Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Melissa Barker"'
Autor:
Samuel N Smukowski, Cassidy Danyko, Jenna Somberg, Eli J Kaufman, Meredith M Course, Nadia Postupna, Melissa Barker-Haliski, C Dirk Keene, Paul N Valdmanis
Publikováno v:
PLoS Genetics, Vol 20, Iss 7, p e1011359 (2024)
Proper transport of RNAs to synapses is essential for localized translation of proteins in response to synaptic signals and synaptic plasticity. Alzheimer's disease (AD) is a neurodegenerative disease characterized by accumulation of amyloid aggregat
Externí odkaz:
https://doaj.org/article/2df89832c2e746d691e31f7e13071a67
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S390-S391 (2023)
Externí odkaz:
https://doaj.org/article/08917fdcac784b308c2f86f254f2410b
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
IntroductionPatients with early-onset Alzheimer's disease (EOAD) experience seizures and subclinical epileptiform activity, which may accelerate cognitive and functional decline. Antiseizure medicines (ASMs) may be a tractable disease-modifying strat
Externí odkaz:
https://doaj.org/article/7698a43fc0b54d18a335440ce55fa5a4
Autor:
Stephanie Mizuno, Zachery Koneval, Dannielle K. Zierath, Kevin M. Knox, H. Steve White, Melissa Barker‐Haliski
Publikováno v:
Epilepsia Open, Vol 6, Iss 2, Pp 431-436 (2021)
Abstract Patients with epilepsy can experience diurnal seizure patterns. However, few studies in rodent models of temporal lobe epilepsy (TLE) routinely quantify the diurnal pattern of spontaneous recurrent seizures (SRS), and those that have conduct
Externí odkaz:
https://doaj.org/article/787f9aad571343788fa66274b7b9515b
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Older people represent the fastest growing group with epilepsy diagnosis. For example, cerebrovascular disease may underlie roughly 30–50% of epilepsy in older adults and seizures are also an underrecognized comorbidity of Alzheimer's disease (AD).
Externí odkaz:
https://doaj.org/article/d32c92afa08a4c62b8b713e7e0408335
Autor:
Megan Beckman, Kevin Knox, Zachery Koneval, Carole Smith, Suman Jayadev, Melissa Barker-Haliski
Publikováno v:
Neurobiology of Disease, Vol 136, Iss , Pp 104719- (2020)
Patients with Alzheimer's disease (AD) experience seizures at higher rates than the general population of that age, suggesting an underexplored role of hyperexcitability in AD. Genetic variants in presenilin (PSEN) 1 and 2 genes lead to autosomal dom
Externí odkaz:
https://doaj.org/article/284c38d1b5284df9a8008e7b75a1fdee
Autor:
Christina A Bormann Chung, Victoria L Boyd, Kevin J McKernan, Yutao Fu, Cinna Monighetti, Heather E Peckham, Melissa Barker
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9320 (2010)
Methylation, the addition of methyl groups to cytosine (C), plays an important role in the regulation of gene expression in both normal and dysfunctional cells. During bisulfite conversion and subsequent PCR amplification, unmethylated Cs are convert
Externí odkaz:
https://doaj.org/article/9fa97e02aa5e4a41980a0662f646573e
Autor:
Melissa Barker-Haliski
Publikováno v:
Handbook of Pediatric Epilepsy Case Studies, Second Edition ISBN: 9781003296478
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd95dabac85afb1f13f4e5e67ac00d09
https://doi.org/10.1201/9781003296478-4
https://doi.org/10.1201/9781003296478-4
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 5
Pages: 4848
Volume 24
Issue 5
Pages: 4848
The mechanisms of treatment-resistant epilepsy remain unclear. We have previously shown that frontline administration of therapeutic doses of lamotrigine (LTG), which preferentially inhibits the fast-inactivation state of sodium channels, during corn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::914d33897bc1bcfc9ca5338c9aecd3f1
https://doi.org/10.20944/preprints202302.0152.v1
https://doi.org/10.20944/preprints202302.0152.v1
Autor:
Aaron del Pozo, Kevin M. Knox, Leanne Lehmann, Stephanie Davidson, Suman Jayadev, Melissa Barker-Haliski
Publikováno v:
bioRxiv
ObjectivePeople with early-onset Alzheimer’s disease (AD) with amyloid precursor protein (APP) duplications or presenilin (PSEN) variants are at elevated seizure risk within 5 years of diagnosis. Further, seizures in AD may increase neuropsychiatri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8266cf185175187b0a01532a65b38365
https://europepmc.org/articles/PMC9881977/
https://europepmc.org/articles/PMC9881977/