Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Melissa A. Luse"'
Autor:
Claire A. Ruddiman, Richard Peckham, Melissa A. Luse, Yen-Lin Chen, Maniselvan Kuppusamy, Bruce A. Corliss, P. Jordan Hall, Chien-Jung Lin, Shayn M. Peirce, Swapnil K. Sonkusare, Robert P. Mecham, Jessica E. Wagenseil, Brant E. Isakson
Publikováno v:
JCI Insight, Vol 8, Iss 9 (2023)
Lipid regulation of ion channels is largely explored using in silico modeling with minimal experimentation in intact tissue; thus, the functional consequences of these predicted lipid-channel interactions within native cellular environments remain el
Externí odkaz:
https://doaj.org/article/7e3053ea3fba4f4ebcd0e85d89274a84
Autor:
Tristan J. Ragland, Emily M. Heiston, Anna Ballantyne, Nathan R. Stewart, Sabrina La Salvia, Luca Musante, Melissa A. Luse, Brant E. Isakson, Uta Erdbrügger, Steven K. Malin
Publikováno v:
Physiological Reports, Vol 11, Iss 1, Pp n/a-n/a (2023)
Abstract Metabolic Syndrome (MetS) raises cardiovascular disease risk. Extracellular vesicles (EVs) have emerged as important mediators of insulin sensitivity, although few studies on vascular function exist in humans. We determined the effect of ins
Externí odkaz:
https://doaj.org/article/09efe118087d451c8c600c93d7f901af
Autor:
Mitchell E. Granade, Stefan R. Hargett, Daniel S. Lank, Michael C. Lemke, Melissa A. Luse, Brant E. Isakson, Irina M. Bochkis, Joel Linden, Thurl E. Harris
Publikováno v:
Molecular Metabolism, Vol 63, Iss , Pp 101543- (2022)
Objective: Adipose tissue is a critical regulator of energy balance that must rapidly shift its metabolism between fasting and feeding to maintain homeostasis. Adenosine has been characterized as an important regulator of adipocyte metabolism primari
Externí odkaz:
https://doaj.org/article/4d0f181c11f14a62817560bbc6f02485
Autor:
Syed S. Hussain, Tuyet-Minh Tran, Timothy B. Ware, Melissa A. Luse, Christopher T. Prevost, Ashley N. Ferguson, Jennifer A. Kashatus, Ku-Lung Hsu, David F. Kashatus
Publikováno v:
Cell Reports, Vol 36, Iss 4, Pp 109451- (2021)
Summary: Lipid droplets (LDs) are dynamic organelles that undergo dynamic changes in response to changing cellular conditions. During nutrient depletion, LD numbers increase to protect cells against toxic fatty acids generated through autophagy and p
Externí odkaz:
https://doaj.org/article/7d1ca44d34e043e18caedbea8c3d9b61
Vascular networks are critical to the survival of cells within materials designed for regenerative medicine. Developing approaches to vascularize three-dimensional (3D)in vitromodels that recreate tissue physiology and 3D tissue constructs for regene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d99cfaec408ecb7f583aaf3610df87cb
https://doi.org/10.1101/2023.03.15.532817
https://doi.org/10.1101/2023.03.15.532817
Autor:
Tristan J. Ragland, Emily M. Heiston, Anna Ballantyne, Nathan R. Stewart, Sabrina La Salvia, Luca Musante, Melissa A. Luse, Brant E. Isakson, Uta Erdbrügger, Steven K. Malin
Publikováno v:
Physiological reportsREFERENCES. 11(1)
Metabolic Syndrome (MetS) raises cardiovascular disease risk. Extracellular vesicles (EVs) have emerged as important mediators of insulin sensitivity, although few studies on vascular function exist in humans. We determined the effect of insulin on E
Autor:
Claire A. Ruddiman, Richard Peckham, Melissa A. Luse, Yen-Lin Chen, Maniselvan Kuppusamy, Bruce Corliss, P. Jordan Hall, Chien-Jung Lin, Shayn M Peirce, Swapnil K. Sonkusare, Robert P. Mecham, Jessica E. Wagenseil, Brant E. Isakson
In the resistance artery endothelium, we show phosphatidylserine (PS) localizes to a specific subpopulation of myoendothelial junctions (MEJs), signaling microdomains that regulate vasodilation. In silico data has implied PS may compete with PIP2 bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84ee9347786ed1e5f2d78ab1a3e22678
https://doi.org/10.1101/2022.08.01.502310
https://doi.org/10.1101/2022.08.01.502310
Autor:
Abigail G. Wolpe, Melissa A. Luse, Scott R. Johnstone, Jianxiang Xue, Vikram Sabapathy, Brent Wakefield, Rahul Sharma, Kevin Barr, Frank Beier, Dale Laird, Stefanie Redemann, Linda Columbus, Silvia Penuela, Brant E. Isakson
Publikováno v:
Paediatrics Publications
Pannexin channel isoforms (Panx1-3) are thought to release nucleotides into the extracellular milieu and have been shown to effect vascular hemodynamics. For this reason, we examined their mRNA and protein expression in hypertensive humans and geneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35de790385b481a395b6d6aecddd2669
https://ir.lib.uwo.ca/paedpub/762
https://ir.lib.uwo.ca/paedpub/762
Autor:
Melissa A. Luse, Caitlin Pavelic, Rachael Tessema, Jesse Cochran, Richard D. Minshall, Norbert Leitinger, Brant E. Isakson
Publikováno v:
The FASEB Journal. 36
Publikováno v:
Curr Pharm Des
Endothelial dysfunction is a hallmark of type 2 diabetes that can have severe consequences on vascular function, including hypertension and changes in blood flow, as well as exercise performance. Because endothelium is also the barrier for insulin mo