Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Melissa Birch"'
Publikováno v:
Organic Process Research & Development. 17:1345-1358
Agitated filter-dryers (AFDs) are commonly used for performing both filtration and drying operations in the manufacture of active pharmaceutical ingredients (APIs) and intermediates. Successful scale-up from the laboratory to manufacturing AFD equipm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c488c0ae69332fc1f34bdb12b3f5ef9
https://doi.org/10.1021/op400080x
https://doi.org/10.1021/op400080x
Autor:
Melissa Birch, Ivan Marziano
Publikováno v:
Organic Process Research & Development. 17:1359-1366
A systematic investigation into possible causes of agglomeration during drying was carried out, with a view to reduce the amount of agglomerates present in an active pharmaceutical ingredient. Several tools used in this study are described, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2ad70db7f7fa1bb5016474103e5049d
https://doi.org/10.1021/op4000972
https://doi.org/10.1021/op4000972
Autor:
Jean-Philippe Crochard, Melissa Birch, Amy Luan, Jinu S. Mathew, Philip Peach, Neil McDowall, David Sebastien Fradet, Stephen Challenger, Kevin Meldrum, Charles M. Gordon, Hayley Jackman, Stephen Yeo, Evelyn Madigan
Publikováno v:
Organic Process Research & Development. 15:1358-1364
The development of a highly efficient two-step process for the manufacture of the α2δ-ligand imagabalin hydrochloride 1 is described in 50% overall yield from (R)-3-methylhexanoic acid 2. Key aspec...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9685f05fa65964e82bc79b3bfd7a2f4a
https://doi.org/10.1021/op2002326
https://doi.org/10.1021/op2002326
Autor:
Magnus Widegren, Hayley Jackman, Jean-Philippe Crochard, Melissa Birch, Kevin Meldrum, Stephen Challenger, Amy Luan, David Sebastien Fradet, Neil McDowall, Charles M. Gordon, Evelyn Madigan, Stephen Yeo
Publikováno v:
Organic Process Research & Development. 15:1172-1177
The development and implementation of a robust process for the manufacture of metric ton quantities of the α2δ ligand imagabalin hydrochloride 4 is described. Key aspects of the synthesis include a...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0675fe296642f354a99b5be242772fb
https://doi.org/10.1021/op2001639
https://doi.org/10.1021/op2001639
Publikováno v:
Organic Process Research & Development. 12:1104-1113
A six-step synthetic route to the CCR-5 receptor antagonist, Maraviroc (UK-427,857) (1) has been developed and demonstrated at scale in a pilot plant. The route has supported four Pilot-Plant campa...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c72a50660bb4b6cae4c5db7c011e72e
https://doi.org/10.1021/op800062d
https://doi.org/10.1021/op800062d
Publikováno v:
Organic Process Research & Development. 9:360-364
A strategy for the rapid, material-efficient development of crystallization processes centred around the use of process analytical technology (PAT) is presented and demonstrated on an active pharmaceutical ingredient (API) currently in development at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57d0ee1417719f9e46bca299479ef91a
https://doi.org/10.1021/op0500077
https://doi.org/10.1021/op0500077
Autor:
Melissa Birch
Publikováno v:
The Quarterly Review of Economics and Finance. 38:385-389
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd912f59c6bc0151aa024f0b181520d1
https://doi.org/10.1016/s1062-9769(99)80123-9
https://doi.org/10.1016/s1062-9769(99)80123-9
Autor:
Melissa Birch, Stephen Challenger, Jean-Philippe Crochard, David Fradet, Hayley Jackman, Amy Luan, Evelyn Madigan, Jinu S. Mathew, Neil McDowall, Kevin Meldrum, Charles M. Gordon, Philip Peach, Stephen Yeo
Publikováno v:
Organic Process Research & Development; Nov2011, Vol. 15 Issue 6, p1358-1364, 7p
Publikováno v:
Organic Process Research & Development; Nov2008, Vol. 12 Issue 6, p1104-1113, 10p