Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Melissa A. Orr-Asman"'
Autor:
Hala E. Thomas, Jack Rubinstein, Lowell B. Anthony, Carol A. Mercer, Xiaoyang Qi, Kakajan Komurov, David R. Plas, Hanan M. Dahche, Vinicius S. Carreira, Sheryl E. Koch, Kathleen LaSance, Mariah Worley, Min Jiang, Zhengtao Chu, Melissa A. Orr-Asman
Inhibition of mTOR signaling using the rapalog everolimus is an FDA-approved targeted therapy for patients with lung and gastroenteropancreatic neuroendocrine tumors (NET). However, patients eventually progress on treatment, highlighting the need for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64aae7793335e011bc4ba3984f311be0
https://doi.org/10.1158/1535-7163.c.6538789
https://doi.org/10.1158/1535-7163.c.6538789
Autor:
Hala E. Thomas, Jack Rubinstein, Lowell B. Anthony, Carol A. Mercer, Xiaoyang Qi, Kakajan Komurov, David R. Plas, Hanan M. Dahche, Vinicius S. Carreira, Sheryl E. Koch, Kathleen LaSance, Mariah Worley, Min Jiang, Zhengtao Chu, Melissa A. Orr-Asman
Table S1. CC-223-treated mice tend to develop less histopathologic lesions of the heart valves than either rapamycin- or placebo-treated mice. Figure S1. MLN0128 inhibited mTOR signaling in human pNET cell lines in a dose-dependent manner. Figure S2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d90b178ee84c8bf4d1cc19a4cbef7c1
https://doi.org/10.1158/1535-7163.22507783
https://doi.org/10.1158/1535-7163.22507783
Autor:
Emily Igel, Patrick R. Wolfkiel, Anja Jaeschke, David Y. Hui, April Haller, Melissa A. Orr-Asman
Publikováno v:
The Journal of Biological Chemistry
Polymorphisms in the apolipoprotein E (apoE) gene are risk factors for chronic inflammatory diseases including atherosclerosis. The gene product apoE is synthesized in many cell types and has both lipid transport-dependent and lipid transport-indepen
Autor:
Melissa A. Orr-Asman, Xiang Zhang, Scott M. Langevin, Hala Elnakat Thomas, Damaris Kuhnell, Jacek Biesiada, Mario Medvedovic
Publikováno v:
RNA Biology. 16:5-12
Ultracentrifugation remains the gold standard for isolation of small extracellular vesicles (sEV), particularly for cancer applications. The objective of this study was to determine if a widely used ultracentrifugation protocol for isolation of serum
Autor:
Vinicius Carreira, Kakajan Komurov, Lowell Anthony, Min Jiang, Sheryl E. Koch, Zhengtao Chu, Xiaoyang Qi, David R. Plas, Hanan M. Dahche, Carol A. Mercer, Jack Rubinstein, Kathleen LaSance, Hala Elnakat Thomas, Mariah Worley, Melissa A. Orr-Asman
Publikováno v:
Molecular Cancer Therapeutics. 16:2432-2441
Inhibition of mTOR signaling using the rapalog everolimus is an FDA-approved targeted therapy for patients with lung and gastroenteropancreatic neuroendocrine tumors (NET). However, patients eventually progress on treatment, highlighting the need for
Autor:
Nigel Mackman, K. Matiash, Carol A. Mercer, Xiaoyang Qi, Fred V. Lucas, Clayton S. Lewis, Aniruddha Karve, Vladimir Y. Bogdanov, R. E. Boody, H. Elnakat Thomas, Bruce J. Aronow, Melissa A. Orr-Asman, Henri H. Versteeg, H. W. Davis, Yohei Hisada, L. C. Green
Publikováno v:
Journal of Thrombosis and Haemostasis, 17(1), 169-182. WILEY
Essentials Tissue factor (TF) isoforms are expressed in pancreatic neuroendocrine tumors (pNET). TF knockdown inhibits proliferation of human pNET cells in vitro. mTOR kinase inhibitor sapanisertib/MLN0128 suppresses TF expression in human pNET cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ad5073d76a74c15f4a2831fc5d915a
https://europepmc.org/articles/PMC6345540/
https://europepmc.org/articles/PMC6345540/
Autor:
Trisha Wise-Draper, Sarah Palackdharry, Nooshin Hashemi, Vinita Takiar, Benyamin Yaniv, Melissa A. Orr-Asman
Publikováno v:
Clinical Cancer Research. 26:A12-A12
Epidemiologic studies and meta-analyses have indicated that metformin is associated with a lower incidence of tumorigenesis among type 2 diabetic patients, including those with head and neck squamous cell carcinoma (HNSCC). HNSCC patients are often t
Autor:
Chang Xiao, Sally A. Ogle, David J. Robbins, Yana Zavros, Michael A. Schumacher, Robert Tokhunts, Frédéric Hollande, Neal S. Schilling, Melissa A. Orr-Asman, Marian L. Miller
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 299:G1252-G1265
In the stomach, strictly regulated cell adherens junctions are crucial in determining epithelial cell differentiation. Sonic Hedgehog (Shh) regulates epithelial cell differentiation in the adult stomach. We sought to identify whether Shh plays a role
Autor:
Sally A. Ogle, Chang Xiao, Michael A. Schumacher, Nantaporn Lertkowit, Andrea Varro, Frédéric Hollande, Melissa A. Orr–Asman, Marian L. Miller, Yana Zavros
Publikováno v:
Gastroenterology. 138:550-561.e8
Background & Aims Sonic Hedgehog (Shh) is expressed in the adult stomach, but its role as a gastric morphogen is unclear. We sought to identify mechanisms by which Shh might regulate gastric epithelial cell function and differentiation. Methods Mice