Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Melissa A Chiasson"'
Autor:
Melissa A Chiasson, Nathan J Rollins, Jason J Stephany, Katherine A Sitko, Kenneth A Matreyek, Marta Verby, Song Sun, Frederick P Roth, Daniel DeSloover, Debora S Marks, Allan E Rettie, Douglas M Fowler
Publikováno v:
eLife, Vol 9 (2020)
Vitamin K epoxide reductase (VKOR) drives the vitamin K cycle, activating vitamin K-dependent blood clotting factors. VKOR is also the target of the widely used anticoagulant drug, warfarin. Despite VKOR’s pivotal role in coagulation, its structure
Externí odkaz:
https://doaj.org/article/36b421f0fd264b0f97e516ab449e0b61
Autor:
Carl Song, Melissa A Chiasson, Nirvana Nursimulu, Stacy S Hung, James Wasmuth, Michael E Grigg, John Parkinson
Publikováno v:
Molecular Systems Biology, Vol 9, Iss 1, Pp 1-17 (2013)
Abstract Increasingly, metabolic potential is proving to be a critical determinant governing a pathogen's virulence as well as its capacity to expand its host range. To understand the potential contribution of metabolism to strain‐specific infectiv
Externí odkaz:
https://doaj.org/article/5d7e5232705a457795b7c97a57ac970f
Autor:
Katherine A. Sitko, Lai Hong Wong, Allan E. Rettie, Gabriel Boyle, Clara J. Amorosi, John P. Kowalski, Melissa A Chiasson, Douglas M. Fowler, Maitreya J. Dunham, Matthew G. McDonald
Publikováno v:
Am J Hum Genet
CYP2C9 encodes a cytochrome P450 enzyme responsible for metabolizing up to 15% of small molecule drugs, and CYP2C9 variants can alter the safety and efficacy of these therapeutics. In particular, the anti-coagulant warfarin is prescribed to over 15 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246f02008e4beb6e3257ac1171b8faf7
https://doi.org/10.1016/j.ajhg.2021.07.001
https://doi.org/10.1016/j.ajhg.2021.07.001
Autor:
Tomasz Blazejewski, Nirvana Nursimulu, Viviana Pszenny, Sriveny Dangoudoubiyam, Sivaranjani Namasivayam, Melissa A. Chiasson, Kyle Chessman, Michelle Tonkin, Lakshmipuram S. Swapna, Stacy S. Hung, Joshua Bridgers, Stacy M. Ricklefs, Martin J. Boulanger, Jitender P. Dubey, Stephen F. Porcella, Jessica C. Kissinger, Daniel K. Howe, Michael E. Grigg, John Parkinson
Publikováno v:
mBio, Vol 6, Iss 1 (2015)
ABSTRACT Sarcocystis neurona is a member of the coccidia, a clade of single-celled parasites of medical and veterinary importance including Eimeria, Sarcocystis, Neospora, and Toxoplasma. Unlike Eimeria, a single-host enteric pathogen, Sarcocystis, N
Externí odkaz:
https://doaj.org/article/1b21fff66b5144da8b40c3091910cd88
Publikováno v:
Clin Pharmacol Ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6143193775e28d0f1e7760dd6bd4cac
https://doi.org/10.1002/cpt.1468
https://doi.org/10.1002/cpt.1468
Autor:
Allan E. Rettie, Song Sun, Daniel DeSloover, Marta Verby, Frederick P. Roth, Katherine A. Sitko, Kenneth A. Matreyek, Nathan J Rollins, Jason J. Stephany, Melissa A Chiasson, Douglas M. Fowler, Debora S. Marks
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Vitamin K epoxide reductase (VKOR) drives the vitamin K cycle, activating vitamin K-dependent blood clotting factors. VKOR is also the target of the widely used anticoagulant drug, warfarin Despite VKOR’s pivotal role in coagulation, its structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1088afa0a0b15228fe6a7d65454e593c
https://doi.org/10.7554/elife.58026
https://doi.org/10.7554/elife.58026
Autor:
Song Sun, Kenneth A. Matreyek, Jason J. Stephany, Debora S. Marks, Marta Verby, Katherine A. Sitko, Nathan J Rollins, Melissa A Chiasson, Douglas M. Fowler, Frederick P. Roth, Allan E. Rettie, Daniel DeSloover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0983df6698d5f69329d155f48c9f1bb1
https://doi.org/10.7554/elife.58026.sa2
https://doi.org/10.7554/elife.58026.sa2
Autor:
Kenneth A. Matreyek, Douglas M. Fowler, Nicholas Hasle, Melissa A Chiasson, Jason J. Stephany
Publikováno v:
Nucleic Acids Research
Multiplex genetic assays can simultaneously test thousands of genetic variants for a property of interest. However, limitations of existing multiplex assay methods in cultured mammalian cells hinder the breadth, speed and scale of these experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278bfcf663874293feffe57620961d3c
https://doi.org/10.1093/nar/gkz910
https://doi.org/10.1093/nar/gkz910
Autor:
Jennifer N. Dines, Martin Kircher, William E. Evans, Douglas M. Fowler, Wenjian Yang, Smita Bhatia, Ronald J. Hause, Jay Shendure, Beth Martin, Kenneth A. Matreyek, Mary V. Relling, Vanessa E. Gray, Jason J. Stephany, Arineh Khechaduri, Melissa A Chiasson, Lea M. Starita
Publikováno v:
Nature genetics
Determining the pathogenicity of human genetic variants is a critical challenge, and functional assessment is often the only option. Experimentally characterizing millions of possible missense variants in thousands of clinically important genes will
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::994b60fa749c7a52249d03e6dada223e
https://doi.org/10.1101/211011
https://doi.org/10.1101/211011
Autor:
Melissa A. Chiasson, Rubens Belfort, Natarajan Sundar, Michael E. Grigg, Luiz Vicente Rizzo, Alessandra Gonçalves Commodaro
Publikováno v:
Emerging Infectious Diseases, Vol 22, Iss 4, Pp 691-693 (2016)
Emerging Infectious Diseases
Emerging Infectious Diseases
We found significantly higher incidence of Toxoplasma gondii DNA in eye bank specimens from Joinville in southern Brazil (13/15, 87%) than in São Paulo (3/42, 7%; p = 2.1 × 10E–8). PCR DNA sequence analysis was more sensitive at locus NTS2 than a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6be0716fb944c20852c739354a88901
https://wwwnc.cdc.gov/eid/article/22/4/14-1819_article
https://wwwnc.cdc.gov/eid/article/22/4/14-1819_article