Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Melissa A. Farrow"'
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
Alzheimer’s disease (AD) is the most common form of neurological dementia, specified by extracellular β-amyloid plaque deposition, neurofibrillary tangles, and cognitive impairment. AD-associated pathologies like cerebral amyloid angiopathy (CAA)
Externí odkaz:
https://doaj.org/article/ba09651be18f4ca2ae9a096431e12fcc
Autor:
James C. Pino, Alexander L.R. Lubbock, Leonard A. Harris, Danielle B. Gutierrez, Melissa A. Farrow, Nicole Muszynski, Tina Tsui, Stacy D. Sherrod, Jeremy L. Norris, John A. McLean, Richard M. Caprioli, John P. Wikswo, Carlos F. Lopez
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105341- (2022)
Summary: Technological advances have made it feasible to collect multi-condition multi-omic time courses of cellular response to perturbation, but the complexity of these datasets impedes discovery due to challenges in data management, analysis, visu
Externí odkaz:
https://doaj.org/article/db35e3c9ebe3431c98e583179d280a79
Correction: Toxin B Causes Epithelial Cell Necrosis through an Autoprocessing-Independent Mechanism.
Autor:
Nicole M. Chumbler, Melissa A. Farrow, Lynne A. Lapierre, Jeffrey L. Franklin, David B. Haslam, James R. Goldenring, D. Borden Lacy
Publikováno v:
PLoS Pathogens, Vol 8, Iss 12 (2012)
Externí odkaz:
https://doaj.org/article/0fd4bb42eafe44d385a99a4cc0a41aec
Autor:
Elizabeth K. Neumann, Nathan Heath Patterson, Leonoor E.M. Tideman, Lukasz G. Migas, Madeline E. Colley, Melissa A. Farrow, Jamie L. Allen, Emilio S. Rivera, Carrie E. Romer, Haichun Yang, Maya Brewer, Kavya Sharman, Raymond C. Harris, Agnes B. Fogo, Danielle B. Gutierrez, Mark P. de Caestecker, Richard M. Caprioli, Raf Van de Plas, Jeffrey M. Spraggins
SummaryThe human kidney is composed of over 26 cell types that actively coordinate with each other to form higher-order structures, such as the nephron. It is not yet understood how these structures vary throughout a single organ or amongst the same
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::633e7304214faa7ad39eae8530ef1c1f
https://doi.org/10.1101/2022.04.07.487155
https://doi.org/10.1101/2022.04.07.487155
Autor:
Alexander L. R. Lubbock, Leonard A. Harris, Jeremy L. Norris, James C. Pino, Carlos F. Lopez, Richard M. Caprioli, Danielle B. Gutierrez, John P. Wikswo, Melissa A. Farrow, Nicole D. Muszynski, Tina Tsui
Recent technological advances have made it feasible to collect multi-condition transcriptome and proteome time-courses of cellular response to perturbation. The increasing size and complexity of these datasets impedes mechanism of action discovery du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669984c73d9ee3f28fba19dda5f29882
https://doi.org/10.1101/2020.03.02.974121
https://doi.org/10.1101/2020.03.02.974121
Autor:
McKenzie King, Melissa A. Farrow, Benjamin W. Spiller, John A. Shupe, Sarah C. Bloch, Kaycei Moton-Melancon, Nicole M. Chumber, D. Borden Lacy, Mary Kay Washington
Publikováno v:
ACS Chem Biol
Clostridioides difficile is the leading cause of nosocomial diarrhea in the United States. The primary virulence factors are two homologous sglucosyltransferase toxins, TcdA and TcdB, that inactivate host Rho-family GTPases. The glucosyltransferase a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc73c87bf52e2809cf36861a6dc889f9
https://europepmc.org/articles/PMC7230009/
https://europepmc.org/articles/PMC7230009/
Autor:
William J. Burns, Melissa A. Farrow, Lauren D. Palmer, Richard M. Caprioli, John A. McLean, Ashley T Jordan, Yuan-Wei Nei, K. Nichole Maloney, D. Borden Lacy, Jeremy L. Norris, Randi L. Gant-Branum, William N. Beavers, Tina Tsui, Jamie L. Allen, Eric P. Skaar, Danielle B. Gutierrez, Stacy D. Sherrod, Carrie E Romer
Publikováno v:
Metallomics
Zinc (Zn) is an essential trace metal required for all forms of life, but is toxic at high concentrations. While the toxic effects of high levels of Zn are well documented, the mechanism of cell death appears to vary based on the study and concentrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23bb7a9280ea7b398efa48ea68d0d7c5
https://europepmc.org/articles/PMC6531343/
https://europepmc.org/articles/PMC6531343/
Autor:
Stacy D. Sherrod, Richard M. Caprioli, John A. McLean, Ashley T Jordan, Randi L. Gant-Branum, Lauren D. Palmer, Melissa A. Farrow, Jeremy L. Norris, Danielle B. Gutierrez, Yuan-Wei Nei, Carrie E Romer, Simona G. Codreanu, Eric P. Skaar, Nikesh Dahal, Jamie L. Allen
Publikováno v:
Journal of proteome research. 17(10)
Proteomics, metabolomics, and transcriptomics generate comprehensive data sets, and current biocomputational capabilities allow their efficient integration for systems biology analysis. Published multiomics studies cover methodological advances as we
Autor:
D. Borden Lacy, Donald H. Rubin, Ramyavardhanee Chandrasekaran, Michelle E. LaFrance, Melissa A. Farrow, Jinsong Sheng
Publikováno v:
Proceedings of the National Academy of Sciences. 112:7073-7078
Clostridium difficile is the leading cause of hospital-acquired diarrhea in the United States. The two main virulence factors of C. difficile are the large toxins, TcdA and TcdB, which enter colonic epithelial cells and cause fluid secretion, inflamm
Autor:
Stacey A. Rutherford, James R. Goldenring, Nicole M. Chumbler, Jeffrey L. Franklin, Lynne A. Lapierre, D. Borden Lacy, Melissa A. Farrow
Publikováno v:
Proceedings of the National Academy of Sciences. 110:18674-18679
Clostridium difficile infection (CDI) is a leading cause of health care-associated diarrhea and has increased in incidence and severity over the last decade. Pathogenesis is mediated by two toxins, TcdA and TcdB, which cause fluid secretion, inflamma