Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Melissa A. Harrison"'
Autor:
Arjun Rajan, Lucas Anhezini, Noemi Rives-Quinto, Jay Y Chhabra, Megan C Neville, Elizabeth D Larson, Stephen F Goodwin, Melissa M Harrison, Cheng-Yu Lee
Publikováno v:
eLife, Vol 12 (2023)
Coordinated regulation of gene activity by transcriptional and translational mechanisms poise stem cells for a timely cell-state transition during differentiation. Although important for all stemness-to-differentiation transitions, mechanistic unders
Externí odkaz:
https://doaj.org/article/66c1d0c26bf94422a25197895b76c7fa
Autor:
Maëlle Bellec, Jérémy Dufourt, George Hunt, Hélène Lenden-Hasse, Antonio Trullo, Amal Zine El Aabidine, Marie Lamarque, Marissa M. Gaskill, Heloïse Faure-Gautron, Mattias Mannervik, Melissa M. Harrison, Jean-Christophe Andrau, Cyril Favard, Ovidiu Radulescu, Mounia Lagha
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Using quantitative imaging and monitoring transcription in living embryos, Bellec et al., provide evidence that the pioneer factor GAF acts as a stable mitotic bookmarker during early Drosophila development.
Externí odkaz:
https://doaj.org/article/80b25a724980469e83291c0573c05048
Autor:
Elizabeth D. Larson, Hideyuki Komori, Tyler J. Gibson, Cyrina M. Ostgaard, Danielle C. Hamm, Jack M. Schnell, Cheng-Yu Lee, Melissa M. Harrison
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The pioneer transcription factor Zelda is essential for the reprogramming of germ cells to totipotent cells of the early Drosophila embryo. Here the authors examine the function of Zelda later in development in the larval brain to show that Zelda pro
Externí odkaz:
https://doaj.org/article/7880554850f74ce895ae871ea6535462
Publikováno v:
eLife, Vol 10 (2021)
Following fertilization, the genomes of the germ cells are reprogrammed to form the totipotent embryo. Pioneer transcription factors are essential for remodeling the chromatin and driving the initial wave of zygotic gene expression. In Drosophila mel
Externí odkaz:
https://doaj.org/article/934df474a8e741bcb8e2dcf80fed6838
Autor:
Jeremy Dufourt, Antonio Trullo, Jennifer Hunter, Carola Fernandez, Jorge Lazaro, Matthieu Dejean, Lucas Morales, Saida Nait-Amer, Katharine N. Schulz, Melissa M. Harrison, Cyril Favard, Ovidiu Radulescu, Mounia Lagha
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Zelda is a pioneer factor that regulates transcription in Drosophila embryos. Here, the authors use quantitative live imaging and mathematical modeling to measure the effect of Zelda on transcriptional dynamics and memory, observing temporal control
Externí odkaz:
https://doaj.org/article/6f73d116eb0e46649c4a65fbc2648168
Autor:
Tyler J. Gibson, Melissa M. Harrison
Chromatin is a barrier to the binding of many transcription factors. By contrast, pioneer factors access nucleosomal targets and promote chromatin opening. Despite binding to target motifs in closed chromatin, many pioneer factors display cell-type s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17f82d81b4f9c0749f79c45b83520e12
https://doi.org/10.1101/2023.03.18.533281
https://doi.org/10.1101/2023.03.18.533281
Autor:
Danielle C. Hamm, Melissa M. Harrison
Publikováno v:
Open Biology, Vol 8, Iss 12 (2018)
The onset of metazoan development requires that two terminally differentiated germ cells, a sperm and an oocyte, become reprogrammed to the totipotent embryo, which can subsequently give rise to all the cell types of the adult organism. In nearly all
Externí odkaz:
https://doaj.org/article/2538b294757f4e4ba483a2f863578003
Autor:
Mustafa Mir, Michael R Stadler, Stephan A Ortiz, Colleen E Hannon, Melissa M Harrison, Xavier Darzacq, Michael B Eisen
Publikováno v:
eLife, Vol 7 (2018)
The regulation of transcription requires the coordination of numerous activities on DNA, yet how transcription factors mediate these activities remains poorly understood. Here, we use lattice light-sheet microscopy to integrate single-molecule and hi
Externí odkaz:
https://doaj.org/article/514a34db9a2148df837e79a3f9950057
Autor:
Ostgaard Cm, Hamm Dc, Choul-Gyun Lee, Schnell Jm, Tyler J. Gibson, Elizabeth D. Larson, Hideyuki Komori, Melissa M. Harrison
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
During Drosophila embryogenesis, the essential pioneer factor Zelda defines hundreds of cis-regulatory regions and in doing so reprograms the zygotic transcriptome. While Zelda is essential later in development, it is unclear how the ability of Zelda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cff74791fd570b7710cf0fd5ea3b13e
https://doaj.org/article/7880554850f74ce895ae871ea6535462
https://doaj.org/article/7880554850f74ce895ae871ea6535462
Autor:
Marissa. M. Gaskill, Isabella V. Soluri, Annemarie E. Branks, Alan P. Boka, Michael R. Stadler, Katherine Vietor, Hao-Yu S. Huang, Tyler J. Gibson, Mustafa Mir, Shelby A. Blythe, Melissa M. Harrison
/SummaryThe eukaryotic genome is organized to enable the precise regulation of gene expression required for development. This organization is established during early development when the embryo transitions from a fertilized germ cell to the totipote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f3267f26c9efa30151a8e471cae5ccc
https://doi.org/10.1101/2022.11.29.518380
https://doi.org/10.1101/2022.11.29.518380