Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Melissa Pink"'
Autor:
Jonathan D. Finn, Amy Rhoden Smith, Mihir C. Patel, Lucinda Shaw, Madeleine R. Youniss, Jane van Heteren, Tanner Dirstine, Corey Ciullo, Reynald Lescarbeau, Jessica Seitzer, Ruchi R. Shah, Aalok Shah, Dandan Ling, Jacqueline Growe, Melissa Pink, Ellen Rohde, Kristy M. Wood, William E. Salomon, William F. Harrington, Christian Dombrowski, Walter R. Strapps, Yong Chang, David V. Morrissey
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2227-2235 (2018)
Summary: The development of clinically viable delivery methods presents one of the greatest challenges in the therapeutic application of CRISPR/Cas9 mediated genome editing. Here, we report the development of a lipid nanoparticle (LNP)-mediated deliv
Externí odkaz:
https://doaj.org/article/f557a3a18840449b89062013d6e1f3ec
Autor:
Kerrie Faia, Kerry White, Erin Murphy, Jennifer Proctor, Melissa Pink, Nicole Kosmider, Karen McGovern, Jeffery Kutok
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0200725 (2018)
Duvelisib is an orally active dual inhibitor of PI3K-δ and PI3K-γ in clinical development in hematologic malignancies (HM). To identify novel pairings for duvelisib in HM, it was evaluated alone and in combination with 35 compounds comprising a div
Externí odkaz:
https://doaj.org/article/17386ff24025483b9da7dd2ce0f13701
Autor:
Wood Kristy M, Corey Ciullo, William Salomon, Finn Jonathan Douglas, Amy Madison Rhoden Smith, Jacqueline Growe, Dandan Ling, Reynald Lescarbeau, Youniss Madeleine, David V. Morrissey, Jessica Seitzer, Ellen Rohde, Tanner Dirstine, Ruchi Rudraprasad Shah, Lucinda Shaw, Melissa Pink, Mihir Patel, Christian Dombrowski, Chang Yong, Jane van Heteren, Aalok Shah, William F. Harrington, Walter Strapps
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2227-2235 (2018)
Summary: The development of clinically viable delivery methods presents one of the greatest challenges in the therapeutic application of CRISPR/Cas9 mediated genome editing. Here, we report the development of a lipid nanoparticle (LNP)-mediated deliv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0719aa81c3c1549aa7f9d9969ec3d6
http://www.sciencedirect.com/science/article/pii/S2211124718301827
http://www.sciencedirect.com/science/article/pii/S2211124718301827
Autor:
Melissa Pink, Mark V. Abrahams
Publikováno v:
Environmental Biology of Fishes. 101:355-362
Shallow freshwater aquatic ecosystems are discrete feeding patches for fish eating birds. A unique feature of these ecosystems is that their physical conditions can change dramatically in a short period of time, particularly temperature, turbidity, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c80722c9083c34c7ec906f32c551baa
https://doi.org/10.1007/s10641-017-0644-8
https://doi.org/10.1007/s10641-017-0644-8
Autor:
Christian M. Martin, Jennifer Proctor, Patrick O'Hearn, Janid A. Ali, Andre Lescarbeau, Jennifer Hoyt, Jonathan P. DiNitto, Ann M. Rowley, Thomas T. Tibbitts, Catherine A. Evans, Martin R. Tremblay, Tao Liu, Vito J. Palombella, John Soglia, Johan A. Pradeilles, Somarajan J. Nair, Melissa Pink, David G. Winkler, Stanley Goldstein, Quentin Glenadel, Erin L. O’Hearn, Culver Cheung, Erin Brophy, Alfredo C. Castro, Louis Grenier
Publikováno v:
ACS Medicinal Chemistry Letters. 7:862-867
Optimization of isoquinolinone PI3K inhibitors led to the discovery of a potent inhibitor of PI3K-γ (26 or IPI-549) with >100-fold selectivity over other lipid and protein kinases. IPI-549 demonstrates favorable pharmacokinetic properties and robust
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f2e63c8dbb32a50d02e0a4d22c2564
https://doi.org/10.1021/acsmedchemlett.6b00238
https://doi.org/10.1021/acsmedchemlett.6b00238
Autor:
Mark V. Abrahams, Melissa Pink
Publikováno v:
Canadian Journal of Fisheries and Aquatic Sciences. 73:869-876
Metabolic rates of fish and their activity levels have thermal optima. When environmental temperatures are below these optima, increasing temperature will increase their rates of energy consumption, resulting in a corresponding increase in the risk o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c96af087eb08cbb1cd691eb194f6fec
https://doi.org/10.1139/cjfas-2015-0302
https://doi.org/10.1139/cjfas-2015-0302
Autor:
Alice R. Lim, Pingda Ren, Yi Liu, Jonathan P. DiNitto, Christian C. Fritz, Katti Jessen, Erin Murphy, Vito J. Palombella, Jennifer Lussier, Janid A. Ali, Brian D. Thomas, Kerry White, Lian-Sheng Li, Paul S. Changelian, Melissa Pink, Joi Dunbar, Jennifer Hoyt, Erin Brophy, Bonnie Tillotson, James R. Porter, John Macdougall, David G. Winkler, Christian Rommel, Kerrie Faia, Christian M. Martin, Jennifer L. Proctor, Jeffery L. Kutok
Publikováno v:
Chemistry & Biology. 20:1364-1374
SummaryPhosphoinositide-3 kinase (PI3K)-δ and PI3K-γ are preferentially expressed in immune cells, and inhibitors targeting these isoforms are hypothesized to have anti-inflammatory activity by affecting the adaptive and innate immune response. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5813545be8573cae8ff4e65a9ba3e19c
https://doi.org/10.1016/j.chembiol.2013.09.017
https://doi.org/10.1016/j.chembiol.2013.09.017
Autor:
Luis Felipe Campesato, Sujata Sharma, Thomas T. Tibbitts, John Soglia, Vito J. Palombella, Arnab Ghosh, Daniel Hirschhorn Cymerman, Howard M. Stern, Julian Adams, Sadna Budhu, Taha Merghoub, Jedd D. Wolchok, Olivier De Henau, David W. Winkler, Mark Douglas, Matthew Rausch, Jennifer Proctor, Jeffery L. Kutok, Melissa Pink, Cailian Liu, Kerry White, Jeremy Tchaicha, Karen McGovern, Nicole Kosmider
Targeting tumour-infiltrating suppressive myeloid cells with a selective PI3Kγ inhibitor overcomes resistance to checkpoint blockade therapy in various mouse myeloid-rich tumour models. Therapeutic blockade of immune checkpoints with antibodies agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146586ff39d92fb2f745d0cf5ff48518
https://europepmc.org/articles/PMC5634331/
https://europepmc.org/articles/PMC5634331/
Autor:
Karen McGovern, Xuefeng Wu, Roman Sasik, Ezra E.W. Cohen, Matthew Rausch, Christopher J. Leem, Megan M. Kaneda, Kelly A. Frazer, Jeffery L. Kutok, David G. Winkler, Natacha Ralainirina, Michael C. Schmid, Melissa Pink, Gyunghwi Woo, Philippe Foubert, Judith A. Varner, Camila C. Figueiredo, Vito J. Palombella, Karen Messer, Abraham V. Nguyen, Hongying Li, Sara Gorjestani, Michael Karin
Publikováno v:
Nature, vol 539, iss 7629
Nature
Nature
Macrophages play critical, but opposite, roles in acute and chronic inflammation and cancer1,2,3,4,5. In response to pathogens or injury, inflammatory macrophages express cytokines that stimulate cytotoxic T cells, whereas macrophages in neoplastic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5e5772a792135f5bd0a151d9ee42c5
https://pubmed.ncbi.nlm.nih.gov/27974794
https://pubmed.ncbi.nlm.nih.gov/27974794
Autor:
Kerry White, Melissa Pink, Nicole Kosmider, Kerrie Faia, Karen McGovern, Jennifer L. Proctor, Jeffery L. Kutok, Erin Murphy
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 8, p e0200725 (2018)
PLoS ONE, Vol 13, Iss 8, p e0200725 (2018)
Duvelisib is an orally active dual inhibitor of PI3K-δ and PI3K-γ in clinical development in hematologic malignancies (HM). To identify novel pairings for duvelisib in HM, it was evaluated alone and in combination with 35 compounds comprising a div
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ed8efb06cb5f06a728aa2dd9bb3555
https://doi.org/10.1371/journal.pone.0200725
https://doi.org/10.1371/journal.pone.0200725