Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Melissa, Pille"'
1
Akademický článek
Gene editing-based targeted integration for correction of Wiskott-Aldrich syndrome
Autor: Melissa Pille, John M. Avila, So Hyun Park, Cuong Q. Le, Haipeng Xue, Filomeen Haerynck, Lavanya Saxena, Ciaran Lee, Elizabeth J. Shpall, Gang Bao, Bart Vandekerckhove, Brian R. Davis
Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101208- (2024)
Wiskott-Aldrich syndrome (WAS) is a severe X-linked primary immunodeficiency resulting from a diversity of mutations distributed across all 12 exons of the WAS gene. WAS encodes a hematopoietic-specific and developmentally regulated cytoplasmic prote
Externí odkaz: https://doaj.org/article/c869b7adf0164810aa0dd2b9dccebba3
Zobrazit plný text záznamu
2
Akademický článek
The Wiskott–Aldrich syndrome protein is required for positive selection during T-cell lineage differentiation
Autor: Melissa Pille, John Avila, Guillem Sanchez Sanchez, Glenn Goetgeluk, Stijn De Munter, Hanne Jansen, Lore Billiet, Karin Weening, Haipeng Xue, Sarah Bonte, Joline Ingels, Laurenz De Cock, Eva Pascal, Lucas Deseins, Tessa Kerre, Tom Taghon, Georges Leclercq, David Vermijlen, Brian Davis, Bart Vandekerckhove
Publikováno v: Frontiers in Immunology, Vol 14 (2023)
The Wiskott–Aldrich syndrome (WAS) is an X-linked primary immune deficiency caused by a mutation in the WAS gene. This leads to altered or absent WAS protein (WASp) expression and function resulting in thrombocytopenia, eczema, recurrent infections
Externí odkaz: https://doaj.org/article/8e328ea3407848819b605b95f452cf7f
Zobrazit plný text záznamu
3
Akademický článek
Cas9 RNP transfection by vapor nanobubble photoporation for ex vivo cell engineering
Autor: Laurens Raes, Melissa Pille, Aranit Harizaj, Glenn Goetgeluk, Jelter Van Hoeck, Stephan Stremersch, Juan C. Fraire, Toon Brans, Olivier Gerrit de Jong, Roel Maas-Bakker, Enrico Mastrobattista, Pieter Vader, Stefaan C. De Smedt, Bart Vandekerckhove, Koen Raemdonck, Kevin Braeckmans
Publikováno v: Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 696-707 (2021)
The CRISPR-Cas9 technology represents a powerful tool for genome engineering in eukaryotic cells, advancing both fundamental research and therapeutic strategies. Despite the enormous potential of the technology, efficient and direct intracellular del
Externí odkaz: https://doaj.org/article/d83a80530b204562bf8701e1aa7bfddd
Zobrazit plný text záznamu
4
Akademický článek
In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality
Autor: Sarah Bonte, Stijn de Munter, Lore Billiet, Glenn Goetgeluk, Joline Ingels, Hanne Jansen, Melissa Pille, Laurenz de Cock, Karin Weening, Tom Taghon, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre
Publikováno v: OncoImmunology, Vol 10, Iss 1 (2021)
T cell receptor (TCR)-redirected T cells target intracellular antigens such as Wilms’ tumor 1 (WT1), a tumor-associated antigen overexpressed in several malignancies, including acute myeloid leukemia (AML). For both chimeric antigen receptor (CAR)-
Externí odkaz: https://doaj.org/article/b8d37350b35e4c9e9ca7c2af1a96b344
Zobrazit plný text záznamu
5
Akademický článek
T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources
Autor: Sarah Bonte, Stijn De Munter, Glenn Goetgeluk, Joline Ingels, Melissa Pille, Lore Billiet, Tom Taghon, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre
Publikováno v: OncoImmunology, Vol 9, Iss 1 (2020)
Chimeric antigen receptor (CAR) T-cells have shown great promise in the treatment of B-cell malignancies. For acute myeloid leukemia (AML), however, the optimal target surface antigen has yet to be discovered. Alternatively, T-cell receptor (TCR)-red
Externí odkaz: https://doaj.org/article/8a9e6e8dd9154340bb2f53f8c0e0027b
Zobrazit plný text záznamu
8
Akademický článek
Human Thymic CD10+ PD-1+ Intraepithelial Lymphocyte Precursors Acquire Interleukin-15 Responsiveness at the CD1a– CD95+ CD28– CCR7– Developmental Stage
Autor: Lore Billiet, Glenn Goetgeluk, Sarah Bonte, Stijn De Munter, Laurenz De Cock, Melissa Pille, Joline Ingels, Hanne Jansen, Karin Weening, Filip Van Nieuwerburgh, Tessa Kerre, Tom Taghon, Georges Leclercq, Bart Vandekerckhove
Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 22, p 8785 (2020)
Human thymic CD8αα+ CD10+ PD-1+ αβ T cells selected through early agonist selection have been proposed as the putative thymic precursors of the human CD8αα+ intestinal intraepithelial lymphocytes (IELs). However, the progeny of these thymic pre
Externí odkaz: https://doaj.org/article/f15cf268ed5b4742a78571f56d5abebd
Zobrazit plný text záznamu
9
Akademický článek
Rapid and Effective Generation of Nanobody Based CARs using PCR and Gibson Assembly
Autor: Stijn De Munter, Alexander Van Parys, Layla Bral, Joline Ingels, Glenn Goetgeluk, Sarah Bonte, Melissa Pille, Lore Billiet, Karin Weening, Annick Verhee, Jose Van der Heyden, Tom Taghon, Georges Leclercq, Tessa Kerre, Jan Tavernier, Bart Vandekerckhove
Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 3, p 883 (2020)
Recent approval of chimeric antigen receptor (CAR) T cell therapy by the European Medicines Agency (EMA)/Federal and Drug Administration (FDA) and the remarkable results of CAR T clinical trials illustrate the curative potential of this therapy. Whil
Externí odkaz: https://doaj.org/article/83a54f189b9d4f34951f075863969ccb
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje