Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Melissa A. Vollrath"'
Autor:
Xudong Wu, Artur A Indzhykulian, Paul D Niksch, Roxanna M Webber, Miguel Garcia-Gonzalez, Terry Watnick, Jing Zhou, Melissa A Vollrath, David P Corey
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155577 (2016)
Members of the TRP superfamily of ion channels mediate mechanosensation in some organisms, and have been suggested as candidates for the mechanotransduction channel in vertebrate hair cells. Some TRP channels can be ruled out based on lack of an inne
Externí odkaz:
https://doaj.org/article/b00f9182aaf54875992b113d3ab2035d
Autor:
Melissa A. Vollrath, Elena Cardenas, David P. Corey, Jun Shen, Shuh-Yow Lin, Sara J Mangosing
Publikováno v:
The Journal of Physiology. 594:895-914
Key points The zebrafish pinball wizard (pwi) mutant is deaf and blind. The pwi phenotype includes a reduced auditory startle response and reduced visual evoked potentials, suggesting fatigue of synaptic release at ribbon synapses in hair cells and p
Autor:
Miguel A. Garcia-Gonzalez, Artur A. Indzhykulian, Xudong Wu, Jing Zhou, Melissa A. Vollrath, David P. Corey, Roxanna M. Webber, Terry Watnick, Paul D. Niksch
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 5, p e0155577 (2016)
PLoS ONE, Vol 11, Iss 5, p e0155577 (2016)
Members of the TRP superfamily of ion channels mediate mechanosensation in some organisms, and have been suggested as candidates for the mechanotransduction channel in vertebrate hair cells. Some TRP channels can be ruled out based on lack of an inne
Publikováno v:
Annual Review of Neuroscience. 30:339-365
Mechanical stimuli generated by head movements and changes in sound pressure are detected by hair cells with amazing speed and sensitivity. The mechanosensitive organelle, the hair bundle, is a highly elaborated structure of actin-based stereocilia a
Autor:
Shuh-Yow, Lin, Melissa A, Vollrath, Sara, Mangosing, Jun, Shen, Elena, Cardenas, David P, Corey
Publikováno v:
The Journal of physiology. 594(4)
The zebrafish pinball wizard (pwi) mutant is deaf and blind. The pwi phenotype includes a reduced auditory startle response and reduced visual evoked potentials, suggesting fatigue of synaptic release at ribbon synapses in hair cells and photorecepto
Autor:
Douglas E. Vetter, Philip W. Hinds, Mingqian Huang, Cyrille Sage, David P. Corey, M. Christian Brown, Melissa A. Vollrath, Zheng-Yi Chen
Publikováno v:
Proceedings of the National Academy of Sciences. 103:7345-7350
The retinoblastoma protein pRb is required for cell-cycle exit of embryonic mammalian hair cells but not for their early differentiation. However, its role in postnatal hair cells is unknown. To study the function of pRb in mature animals, we created
Autor:
Melissa A. Vollrath, Clifford J. Woolf, Kelvin Y. Kwan, Andrew Allchorne, David P. Corey, Duan-Sun Zhang, Adam Christensen
Publikováno v:
Neuron. 50(2):277-289
TRPA1, a member of the transient receptor potential (TRP) family of ion channels, is expressed by dorsal root ganglion neurons and by cells of the inner ear, where it has proposed roles in sensing sound, painful cold, and irritating chemicals. To tes
Publikováno v:
Audiology and Neurotology. 7:31-35
Mammalian vestibular afferents respond robustly to head movements at low frequencies and provide input to reflexes that control eye, head and body position. Vestibular organs have distinctive regions and hair cells: Type II cells receive bouton affer
Autor:
Duan Sun Zhang, Jeffrey T. Corwin, David P. Corey, Philip W. Hinds, Cyrille Sage, Zheng-Yi Chen, Jaime García-Añoveros, Mingqian Huang, Kambiz Karimi, Gabriel M. Gutierrez, Melissa A. Vollrath
Publikováno v:
Science (New York, N.Y.). 307(5712)
In mammals, hair cell loss causes irreversible hearing and balance impairment because hair cells are terminally differentiated and do not regenerate spontaneously. By profiling gene expression in developing mouse vestibular organs, we identified the
Autor:
Shuh Yow Lin, Anne Duggan, David P. Corey, Jaime García-Añoveros, Melissa A. Vollrath, Duan Sun Zhang, Bruce Derfler, Eunice L.M. Cheung, Jeffrey R. Holt, Heidi L. Rehm, Kelvin Y. Kwan, Paul A. Gray, Gwenaëlle S. G. Géléoc, Daniel Tamasauskas, Matthew P. Hoffman, Andrea Amalfitano
Publikováno v:
Nature. 432(7018)
Mechanical deflection of the sensory hair bundles of receptor cells in the inner ear causes ion channels located at the tips of the bundle to open, thereby initiating the perception of sound. Although some protein constituents of the transduction app