Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Melissa A, Calton"'
Autor:
Tereza Moore, Rolando E Yanes, Melissa A Calton, Douglas Vollrath, Gregory M Enns, Tina M Cowan
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240517 (2020)
Mitochondrial diseases are a clinically heterogenous group of disorders caused by respiratory chain dysfunction and associated with progressive, multi-systemic phenotype. There is no effective treatment or cure, and no FDA-approved drug for treating
Externí odkaz:
https://doaj.org/article/743c8b3b1cd748f48faba2d1f592c372
Autor:
Douglas Vollrath, Douglas Yasumura, Gillie Benchorin, Michael T Matthes, Wei Feng, Natalie M Nguyen, Cecilia D Sedano, Melissa A Calton, Matthew M LaVail
Publikováno v:
PLoS Genetics, Vol 11, Iss 12, p e1005723 (2015)
Inherited photoreceptor degenerations (IPDs) are the most genetically heterogeneous of Mendelian diseases. Many IPDs exhibit substantial phenotypic variability, but the basis is usually unknown. Mutations in MERTK cause recessive IPD phenotypes assoc
Externí odkaz:
https://doaj.org/article/19a3a470e84d47019d54bf619c2aa96c
Autor:
Jason Miller, Qitao Zhang, Sally Temple, Debra A. Thompson, Douglas Vollrath, Feriel Presswalla, David N. Zacks, Jeffrey H. Stern, Carol Charniga, Robin R. Ali, Melissa A. Calton
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose The accumulation of undigestible autofluorescent material (UAM), termed lipofuscin in vivo, is a hallmark of aged RPE. Lipofuscin derives, in part, from the incomplete degradation of phagocytized photoreceptor outer segments (OS). Whether thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580ff5f67e7af3631f487eee9062d295
http://europepmc.org/articles/PMC6692057
http://europepmc.org/articles/PMC6692057
Autor:
Melissa A Calton, Dasom Lee, Srividya Sundaresan, Diana Mendus, Rose Leu, Felix Wangsawihardja, Kenneth R Johnson, Mirna Mustapha
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e94549 (2014)
Early cochlear development is marked by an exuberant outgrowth of neurites that innervate multiple targets. The establishment of mature cochlear neural circuits is, however, dependent on the pruning of inappropriate axons and synaptic connections. Su
Externí odkaz:
https://doaj.org/article/f56dd616e6354a47b15481614e9782d9
Autor:
Daniel S Evans, Melissa A Calton, Mee J Kim, Pui-Yan Kwok, Iva Miljkovic, Tamara Harris, Annemarie Koster, Yongmei Liu, Gregory J Tranah, Nadav Ahituv, Wen-Chi Hsueh, Christian Vaisse
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96805 (2014)
Common genetic variants 3' of MC4R within two large linkage disequilibrium (LD) blocks spanning 288 kb have been associated with common and rare forms of obesity. This large association region has not been refined and the relevant DNA segments within
Externí odkaz:
https://doaj.org/article/b4ff536cb28a467589273e32108d6217
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
We investigated the effects of treating differentiated retinal pigment epithelial (RPE) cells with didanosine (ddI), which is associated with retinopathy in individuals with HIV/AIDS. We hypothesized that such treatment would cause depletion of mitoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b686a4a3a98e0a2867d52837ab370a
http://europepmc.org/articles/PMC6814719
http://europepmc.org/articles/PMC6814719
Autor:
Ming Chen, Stephen B. Montgomery, Dean Bok, Xin Li, Douglas Vollrath, Melissa A. Calton, Michael J. Gloudemans, Boxiang Liu, Brunilda Balliu, Nathan S. Abell, Gillie Benchorin, Jane Hu
The eye is an intricate organ with limited representation in large-scale functional genomics datasets. The retinal pigment epithelium (RPE) serves vital roles in ocular development and retinal homeostasis. We interrogated the genetics of gene express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fba4d5eb91a12948d750276f971b7b9
https://doi.org/10.1101/446799
https://doi.org/10.1101/446799
Autor:
Ming Chen, Stephen B. Montgomery, Nathan S. Abell, Xin Li, Gillie Benchorin, Douglas Vollrath, Dean Bok, Jane Hu, Brunilda Balliu, Boxiang Liu, Melissa A. Calton, Michael J. Gloudemans
Publikováno v:
Communications Biology
Communications Biology, Vol 2, Iss 1, Pp 1-13 (2019)
Communications Biology, Vol 2, Iss 1, Pp 1-13 (2019)
The retinal pigment epithelium (RPE) serves vital roles in ocular development and retinal homeostasis but has limited representation in large-scale functional genomics datasets. Understanding how common human genetic variants affect RPE gene expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f122c519272cd6866a406f3c43350b1
https://pubmed.ncbi.nlm.nih.gov/31123710
https://pubmed.ncbi.nlm.nih.gov/31123710
Publikováno v:
Molecular Vision
Purpose The Seahorse XFp platform is widely used for metabolic assessment of cultured cells. Current methods require replating of cells into specialized plates. This is problematic for certain cell types, such as primary human fetal RPE (hfRPE) cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22ae3a805e451c5a3c00643b29f91722
https://pubmed.ncbi.nlm.nih.gov/30034209
https://pubmed.ncbi.nlm.nih.gov/30034209
Publikováno v:
BIO-PROTOCOL. 7
The electroretinogram (ERG) is a sensitive and noninvasive method for testing retinal function. In this protocol, we describe a method for performing ERGs in mice. Contact lenses on the mouse cornea measure the electrical response to a light stimulus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe2240943bba96782670638048998e8a
https://doi.org/10.21769/bioprotoc.2218
https://doi.org/10.21769/bioprotoc.2218