Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Melissa A Edeling"'
Autor:
Melissa A Edeling, S Kyle Austin, Bimmi Shrestha, Kimberly A Dowd, Swati Mukherjee, Christopher A Nelson, Syd Johnson, Manu N Mabila, Elizabeth A Christian, Joseph Rucker, Theodore C Pierson, Michael S Diamond, Daved H Fremont
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1004072 (2014)
We recently described our most potently neutralizing monoclonal antibody, E106, which protected against lethal Dengue virus type 1 (DENV-1) infection in mice. To further understand its functional properties, we determined the crystal structure of E10
Externí odkaz:
https://doaj.org/article/2e886409b57a4c2e80d053bbf06bccf9
Autor:
Julio Carrera Montoya, Simon Collett, Daniel Fernandez Ruiz, Linda Earnest, Melissa A. Edeling, Ashley Huey Yiing Yap, Chinn Yi Wong, James P. Cooney, Kathryn C. Davidson, Jason Roberts, Steven Rockman, Bang M. Tran, Julie L. McAuley, Georgia Deliyannis, Samantha L. Grimley, Damian F. J. Purcell, Shafagh A. Waters, Dale I. Godfrey, Dhiraj Hans, Marc Pellegrini, Jason M. Mackenzie, Elizabeth Vincan, William R. Heath, Joseph Torresi
Publikováno v:
Organoids, Vol 3, Iss 1, Pp 18-31 (2024)
Existing mRNA COVID-19 vaccines have shown efficacy in reducing severe cases and fatalities. However, their effectiveness against infection caused by emerging SARS-CoV-2 variants has waned considerably, necessitating the development of variant vaccin
Externí odkaz:
https://doaj.org/article/cf1701857c3e4eef8731f1d72ff37ded
Autor:
Pankaj Pal, Kimberly A Dowd, James D Brien, Melissa A Edeling, Sergey Gorlatov, Syd Johnson, Iris Lee, Wataru Akahata, Gary J Nabel, Mareike K S Richter, Jolanda M Smit, Daved H Fremont, Theodore C Pierson, Mark T Heise, Michael S Diamond
Publikováno v:
PLoS Pathogens, Vol 9, Iss 4, p e1003312 (2013)
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes global epidemics of a debilitating polyarthritis in humans. As there is a pressing need for the development of therapeutic agents, we screened 230 new mouse anti-CHIKV monoclo
Externí odkaz:
https://doaj.org/article/ff8cc6d219204c04bb30a4d8c649dab2
Autor:
S Kyle Austin, Kimberly A Dowd, Bimmi Shrestha, Christopher A Nelson, Melissa A Edeling, Syd Johnson, Theodore C Pierson, Michael S Diamond, Daved H Fremont
Publikováno v:
PLoS Pathogens, Vol 8, Iss 10, p e1002930 (2012)
We previously developed a panel of neutralizing monoclonal antibodies against Dengue virus (DENV)-1, of which few exhibited inhibitory activity against all DENV-1 genotypes. This finding is consistent with reports observing variable neutralization of
Externí odkaz:
https://doaj.org/article/1b208d14ff4c44678b1d5ccad2b34bc2
Autor:
Bimmi Shrestha, James D Brien, Soila Sukupolvi-Petty, S Kyle Austin, Melissa A Edeling, Taekyung Kim, Katie M O'Brien, Christopher A Nelson, Syd Johnson, Daved H Fremont, Michael S Diamond
Publikováno v:
PLoS Pathogens, Vol 6, Iss 4, p e1000823 (2010)
Antibody protection against flaviviruses is associated with the development of neutralizing antibodies against the viral envelope (E) protein. Prior studies with West Nile virus (WNV) identified therapeutic mouse and human monoclonal antibodies (MAbs
Externí odkaz:
https://doaj.org/article/df704f99bc524bef9b9a3a5bc6a7a1a1
Autor:
Melissa A Edeling, Subramaniam Sanker, Takaki Shima, P K Umasankar, Stefan Höning, Hye Y Kim, Lance A Davidson, Simon C Watkins, Michael Tsang, David J Owen, Linton M Traub
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8150 (2009)
PACSIN/Syndapin proteins are membrane-active scaffolds that participate in endocytosis. The structure of the Drosophila Syndapin N-terminal EFC domain reveals a crescent shaped antiparallel dimer with a high affinity for phosphoinositides and a uniqu
Externí odkaz:
https://doaj.org/article/338ea4edadf24b37899b08ee82ff5476
Autor:
Simon Collett, Linda Earnest, Julio Carrera Montoya, Melissa A. Edeling, Ashley Yap, Chinn Yi Wong, Dale Christiansen, Jason Roberts, Jamie Mumford, Valerie Lecouturier, Vincent Pavot, Sergio Marco, Joon Keit Loi, Cameron Simmons, Shivali A. Gulab, Jason M. Mackenzie, Aaron Elbourne, Paul A. Ramsland, Garth Cameron, Dhiraj Hans, Dale I. Godfrey, Joseph Torresi
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
The development of virus-like particle (VLP) based vaccines for human papillomavirus, hepatitis B and hepatitis E viruses represented a breakthrough in vaccine development. However, for dengue and COVID-19, technical complications, such as an incompl
Externí odkaz:
https://doaj.org/article/db5da8de105e44ddb37fe0edcbcb6989
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Our understanding of the immune responses that follow SARS-CoV-2 infection and vaccination has progressed considerably since the COVID-19 pandemic was first declared on the 11th of March in 2020. Recovery from infection is associated with the develop
Externí odkaz:
https://doaj.org/article/1a55759b1b18465d884bc8ed38a3d2c8
Autor:
Robyn S. Klein, Kristen E. Funk, Janet L. Smith, Christina R. DeMaso, Eva Harris, Theodore C. Pierson, Thu Minh Cao, Daved H. Fremont, Kimberly A. Dowd, Melissa A. Edeling, Alex W. Wessel, Christopher A. Nelson, Michael S. Diamond, Ping Zhang, Scott B. Biering, Richard J. Kuhn
Publikováno v:
J Virol
Dengue virus (DENV) and West Nile virus (WNV) are arthropod-transmitted flaviviruses that cause systemic vascular leakage and encephalitis syndromes, respectively, in humans. However, the viral factors contributing to these specific clinical disorder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f37a0e091b0e907991513bde1bc12a3
https://europepmc.org/articles/PMC8475509/
https://europepmc.org/articles/PMC8475509/
Autor:
David H. Fremont, Michael S. Diamond, Gavin R. Screaton, Vicky Roy, Christopher A. Nelson, Juthathip Mongkolsapaya, Robin G. Bombardi, Melissa A. Edeling, Irene Bosch, James E. Crowe, Galit Alter, Nurgun Kose, Warangkana Chantima, Alex W. Wessel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
There are no licensed therapeutics or vaccines available against Zika virus (ZIKV) to counteract its potential for congenital disease. Antibody-based countermeasures targeting the ZIKV envelope protein have been hampered by concerns for cross-reactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92a94c39129f54d34e252f428bbc83d
https://doi.org/10.1038/s41467-020-19096-y
https://doi.org/10.1038/s41467-020-19096-y