The different natural estrogens promote endothelial healing through distinct cell targets

Autor: Morgane Davezac, Rana Zahreddine, Melissa Buscato, Natalia F. Smirnova, Chanaelle Febrissy, Henrik Laurell, Silveric Gilardi-Bresson, Marine Adlanmerini, Philippe Liere, Gilles Flouriot, Rachida Guennoun, Muriel Laffargue, Jean-Michel Foidart, Françoise Lenfant, Jean-François Arnal, Raphaël Métivier, Coralie Fontaine

Publikováno v: JCI Insight, Vol 8, Iss 5 (2023)

The main estrogen, 17β-estradiol (E2), exerts several beneficial vascular actions through estrogen receptor α (ERα) in endothelial cells. However, the impact of other natural estrogens such as estriol (E3) and estetrol (E4) on arteries remains poo

Externí odkaz: https://doaj.org/article/cee391bdb2374d7ba32e1f7c699de3f8

Selective Liver Estrogen Receptor α Modulation Prevents Steatosis, Diabetes, and Obesity Through the Anorectic Growth Differentiation Factor 15 Hepatokine in Mice

Autor: Maeva Guillaume, Elodie Riant, Aurélie Fabre, Isabelle Raymond‐Letron, Melissa Buscato, Morgane Davezac, Blandine Tramunt, Alexandra Montagner, Sarra Smati, Rana Zahreddine, Gaëlle Palierne, Marie‐Cécile Valera, Hervé Guillou, Françoise Lenfant, Klaus Unsicker, Raphaël Metivier, Coralie Fontaine, Jean‐François Arnal, Pierre Gourdy

Publikováno v: Hepatology Communications, Vol 3, Iss 7, Pp 908-924 (2019)

Hepatocyte estrogen receptor α (ERα) was recently recognized as a relevant molecular target for nonalcoholic fatty liver disease (NAFLD) prevention. The present study defined to what extent hepatocyte ERα could be involved in preserving metabolic

Externí odkaz: https://doaj.org/article/abefe13400694a3ab2acdc1d9aad812d

A historical view of estrogen effect on arterial endothelial healing: From animal models to medical implication

Autor: Coralie Fontaine, Melissa Buscato, Morgane Davezac, Jean-François Arnal, Rana Zahreddine, Natalia F. Smirnova, Marine Adlanmerini, Daniel Henrion, Muriel Laffargue, Françoise Lenfant

Publikováno v: Atherosclerosis. 338:30-38

Endothelial barrier integrity is required for maintaining vascular homeostasis and fluid balance between the circulation and surrounding tissues. In contrast, abnormalities of endothelial cell function and loss of the integrity of the endothelial mon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9ada727ace1ec99314e01d66667dc0e
https://doi.org/10.1016/j.atherosclerosis.2021.10.013

Tamoxifen Accelerates Endothelial Healing by Targeting ERα in Smooth Muscle Cells

Autor: Alexia Vinel, Marie-Ange Renault, Françoise Lenfant, Emeline Lhuillier, Adrien Lupieri, Alain-Pierre Gadeau, Natalia F. Smirnova, Melissa Buscato, Morgane Davezac, Coralie Fontaine, Romain Solinhac, Raphaël Métivier, Gilles Flouriot, Emilie Vessieres, Rana Zahreddine, Jean-François Arnal, Daniel Henrion, Muriel Laffargue

Publikováno v: Circulation Research
Circulation Research, 2020, 127 (12), pp.1473-1487. ⟨10.1161/CIRCRESAHA.120.317062⟩
Circulation Research, American Heart Association, 2020, 127 (12), pp.1473-1487. ⟨10.1161/CIRCRESAHA.120.317062⟩
Circulation Research, American Heart Association, 2020, ⟨10.1161/CIRCRESAHA.120.317062⟩
Circ Res

Rationale: Tamoxifen prevents the recurrence of breast cancer and is also beneficial against bone demineralization and arterial diseases. It acts as an ER (estrogen receptor) α antagonist in ER-positive breast cancers, whereas it mimics the protecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a26b3f12b32b3f5dc38ddf5ff3260c78
https://hal.science/hal-03040722/document

The tissue-specific effects of different 17β-estradiol doses reveal the key sensitizing role of AF1 domain in ERα activity

Autor: Frank Giton, Alexia Vinel, Claes Ohlsson, Melissa Buscato, Alain Milon, Sung Hoon Kim, Françoise Lenfant, Pierre Gourdy, Benita S. Katzenellenbogen, Gilles Flouriot, Coralie Fontaine, Isabelle Raymond-Letron, Jean-François Arnal, John A. Katzenellenbogen

Publikováno v: Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology, Elsevier, 2020, 505, pp.110741. ⟨10.1016/j.mce.2020.110741⟩
Molecular and Cellular Endocrinology, 2020, 505, pp.110741. ⟨10.1016/j.mce.2020.110741⟩

International audience; 17β-Estradiol (E2) action can be mediated by the full-length estrogen receptor alpha (ERα66), and also by the AF1 domain-deficient ERα (ERα46) isoform, but their respective sensitivity to E2 is essentially unknown. We firs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191cfb2cbd10847cc3d5cc82ae12d120
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02470890/document