoto, Anna Katrin Szardenings, John W. Kozarich, Bei Li, Marek Liyanage, Yasushi Kohno, Kyoko Okada, Kevin R. Shreder, Masahiro Nomura, Qiang Li, Arwin Aban
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(2)
We previously disclosed tricylic, 6-carboxylic acid-bearing 4-quinolones as GSK-3β inhibitors. Herein we discuss the optimization of this series to yield a series of more potent 6-nitrile analogs with insignificant anti-microbial activity. Finally,
Publikováno v:
Clinical Proteomics. 1(3-4):301-312
The evaluation of clinical tumor tissues is a valuable approach to discovering novel drug targets because of the direct relevance of human samples. We used activity-based proteomic profiling (ABPP) to study the differences in serine hydrolase activit