Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Melissa, Wagenaar"'
Autor:
Michael Paul Burns, Rajesh Kumar, Loren M. Price, Dorff Peter H, Robert John Maguire, Jeffrey T. Kohrt, Melissa Wagenaar, Manjinder S. Lall, Chewah Lee, Steven Victor O'neil
Publikováno v:
Organic Process Research & Development. 26:616-623
Spirocyclic ring systems are useful intermediates in the design and synthesis of medicinally active agents and commonly found as cores in natural products. Recently, syntheses of a key intermediate...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9a430403bd70bda39d90ef4cfa1f7a2
https://doi.org/10.1021/acs.oprd.1c00075
https://doi.org/10.1021/acs.oprd.1c00075
Autor:
Dennis Hyek, Jinshan Chen, R. Scott Obach, Melissa Wagenaar, Mark W. Bundesmann, Asser Bassyouni, Jeremy T. Starr, Maria S. Brown, Stephen Jenkinson, Manjinder S. Lall, Gregory Ciszewski, James Bradow, Gregory S. Walker, Senliang Pan, Douglas K. Spracklin, Bo Liu, Neal W. Sach, Daniel J Smaltz, Anne E. Hagen, Usa Reilly
Publikováno v:
Journal of Medicinal Chemistry. 63:7268-7292
An experimental approach is described for late-stage lead diversification of frontrunner drug candidates using nanomole-scale amounts of lead compounds for structure-activity relationship development. The process utilizes C-H bond activation methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a4f2cd830cd5ca3994e400969ad8fd2
https://doi.org/10.1021/acs.jmedchem.0c00483
https://doi.org/10.1021/acs.jmedchem.0c00483
Autor:
Manjinder S, Lall, Asser, Bassyouni, James, Bradow, Maria, Brown, Mark, Bundesmann, Jinshan, Chen, Gregory, Ciszewski, Anne E, Hagen, Dennis, Hyek, Stephen, Jenkinson, Bo, Liu, R Scott, Obach, Senliang, Pan, Usa, Reilly, Neal, Sach, Daniel J, Smaltz, Douglas K, Spracklin, Jeremy, Starr, Melissa, Wagenaar, Gregory S, Walker
Publikováno v:
Journal of medicinal chemistry. 63(13)
An experimental approach is described for late-stage lead diversification of frontrunner drug candidates using nanomole-scale amounts of lead compounds for structure-activity relationship development. The process utilizes C-H bond activation methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::64847a20d7e927f5644c919f79db1de5
https://pubmed.ncbi.nlm.nih.gov/32462865
https://pubmed.ncbi.nlm.nih.gov/32462865
Autor:
Edmund I. Graziani, Judy Lucas, L. Nathan Tumey, Frank Loganzo, Li-Ping Chang, Vlad Buklan, T. Eric Ballard, Fengping Li, Brian Rago, Christopher J. O’Donnell, Frank E. Koehn, Christine Hosselet, Jeffrey E. Janso, Anokha S. Ratnayake, Joseph A. Chemler, Xidong Feng, WeiDong Ding, Melissa Wagenaar, Sylvia Musto, Greg L. Steele
Publikováno v:
Bioconjugate chemistry. 30(1)
A potent class of DNA-damaging agents, natural product bis-intercalator depsipeptides (NPBIDs), was evaluated as ultrapotent payloads for use in antibody-drug conjugates (ADCs). Detailed investigation of potency (both in cells and via biophysical cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b8630b2cb7e375bc280f4c7a2ec5cb
https://pubmed.ncbi.nlm.nih.gov/30543418
https://pubmed.ncbi.nlm.nih.gov/30543418
Autor:
My-Hanh Lam, Christopher J. O’Donnell, Andreas Maderna, Sylvia Musto, Sai Chetan K. Sukuru, Zecheng Chen, Frank Loganzo, Melissa Wagenaar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6688-6694
In this Letter we describe the synthesis and biological evaluation of new benzosuberene analogs with structural modifications on the B-ring. The focus was initially to probe the chemical space around the B-ring C-8 position. This position was readily
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37635546e7e939fd6f4948610e43c806
https://doi.org/10.1016/j.bmcl.2013.10.039
https://doi.org/10.1016/j.bmcl.2013.10.039
Autor:
T. Mark Zabriskie, Brad Haltli, Nathan A. Magarvey, Melissa Wagenaar, Xihou Yin, John A. Hucul, Ying Tan, Michael Greenstein
Publikováno v:
Chemistry & Biology. 12(11):1163-1168
The mannopeptimycins (MPPs) are potent glycopeptide antibiotics that contain both D and L forms of the unique, arginine-derived amino acid beta-hydroxyenduracididine (betahEnd). The product of the mppO gene in the MPP biosynthetic cluster resembles s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8334bdaf01176a796abb4c97c9b05af4
Autor:
Chakrapani Subramanyam, Alison H. Varghese, Christopher J. O’Donnell, Michael J. Shapiro, Suman Shanker, Andreas Maderna, Cynthia Song, Beth C. Vetelino, My-Hanh Lam, Matthew David Doroski, Frank Loganzo, Hud Lawrence Risley, Kathleen A. Farley, Zecheng Chen, Melissa Wagenaar, Carolyn A. Leverett, Jayvardhan Pandit, Alexander M. Porte, Kevin D. Parris, Sylvia Musto, Sai Chetan K. Sukuru
Publikováno v:
Journal of medicinal chemistry. 57(24)
Auristatins, synthetic analogues of the antineoplastic natural product Dolastatin 10, are ultrapotent cytotoxic microtubule inhibitors that are clinically used as payloads in antibody-drug conjugates (ADCs). The design and synthesis of several new au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02da5b4b0c1a923d6ea1fa2b8f91094e
https://pubmed.ncbi.nlm.nih.gov/25431858
https://pubmed.ncbi.nlm.nih.gov/25431858