Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Melissa A Fath"'
Autor:
Kyle C Kloepping, Alora S Kraus, Devin K Hedlund, Colette M Gnade, Brett A Wagner, Michael L McCormick, Melissa A Fath, Dongrim Seol, Tae-Hong Lim, Garry R Buettner, Prabhat C Goswami, F Christopher Pigge, Douglas R Spitz, Michael K Schultz
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244540 (2020)
Despite dramatic improvements in outcomes arising from the introduction of targeted therapies and immunotherapies, metastatic melanoma is a highly resistant form of cancer with 5 year survival rates of
Externí odkaz:
https://doaj.org/article/8a2fd83c241244dfa3511b930ade9fd2
Autor:
Spenser S. Johnson, Dijie Liu, Jordan T. Ewald, Claudia Robles-Planells, Casey Pulliam, Keegan A. Christensen, Khaliunaa Bayanbold, Brian R. Wels, Shane R. Solst, M. Sue O’Dorisio, Yusuf Menda, Douglas R. Spitz, Melissa A. Fath
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
Thioredoxin Reductase (TrxR) functions to recycle thioredoxin (Trx) during hydroperoxide metabolism mediated by peroxiredoxins and is currently being targeted using the FDA-approved anti-rheumatic drug, auranofin (AF), to selectively sensitize cancer
Externí odkaz:
https://doaj.org/article/c5a3742216384e1498585e82c931ad1b
Autor:
Mekhla Singhania, Amira Zaher, Casey F. Pulliam, Khaliunaa Bayanbold, Charles C. Searby, Joshua D. Schoenfeld, Kranti A. Mapuskar, Melissa A. Fath, Bryan G. Allen, Douglas R. Spitz, Michael S. Petronek
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2398 (2024)
Cancer cells frequently present elevated intracellular iron levels, which are thought to facilitate an enhanced proliferative capacity. Targeting iron metabolism within cancer cells presents an avenue to enhance therapeutic responses, necessitating t
Externí odkaz:
https://doaj.org/article/226bada5cf3345548216f30713cfa0e3
Autor:
Kristin E. Brandt, Kelly C. Falls, Joshua D. Schoenfeld, Samuel N. Rodman, Zhimin Gu, Fenghuang Zhan, Joseph J. Cullen, Brett A. Wagner, Garry R. Buettner, Bryan G. Allen, Daniel J. Berg, Douglas R. Spitz, Melissa A. Fath
Publikováno v:
Redox Biology, Vol 14, Iss , Pp 82-87 (2018)
Pharmacological doses (> 1Â mM) of ascorbate (a.k.a., vitamin C) have been shown to selectively kill cancer cells through a mechanism that is dependent on the generation of H2O2 at doses that are safely achievable in humans using intravenous adminis
Externí odkaz:
https://doaj.org/article/959fae2b285c4504aa4c9bdc7bfe028d
Autor:
Margaret L. Musser, Alyssa L. Mahaffey, Melissa A. Fath, Garry R. Buettner, Brett A. Wagner, Benjamin K. Schneider, Yeon-Jung Seo, Jonathan P. Mochel, Chad M. Johannes
Publikováno v:
Frontiers in Veterinary Science, Vol 6 (2019)
Background: High-dose, pharmacological ascorbate (P-AscH−) is preferentially cytotoxic to human cancer cells in vitro. Investigations on the efficacy of P-AscH− as an adjuvant treatment for multiple human cancers are on-going, but has yet to be f
Externí odkaz:
https://doaj.org/article/b8897e984f134104ace17fbd27f676f2
Autor:
Spenser S. Johnson, Dijie Liu, Jordan T. Ewald, Claudia Robles-Planells, Khaliunaa Bayanbold, Brian R. Wels, Shane R. Solst, M. Sue O’Dorisio, Bryan G. Allen, Yusuf Menda, Douglas R. Spitz, Melissa A. Fath
Publikováno v:
bioRxiv
Thioredoxin Reductase (TrxR) is a key enzyme in reactive oxygen species (ROS) detoxification and in redox regulation. Because cancer cells produce increased steady-state levels of ROS (i.e., superoxide and hydrogen peroxide), TrxR is viable target in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db2b29a43eee17c37e62aa5bb71f97e
https://doi.org/10.1101/2023.05.07.539772
https://doi.org/10.1101/2023.05.07.539772
Autor:
James J. Mezhir, Douglas R. Spitz, Frederick E. Domann, Michael D. Henry, Jeffery Keene, Robert A. Beardsley, Wendy Cozen, Brenda Y. Hernandez, Charles F. Lynch, Garry R. Buettner, Brett A. Wagner, Sean Altekruse, Adam J. Case, Bryan G. Allen, Anna M. Button, Jennifer E. Hrabe, Andrew M. Bellizzi, Melissa A. Fath, Brianne R. O'Leary
Purpose: Pancreatic ductal adenocarcinoma (PDA) cells are known to produce excessive amounts of reactive oxygen species (ROS), particularly superoxide, which may contribute to the aggressive and refractory nature of this disease. Extracellular supero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eae4856d3131fd3f32d129a044172b5
https://doi.org/10.1158/1078-0432.c.6524636
https://doi.org/10.1158/1078-0432.c.6524636
Purpose: Cancer cells (relative to normal cells) show increased steady-state levels of hydroperoxides that are compensated by increased glucose and hydroperoxide metabolism. The current study determined whether inhibitors of glucose and hydroperoxide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2c10a1416779cf0d9bca5c7003f316
https://doi.org/10.1158/1078-0432.c.6519573
https://doi.org/10.1158/1078-0432.c.6519573
Autor:
James J. Mezhir, Douglas R. Spitz, Frederick E. Domann, Michael D. Henry, Jeffery Keene, Robert A. Beardsley, Wendy Cozen, Brenda Y. Hernandez, Charles F. Lynch, Garry R. Buettner, Brett A. Wagner, Sean Altekruse, Adam J. Case, Bryan G. Allen, Anna M. Button, Jennifer E. Hrabe, Andrew M. Bellizzi, Melissa A. Fath, Brianne R. O'Leary
Supplementary Figures 1-3. S1: Creation and characterization of EcSOD stably expressing PDA cell lines.; S2: Activity of EcSOD activity from stably expression PDA cell lines; S3: L-NNA decreases NOS activity in PDA cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63919690b745739c526d32753ff4044
https://doi.org/10.1158/1078-0432.22460894
https://doi.org/10.1158/1078-0432.22460894
Autor:
James J. Mezhir, Douglas R. Spitz, Frederick E. Domann, Michael D. Henry, Jeffery Keene, Robert A. Beardsley, Wendy Cozen, Brenda Y. Hernandez, Charles F. Lynch, Garry R. Buettner, Brett A. Wagner, Sean Altekruse, Adam J. Case, Bryan G. Allen, Anna M. Button, Jennifer E. Hrabe, Andrew M. Bellizzi, Melissa A. Fath, Brianne R. O'Leary
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0839672d2a866796c26d91cc01f2ac59
https://doi.org/10.1158/1078-0432.22460897
https://doi.org/10.1158/1078-0432.22460897