Zobrazeno 1 - 10
of 300
pro vyhledávání: '"Melissa C Skala"'
Autor:
Anna Hoefges, Paul M Sondel, Alexander L Rakhmilevich, Arika S Feils, Alina A Hampton, Noah W Tsarovsky, Amy K Erbe-Gurel, Alexa R Heaton, Nathaniel J Burkard, Garrett M Lublin, Melissa C Skala
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/4974d29cc9e9470d91ac46ce206f9c5d
Autor:
Veronika Miskolci, Kelsey E Tweed, Michael R Lasarev, Emily C Britt, Alex J Walsh, Landon J Zimmerman, Courtney E McDougal, Mark R Cronan, Jing Fan, John-Demian Sauer, Melissa C Skala, Anna Huttenlocher
Publikováno v:
eLife, Vol 11 (2022)
The function of macrophages in vitro is linked to their metabolic rewiring. However, macrophage metabolism remains poorly characterized in situ. Here, we used two-photon intensity and lifetime imaging of autofluorescent metabolic coenzymes, nicotinam
Externí odkaz:
https://doaj.org/article/8206c968188744b0808bd43cb3275c27
Autor:
Woojong Lee, Brock Kingstad-Bakke, Brett Paulson, Autumn Larsen, Katherine Overmyer, Chandranaik B Marinaik, Kelly Dulli, Randall Toy, Gabriela Vogel, Katherine P Mueller, Kelsey Tweed, Alex J Walsh, Jason Russell, Krishanu Saha, Leticia Reyes, Melissa C Skala, John-Demian Sauer, Dmitry M Shayakhmetov, Joshua Coon, Krishnendu Roy, M Suresh
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009168 (2021)
There is a critical need for adjuvants that can safely elicit potent and durable T cell-based immunity to intracellular pathogens. Here, we report that parenteral vaccination with a carbomer-based adjuvant, Adjuplex (ADJ), stimulated robust CD8 T-cel
Externí odkaz:
https://doaj.org/article/73580a7e1e6e47af817c8a1751850e37
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170415 (2017)
Head and neck cancer patients suffer from toxicities, morbidities, and mortalities, and these ailments could be minimized through improved therapies. Drug discovery is a long, expensive, and complex process, so optimized assays can improve the succes
Externí odkaz:
https://doaj.org/article/7ccbbf539d114c58abda4983afb92b6a
Autor:
Amy T Shah, Michelle Demory Beckler, Alex J Walsh, William P Jones, Paula R Pohlmann, Melissa C Skala
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90746 (2014)
Optical metabolic imaging measures fluorescence intensity and lifetimes from metabolic cofactors nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD). These molecular level measurements provide unique biomarkers for early ce
Externí odkaz:
https://doaj.org/article/98c9dbfc2d3b4e6d9b2e8bcd605ce861
Autor:
Kayvan Samimi, Emmanuel Contreras Guzman, May Wu, Lindsey Carlson, Helen Feltovich, Timothy J. Hall, Kristin M. Myers, Michelle L. Oyen, Melissa C. Skala
Publikováno v:
Biomed Opt Express
Fetal membranes have important mechanical and antimicrobial roles in maintaining pregnancy. However, the small thickness (ex vivo properties of human fetal membranes under dynamic loading. A saline inflation test was incorporated into an OCT system,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf1c167f8acebf51405693a3eb27274
https://europepmc.org/articles/PMC10278609/
https://europepmc.org/articles/PMC10278609/
Supplementary Figure S1 from MTORC1/2 Inhibition as a Therapeutic Strategy for PIK3CA Mutant Cancers
Autor:
Dustin A. Deming, Melissa C. Skala, Michael A. Newton, Kristina A. Matkowskyj, Paraic A. Kenny, Benjamin M. Parsons, Kayla K. Lemmon, Mark E. Burkard, Linda Clipson, Rebecca A. DeStefanis, Gioia Chengcheng Sha, Demetra P. Korkos, Mitchell G. Depke, Dana R. Van De Hey, Alexander E. Yueh, Tyler M. Foley, Cheri A. Pasch, Jeremy D. Kratz, Peter F. Favreau, Susan N. Payne, Stephanie L. Fricke
Supplementary Figure S1 presents the viability of SW48 and SW48PK cells after treatment with BEZ235 and TAK-228 at the 100-400nM concentrations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3797d51c82d44138bbd5766b7be6a207
https://doi.org/10.1158/1535-7163.22507717.v1
https://doi.org/10.1158/1535-7163.22507717.v1
Autor:
Dustin A. Deming, Melissa C. Skala, Michael A. Newton, Kristina A. Matkowskyj, Paraic A. Kenny, Benjamin M. Parsons, Kayla K. Lemmon, Mark E. Burkard, Linda Clipson, Rebecca A. DeStefanis, Gioia Chengcheng Sha, Demetra P. Korkos, Mitchell G. Depke, Dana R. Van De Hey, Alexander E. Yueh, Tyler M. Foley, Cheri A. Pasch, Jeremy D. Kratz, Peter F. Favreau, Susan N. Payne, Stephanie L. Fricke
PIK3CA mutations are common in clinical molecular profiling, yet an effective means to target these cancers has yet to be developed. MTORC1 inhibitors are often used off-label for patients with PIK3CA mutant cancers with only limited data to support
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61eef4938e53e1487200610ced459f4f
https://doi.org/10.1158/1535-7163.c.6538765.v1
https://doi.org/10.1158/1535-7163.c.6538765.v1
Supplementary figures 1-5 and supplementary tables 1-3. Supplementary Figure 1: Fluorescence lifetimes of NAD(P)H and FAD exhibit differences between macrophage polarization states. Supplementary Figure 2: Validation of two-photon wavelength mixing f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85cdab703e2c49a6cdb5e2b698910a3b
https://doi.org/10.1158/0008-5472.22426189.v1
https://doi.org/10.1158/0008-5472.22426189.v1
Autor:
Dustin A. Deming, Melissa C. Skala, Randall J. Kimple, Michael F. Bassetti, Irene M. Ong, Michael A. Newton, Kristina A. Matkowskyj, Kayla K. Lemmon, Mark E. Burkard, Evie H. Carchman, Devon Miller, Christine M. Walsh, Linda Clipson, Demetra P. Korkos, Susan N. Payne, Rosabella T. Pitera, Rebecca A. DeStefanis, Philip B. Emmerich, Carley M. Sprackling, Alyssa K. DeZeeuw, Kwangok P. Nickel, Mohammad Rezaul Karim, Joe T. Sharick, Amani A. Gillette, Christopher P. Babiarz, Alexander E. Yueh, Peter F. Favreau, Cheri A. Pasch
Dot plots corresponding to population distribution curves and graphs of individual replicates for bar graphs in Figure 4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7330c7bce5376c4f183eb6067b2815ec
https://doi.org/10.1158/1078-0432.22469583
https://doi.org/10.1158/1078-0432.22469583