Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Melissa A, Kacena"'
Autor:
Xiaomeng You, Jing Yan, Jeremy Herzog, Sabah Nobakhti, Ross Campbell, Allison Hoke, Rasha Hammamieh, R. Balfour Sartor, Sandra Shefelbine, Melissa A. Kacena, Nabarun Chakraborty, Julia F. Charles
Publikováno v:
Bone Research, Vol 12, Iss 1, Pp 1-14 (2024)
Abstract Emerging evidence suggests a significant role of gut microbiome in bone health. Aging is well recognized as a crucial factor influencing the gut microbiome. In this study, we investigated whether age-dependent microbial change contributes to
Externí odkaz:
https://doaj.org/article/be8bf58ec22c441a82a836a8bd5fb3a1
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/350badc3d5c84c1d930835c001b29b99
Autor:
Kexin Li, Xun Sun, Hudie Li, Hailan Ma, Meng Zhou, Kazumasa Minami, Keisuke Tamari, Kazuhiko Ogawa, Pankita H. Pandya, M. Reza Saadatzadeh, Melissa A. Kacena, Karen E. Pollok, Bai-Yan Li, Hiroki Yokota
Publikováno v:
Genes and Diseases, Vol 10, Iss 4, Pp 1641-1656 (2023)
Cancer cells tend to develop resistance to chemotherapy and enhance aggressiveness. A counterintuitive approach is to tame aggressiveness by an agent that acts opposite to chemotherapeutic agents. Based on this strategy, induced tumor-suppressing cel
Externí odkaz:
https://doaj.org/article/d040b7e31d9e44aebea1c63c1d145289
Autor:
Kexin Li, Qingji Huo, Nathan H Dimmitt, Guofan Qu, Junjie Bao, Pankita H Pandya, M Reza Saadatzadeh, Khadijeh Bijangi-Vishehsaraei, Melissa A Kacena, Karen E Pollok, Chien-Chi Lin, Bai-Yan Li, Hiroki Yokota
Publikováno v:
eLife, Vol 12 (2023)
Osteosarcoma (OS) is the common primary bone cancer that affects mostly children and young adults. To augment the standard-of-care chemotherapy, we examined the possibility of protein-based therapy using mesenchymal stem cells (MSCs)-derived proteome
Externí odkaz:
https://doaj.org/article/ba8234a336c14e4ea67c0a581db5fd95
Autor:
Vincent J. Alentado, Adam M. Knox, Caio A. Staut, Anthony C. McGuire, Joseph R. Chitwood, Sarah L. Mostardo, Mustufa Z. Shaikh, Rachel J. Blosser, Usashi C. Dadwal, Tien-Min Gabriel Chu, Christopher D. Collier, Jiliang Li, Ziyue Liu, Melissa A. Kacena, Roman M. Natoli
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Bony union is a primary predictor of outcome after surgical fixation of long bone fractures. Murine models offer many advantages in assessing bony healing due to their low costs and small size. However, current fracture recovery investigations in mic
Externí odkaz:
https://doaj.org/article/6ce389d46cbb45b9823756c245761eff
Autor:
Maysa S. Campos, José B. Volpon, João Paulo B. Ximenez, Ana Paula Franttini, Christopher E. Dalloul, Manoel D. Sousa-Neto, Raquel A. Silva, Melissa A. Kacena, Ariane Zamarioli
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
ObjectiveTo investigate the effects of vibration therapy on fracture healing in diabetic and non-diabetic rats.Methods148 rats underwent fracture surgery and were assigned to four groups: (1) SHAM: weight-matched non-diabetic rats, (2) SHAM+VT: non-d
Externí odkaz:
https://doaj.org/article/0b7d9155cd3546a297b2930af17d4900
Autor:
Ariane Zamarioli, Gremah Adam, Kevin A. Maupin, Paul J. Childress, Alexander Brinker, Joao P. B. Ximenez, Nabarun Chakraborty, Aarti Gautam, Rasha Hammamieh, Melissa A. Kacena
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Unloading associated with spaceflight results in bone loss and increased fracture risk. Bone morphogenetic protein 2 (BMP2) is known to enhance bone formation, in part, through molecular pathways associated with mechanical loading; however, the effec
Externí odkaz:
https://doaj.org/article/4e59d86ee2004f27a104adcdafd28f91
Autor:
Mariana Moraes de Lima Perini, Conner R. Valuch, Ushashi C. Dadwal, Olatundun D. Awosanya, Sarah L. Mostardo, Rachel J. Blosser, Adam M. Knox, Anthony C. McGuire, Hanisha L. Battina, Murad Nazzal, Melissa A. Kacena, Jiliang Li
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Angiogenesis is important for successful fracture repair. Aging negatively affects the number and activity of endothelial cells (ECs) and subsequently leads to impaired bone healing. We previously showed that implantation of lung-derived endothelial
Externí odkaz:
https://doaj.org/article/63033ed85c8b41a6823fdccf2985d33c
Autor:
Ariane Zamarioli, Zachery R. Campbell, Kevin A. Maupin, Paul J. Childress, Joao P. B. Ximenez, Gremah Adam, Nabarun Chakraborty, Aarti Gautam, Rasha Hammamieh, Melissa A. Kacena
Publikováno v:
npj Microgravity, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract With increased human presence in space, bone loss and fractures will occur. Thrombopoietin (TPO) is a recently patented bone healing agent. Here, we investigated the systemic effects of TPO on mice subjected to spaceflight and sustaining a b
Externí odkaz:
https://doaj.org/article/b975b97ec90645fda468f236688c4df4
Autor:
Nabarun Chakraborty, Ariane Zamarioli, Aarti Gautam, Ross Campbell, Stephen K Mendenhall, Paul J. Childress, George Dimitrov, Bintu Sowe, Aamir Tucker, Liming Zhao, Rasha Hammamieh, Melissa A. Kacena
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3507-3520 (2021)
Adverse effects of spaceflight on musculoskeletal health increase the risk of bone injury and impairment of fracture healing. Its yet elusive molecular comprehension warrants immediate attention, since space travel is becoming more frequent. Here we
Externí odkaz:
https://doaj.org/article/bfbb020e14e24e96ac4810d192aa352a